Stimulus-function, wind-up and modulation by diffuse noxious inhibitory controls of responses of convergent neurons of the spinal trigeminal nucleus oralis.
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| Title: | Stimulus-function, wind-up and modulation by diffuse noxious inhibitory controls of responses of convergent neurons of the spinal trigeminal nucleus oralis. |
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| Authors: | Dallel, Radhouane (AUTHOR), Duale, Christian (AUTHOR), Luccarini, Philippe (AUTHOR), Molat, Jean‐Louis (AUTHOR) |
| Source: | European Journal of Neuroscience. Jan1999, Vol. 11 Issue 1, p31-40. 10p. |
| Subjects: | Trigeminal nerve, Neural physiology, Neurophysiology |
| Abstract: | Abstract Extracellular unitary recordings were made from 53 spinal trigeminal nucleus oralis (Sp5O) convergent neurons in halothane-anaesthetized rats. The neurons had an ipsilateral receptive field including mainly oral or perioral regions. They responded to percutaneous electrical stimulation with two peaks of activation. The first had a short latency (4.3 ± 0.3 ms) and low threshold (0.35 ± 0.04 mA), whereas the second had a longer latency (68.1 ± 3.4 ms) and higher threshold (7.3 ± 0.5 mA). Intracutaneous injection of capsaicin (0.1%) produced a strong and rapid reduction of the long-latency responses of Sp5O convergent neurons with little effect on the short-latency responses. In most cases (73%), the long-latency responses exhibited a wind-up phenomenon during repetitive (0.66 Hz) suprathreshold electrical stimulation. These results suggest that C-fibres mediate the long-latency response of Sp5O convergent neurons. Regarding the C-fibre-evoked responses, a linear relationship between the intensity of the applied current and the magnitude of the response was found within the one to three times threshold range. The Sp5O convergent neurons also encoded the intensity of mechanical stimuli applied to the skin or mucosa in the 5–50 g ranges. The evoked activity of Sp5O convergent neurons could be suppressed by noxious heat applied to the tail (52 °C) and long-lasting poststimulus effects followed this. These findings show that convergent neurons in the Sp5O resemble those in the deep laminae of the spinal dorsal horn and spinal trigeminal nucleus caudalis, and further support that the Sp5O plays a part in the processing of nociceptive information from the orofacial region. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 5185764 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Stimulus-function, wind-up and modulation by diffuse noxious inhibitory controls of responses of convergent neurons of the spinal trigeminal nucleus oralis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dallel%2C+Radhouane%22">Dallel, Radhouane</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duale%2C+Christian%22">Duale, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luccarini%2C+Philippe%22">Luccarini, Philippe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Molat%2C+Jean‐Louis%22">Molat, Jean‐Louis</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jan1999, Vol. 11 Issue 1, p31-40. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Trigeminal+nerve%22">Trigeminal nerve</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+physiology%22">Neural physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Neurophysiology%22">Neurophysiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract Extracellular unitary recordings were made from 53 spinal trigeminal nucleus oralis (Sp5O) convergent neurons in halothane-anaesthetized rats. The neurons had an ipsilateral receptive field including mainly oral or perioral regions. They responded to percutaneous electrical stimulation with two peaks of activation. The first had a short latency (4.3 ± 0.3 ms) and low threshold (0.35 ± 0.04 mA), whereas the second had a longer latency (68.1 ± 3.4 ms) and higher threshold (7.3 ± 0.5 mA). Intracutaneous injection of capsaicin (0.1%) produced a strong and rapid reduction of the long-latency responses of Sp5O convergent neurons with little effect on the short-latency responses. In most cases (73%), the long-latency responses exhibited a wind-up phenomenon during repetitive (0.66 Hz) suprathreshold electrical stimulation. These results suggest that C-fibres mediate the long-latency response of Sp5O convergent neurons. Regarding the C-fibre-evoked responses, a linear relationship between the intensity of the applied current and the magnitude of the response was found within the one to three times threshold range. The Sp5O convergent neurons also encoded the intensity of mechanical stimuli applied to the skin or mucosa in the 5–50 g ranges. The evoked activity of Sp5O convergent neurons could be suppressed by noxious heat applied to the tail (52 °C) and long-lasting poststimulus effects followed this. These findings show that convergent neurons in the Sp5O resemble those in the deep laminae of the spinal dorsal horn and spinal trigeminal nucleus caudalis, and further support that the Sp5O plays a part in the processing of nociceptive information from the orofacial region. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1046/j.1460-9568.1999.00404.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 31 Subjects: – SubjectFull: Trigeminal nerve Type: general – SubjectFull: Neural physiology Type: general – SubjectFull: Neurophysiology Type: general Titles: – TitleFull: Stimulus-function, wind-up and modulation by diffuse noxious inhibitory controls of responses of convergent neurons of the spinal trigeminal nucleus oralis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dallel, Radhouane – PersonEntity: Name: NameFull: Duale, Christian – PersonEntity: Name: NameFull: Luccarini, Philippe – PersonEntity: Name: NameFull: Molat, Jean‐Louis IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan1999 Type: published Y: 1999 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
