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A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.

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Title: A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
Authors: SHEARER, JAMES (AUTHOR), SHANAHAN, MARIAN (AUTHOR), DARKE, SHANE (AUTHOR), RODGERS, CRAIG (AUTHOR), VAN BEEK, INGRID (AUTHOR), MCKETIN, REBECCA (AUTHOR), MATTICK, RICHARD P. (AUTHOR)
Source: Drug & Alcohol Review. May2010, Vol. 29 Issue 3, p235-242. 8p. 2 Diagrams, 5 Charts, 1 Graph.
Subjects: Methamphetamine, Cost effectiveness, Sensitivity analysis, Counseling, Drug abuse
Abstract: Introduction and Aims. To examine the cost-effectiveness of modafinil (200 mg daily) plus counselling compared with placebo for the treatment of psychostimulant dependence. Design and Methods. Cost and outcome data were collected alongside two randomised controlled trials of modafinil 200 mg daily over 10 weeks for methamphetamine (n = 74) and cocaine dependence (n = 8), respectively. Incremental cost-effectiveness ratios representing the additional costs to achieve a given outcome were calculated for both the change in the number of stimulant-free days and quality-adjusted life years 12 weeks post-treatment. Results. The incremental cost-effectiveness ratio indicated that it would cost an additional $AUD79 to achieve an extra stimulant-free day with modafinil compared with placebo. This result was not statistically significant, but appeared to be a robust estimate after sensitivity analysis. Counselling, whether received within program or from other services, improved the cost-effectiveness of modafinil relative to placebo. Discussion and Conclusions. Strategies to improve the uptake of counselling are recommended as cost-effective.[Shearer J, Shanahan M, Darke S, Rodgers C, van Beek I, McKetin R, Mattick RP. A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence. Drug Alcohol Rev 2010] [ABSTRACT FROM AUTHOR]
Copyright of Drug & Alcohol Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence.
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  Data: <searchLink fieldCode="AR" term="%22SHEARER%2C+JAMES%22">SHEARER, JAMES</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22SHANAHAN%2C+MARIAN%22">SHANAHAN, MARIAN</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22DARKE%2C+SHANE%22">DARKE, SHANE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22RODGERS%2C+CRAIG%22">RODGERS, CRAIG</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22VAN+BEEK%2C+INGRID%22">VAN BEEK, INGRID</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22MCKETIN%2C+REBECCA%22">MCKETIN, REBECCA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22MATTICK%2C+RICHARD+P%2E%22">MATTICK, RICHARD P.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Drug+%26+Alcohol+Review%22">Drug & Alcohol Review</searchLink>. May2010, Vol. 29 Issue 3, p235-242. 8p. 2 Diagrams, 5 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Methamphetamine%22">Methamphetamine</searchLink><br /><searchLink fieldCode="DE" term="%22Cost+effectiveness%22">Cost effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Sensitivity+analysis%22">Sensitivity analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Counseling%22">Counseling</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+abuse%22">Drug abuse</searchLink>
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  Data: Introduction and Aims. To examine the cost-effectiveness of modafinil (200 mg daily) plus counselling compared with placebo for the treatment of psychostimulant dependence. Design and Methods. Cost and outcome data were collected alongside two randomised controlled trials of modafinil 200 mg daily over 10 weeks for methamphetamine (n = 74) and cocaine dependence (n = 8), respectively. Incremental cost-effectiveness ratios representing the additional costs to achieve a given outcome were calculated for both the change in the number of stimulant-free days and quality-adjusted life years 12 weeks post-treatment. Results. The incremental cost-effectiveness ratio indicated that it would cost an additional $AUD79 to achieve an extra stimulant-free day with modafinil compared with placebo. This result was not statistically significant, but appeared to be a robust estimate after sensitivity analysis. Counselling, whether received within program or from other services, improved the cost-effectiveness of modafinil relative to placebo. Discussion and Conclusions. Strategies to improve the uptake of counselling are recommended as cost-effective.[Shearer J, Shanahan M, Darke S, Rodgers C, van Beek I, McKetin R, Mattick RP. A cost-effectiveness analysis of modafinil therapy for psychostimulant dependence. Drug Alcohol Rev 2010] [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Drug & Alcohol Review is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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