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Two cases of HLA-DR2-negative hypersomnia manifesting sleep-onset rapid eye movement periods in the multiple sleep latency test.

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Title: Two cases of HLA-DR2-negative hypersomnia manifesting sleep-onset rapid eye movement periods in the multiple sleep latency test.
Authors: Yoshida, Yasushi (AUTHOR), Kuroda, Kenji (AUTHOR), Mandai, Masaharu (AUTHOR), Satani, Seiji (AUTHOR), Emura, Narutsugu (AUTHOR), Ueda, Satoshi (AUTHOR), Matsumura, Hitoshi (AUTHOR), Yoneda, Hiroshi (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Apr99, Vol. 53 Issue 2, p295-297. 3p.
Subjects: Drowsiness, Rapid eye movement sleep, Narcolepsy
Abstract: We encountered two cases expressing excessive daytime sleepiness (EDS) and manifesting two or more sleep-onset rapid eye movement (REM) periods in the multiple sleep latency test. Unbearable daytime sleepiness occurred abruptly, which usually led to short-lasting naps, after which the patients felt refreshed. The EDS was successfully reduced by treatment with methylphenidate. In spite of these features similar to narcolepsy, these cases of REM hypersomnia did not present cataplexy or other auxiliary symptoms of narcolepsy, and, furthermore, the class-II human leukocyte antigen DR2 appeared to be negative. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Two cases of HLA-DR2-negative hypersomnia manifesting sleep-onset rapid eye movement periods in the multiple sleep latency test.
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  Data: <searchLink fieldCode="AR" term="%22Yoshida%2C+Yasushi%22">Yoshida, Yasushi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuroda%2C+Kenji%22">Kuroda, Kenji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mandai%2C+Masaharu%22">Mandai, Masaharu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Satani%2C+Seiji%22">Satani, Seiji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Emura%2C+Narutsugu%22">Emura, Narutsugu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ueda%2C+Satoshi%22">Ueda, Satoshi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Matsumura%2C+Hitoshi%22">Matsumura, Hitoshi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yoneda%2C+Hiroshi%22">Yoneda, Hiroshi</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Apr99, Vol. 53 Issue 2, p295-297. 3p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Drowsiness%22">Drowsiness</searchLink><br /><searchLink fieldCode="DE" term="%22Rapid+eye+movement+sleep%22">Rapid eye movement sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Narcolepsy%22">Narcolepsy</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: We encountered two cases expressing excessive daytime sleepiness (EDS) and manifesting two or more sleep-onset rapid eye movement (REM) periods in the multiple sleep latency test. Unbearable daytime sleepiness occurred abruptly, which usually led to short-lasting naps, after which the patients felt refreshed. The EDS was successfully reduced by treatment with methylphenidate. In spite of these features similar to narcolepsy, these cases of REM hypersomnia did not present cataplexy or other auxiliary symptoms of narcolepsy, and, furthermore, the class-II human leukocyte antigen DR2 appeared to be negative. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1046/j.1440-1819.1999.00525.x
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      – Code: eng
        Text: English
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        Type: general
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      – SubjectFull: Narcolepsy
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              Text: Apr99
              Type: published
              Y: 1999
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