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Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180.

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Title: Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180.
Authors: Stork, O. (AUTHOR), Welzl, H. (AUTHOR), Wolfer, D. (AUTHOR), Schuster, T. (AUTHOR), Mantei, N. (AUTHOR), Stork, S. (AUTHOR), Hoyer, D. (AUTHOR), Lipp, H. ‐P. (AUTHOR), Obata, K. (AUTHOR), Schachner, M. (AUTHOR)
Source: European Journal of Neuroscience. Sep2000, Vol. 12 Issue 9, p3291-3306. 16p. 1 Chart.
Subjects: Cell adhesion molecules, Neurons, Transgenic mice, Animal behavior, Nervous system
Abstract: AbstractIn the present study we further investigate functions of the neural cell adhesion molecule (NCAM) in the mature central nervous system and its implications for animal behaviour. To this end we generated transgenic mice expressing the major NCAM isoform with the largest cytoplasmic domain, NCAM180, under control of a promoter for the small form neurofilament gene. Transgenic mice were also bred with mice deficient in endogenous NCAM (Ncam–/– mice) so that effects of NCAM180 could be analysed in the presence and absence of endogenous NCAM. While overexpression of transgenic NCAM180 was without apparent behavioural or morphological effect, its expression in Ncam–/– mice counteracted NCAM ablation-induced aggressive, anxiety-like and antidepressant-like behaviour. It furthermore prevented a hypersensitivity of Ncam–/– mice to the anxiolytic serotonin1A (5-HT1A) receptor agonist buspirone. Such recovery of emotional behaviour and behavioural 5-HT1A response occurred in spite of misdevelopment of the olfactory bulb and hippocampus that is characteristic of Ncam–/– mice, and without an apparent change in the expression of 5-HT1A binding sites in the brain. Hippocampus- and amygdala-dependent learning, though disturbed in Ncam–/– mice, remained unaffected by the transgenic NCAM180. We suggest an involvement of NCAM180-mediated cell recognition processes in the serotonergic modulation of emotional behaviour in adult mice. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180.
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  Data: <searchLink fieldCode="AR" term="%22Stork%2C+O%2E%22">Stork, O.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Welzl%2C+H%2E%22">Welzl, H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wolfer%2C+D%2E%22">Wolfer, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schuster%2C+T%2E%22">Schuster, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mantei%2C+N%2E%22">Mantei, N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stork%2C+S%2E%22">Stork, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoyer%2C+D%2E%22">Hoyer, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lipp%2C+H%2E+‐P%2E%22">Lipp, H. ‐P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Obata%2C+K%2E%22">Obata, K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schachner%2C+M%2E%22">Schachner, M.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2000, Vol. 12 Issue 9, p3291-3306. 16p. 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Cell+adhesion+molecules%22">Cell adhesion molecules</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Transgenic+mice%22">Transgenic mice</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+behavior%22">Animal behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system%22">Nervous system</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: AbstractIn the present study we further investigate functions of the neural cell adhesion molecule (NCAM) in the mature central nervous system and its implications for animal behaviour. To this end we generated transgenic mice expressing the major NCAM isoform with the largest cytoplasmic domain, NCAM180, under control of a promoter for the small form neurofilament gene. Transgenic mice were also bred with mice deficient in endogenous NCAM (Ncam–/– mice) so that effects of NCAM180 could be analysed in the presence and absence of endogenous NCAM. While overexpression of transgenic NCAM180 was without apparent behavioural or morphological effect, its expression in Ncam–/– mice counteracted NCAM ablation-induced aggressive, anxiety-like and antidepressant-like behaviour. It furthermore prevented a hypersensitivity of Ncam–/– mice to the anxiolytic serotonin1A (5-HT1A) receptor agonist buspirone. Such recovery of emotional behaviour and behavioural 5-HT1A response occurred in spite of misdevelopment of the olfactory bulb and hippocampus that is characteristic of Ncam–/– mice, and without an apparent change in the expression of 5-HT1A binding sites in the brain. Hippocampus- and amygdala-dependent learning, though disturbed in Ncam–/– mice, remained unaffected by the transgenic NCAM180. We suggest an involvement of NCAM180-mediated cell recognition processes in the serotonergic modulation of emotional behaviour in adult mice. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1046/j.1460-9568.2000.00197.x
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      – TitleFull: Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180.
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              Text: Sep2000
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