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Attenuated asymmetry of functional connectivity in schizophrenia: A high-resolution EEG study.

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Title: Attenuated asymmetry of functional connectivity in schizophrenia: A high-resolution EEG study.
Authors: Jalili, Mahdi (AUTHOR), Meuli, Reto (AUTHOR), Do, Kim Q. (AUTHOR), Hasler, Martin (AUTHOR), Crow, Timothy J. (AUTHOR), Knyazeva, Maria G. (AUTHOR)
Source: Psychophysiology. Jul2010, Vol. 47 Issue 4, p706-716. 11p. 1 Diagram, 3 Charts, 3 Graphs.
Subjects: Schizophrenia, Schizotypal personality disorder, Electroencephalography, Synchronization, Symmetry (Biology)
Abstract: The interhemispheric asymmetries that originate from connectivity-related structuring of the cortex are compromised in schizophrenia (SZ). Under the assumption that such abnormalities affect functional connectivity, we analyzed its correlate—EEG synchronization—in SZ patients and matched controls. We applied multivariate synchronization measures based on Laplacian EEG and tuned to various spatial scales. Compared to the controls who had rightward asymmetry at a local level (EEG power), rightward anterior and leftward posterior asymmetries at an intraregional level (1st and 2nd order S-estimator), and rightward global asymmetry (hemispheric S-estimator), SZ patients showed generally attenuated asymmetry, the effect being strongest for intraregional synchronization in the alpha and beta bands. The abnormalities of asymmetry increased with the duration of the disease and correlated with the negative symptoms. We discuss the tentative links between these findings and gross anatomical asymmetries, including the cerebral torque and gyrification pattern, in normal subjects and SZ patients. [ABSTRACT FROM AUTHOR]
Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Attenuated asymmetry of functional connectivity in schizophrenia: A high-resolution EEG study.
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  Data: <searchLink fieldCode="JN" term="%22Psychophysiology%22">Psychophysiology</searchLink>. Jul2010, Vol. 47 Issue 4, p706-716. 11p. 1 Diagram, 3 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Schizotypal+personality+disorder%22">Schizotypal personality disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Electroencephalography%22">Electroencephalography</searchLink><br /><searchLink fieldCode="DE" term="%22Synchronization%22">Synchronization</searchLink><br /><searchLink fieldCode="DE" term="%22Symmetry+%28Biology%29%22">Symmetry (Biology)</searchLink>
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  Data: The interhemispheric asymmetries that originate from connectivity-related structuring of the cortex are compromised in schizophrenia (SZ). Under the assumption that such abnormalities affect functional connectivity, we analyzed its correlate—EEG synchronization—in SZ patients and matched controls. We applied multivariate synchronization measures based on Laplacian EEG and tuned to various spatial scales. Compared to the controls who had rightward asymmetry at a local level (EEG power), rightward anterior and leftward posterior asymmetries at an intraregional level (1st and 2nd order S-estimator), and rightward global asymmetry (hemispheric S-estimator), SZ patients showed generally attenuated asymmetry, the effect being strongest for intraregional synchronization in the alpha and beta bands. The abnormalities of asymmetry increased with the duration of the disease and correlated with the negative symptoms. We discuss the tentative links between these findings and gross anatomical asymmetries, including the cerebral torque and gyrification pattern, in normal subjects and SZ patients. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychophysiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/j.1469-8986.2009.00971.x
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      – Code: eng
        Text: English
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              Text: Jul2010
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