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An early improvement threshold to predict response and remission in first-episode schizophrenia.

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Title: An early improvement threshold to predict response and remission in first-episode schizophrenia.
Authors: Schennach-Wolff, R., Seemüller, F. H., Mayr, A., Maier, W., Klingberg, S., Heuser, I., Klosterkötter, J., Gastpar, M., Häfner, H., Sauer, H., Schneider, F., Gaebel, W., Jäger, M., Möller, H.-J., Riedel, M., Schennach-Wolff, Rebecca (AUTHOR), Seemüller, Florian Hannes (AUTHOR), Mayr, Andreas (AUTHOR), Maier, Wolfgang (AUTHOR), Klingberg, Stefan (AUTHOR)
Source: British Journal of Psychiatry. Jun2010, Vol. 196 Issue 6, p460-466. 7p. 2 Diagrams, 3 Charts, 4 Graphs.
Subjects: Schizophrenia, Syndromes, Etiology of diseases, Psychotherapy patients, Pathological psychology
Abstract: Background: Early improvement with treatment is thought to be important in patients with first-episode schizophrenia, yet a valid definition is still outstanding.Aims: To develop a valid definition of early improvement and test its predictive validity regarding response and remission.Method: We examined 188 in-patients with first-episode schizophrenia. Early improvement was defined as improvement in Positive and Negative Syndrome Scale (PANSS) total score at week 2, response as a 40% PANSS total score improvement at end-point, and remission according to consensus criteria.Results: Reasonable predictive validity of early improvement was found for a 46% PANSS total score improvement at week 2 and a 50% improvement for remission (area under the curve: response 0.707, remission 0.692). Estimated confidence intervals ranged from 26 to 62% PANSS reduction for response and remission.Conclusions: Patients with a first episode of schizophrenia should improve by at least 30% in PANSS total score at week 2 to achieve response and remission. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: An early improvement threshold to predict response and remission in first-episode schizophrenia.
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  Data: <searchLink fieldCode="AR" term="%22Schennach-Wolff%2C+R%2E%22">Schennach-Wolff, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Seemüller%2C+F%2E+H%2E%22">Seemüller, F. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Mayr%2C+A%2E%22">Mayr, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Maier%2C+W%2E%22">Maier, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Klingberg%2C+S%2E%22">Klingberg, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Heuser%2C+I%2E%22">Heuser, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Klosterkötter%2C+J%2E%22">Klosterkötter, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Gastpar%2C+M%2E%22">Gastpar, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Häfner%2C+H%2E%22">Häfner, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Sauer%2C+H%2E%22">Sauer, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Schneider%2C+F%2E%22">Schneider, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Gaebel%2C+W%2E%22">Gaebel, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Jäger%2C+M%2E%22">Jäger, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Möller%2C+H%2E-J%2E%22">Möller, H.-J.</searchLink><br /><searchLink fieldCode="AR" term="%22Riedel%2C+M%2E%22">Riedel, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Schennach-Wolff%2C+Rebecca%22">Schennach-Wolff, Rebecca</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seemüller%2C+Florian+Hannes%22">Seemüller, Florian Hannes</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mayr%2C+Andreas%22">Mayr, Andreas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maier%2C+Wolfgang%22">Maier, Wolfgang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Klingberg%2C+Stefan%22">Klingberg, Stefan</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Jun2010, Vol. 196 Issue 6, p460-466. 7p. 2 Diagrams, 3 Charts, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Syndromes%22">Syndromes</searchLink><br /><searchLink fieldCode="DE" term="%22Etiology+of+diseases%22">Etiology of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Psychotherapy+patients%22">Psychotherapy patients</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink>
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  Data: <bold>Background: </bold>Early improvement with treatment is thought to be important in patients with first-episode schizophrenia, yet a valid definition is still outstanding.<bold>Aims: </bold>To develop a valid definition of early improvement and test its predictive validity regarding response and remission.<bold>Method: </bold>We examined 188 in-patients with first-episode schizophrenia. Early improvement was defined as improvement in Positive and Negative Syndrome Scale (PANSS) total score at week 2, response as a 40% PANSS total score improvement at end-point, and remission according to consensus criteria.<bold>Results: </bold>Reasonable predictive validity of early improvement was found for a 46% PANSS total score improvement at week 2 and a 50% improvement for remission (area under the curve: response 0.707, remission 0.692). Estimated confidence intervals ranged from 26 to 62% PANSS reduction for response and remission.<bold>Conclusions: </bold>Patients with a first episode of schizophrenia should improve by at least 30% in PANSS total score at week 2 to achieve response and remission. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=51778366
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