Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot study.
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| Title: | Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot study. |
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| Authors: | Termine, C., Trotti, R., Ondei, P., Gamba, G., Montani, N., Gamba, A., De Simone, M., Marni, E., Balottin, U. |
| Source: | Acta Neurologica Scandinavica. Aug2010, Vol. 122 Issue 2, p91-96. 6p. 2 Charts. |
| Subjects: | Mitral valve, Hemostatics, Migraine in children, Cluster headache, Blood coagulation factors, Glycoproteins, Echocardiography |
| Abstract: | Termine C, Trotti R, Ondei P, Gamba G, Montani N, Gamba A, De Simone M, Marni E, Balottin U. Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot study. Acta Neurol Scand: 2010: 122: 91–96. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objective – To investigate the prevalence of mitral valve prolapse (MVP) and abnormalities of haemostasis in children and adolescents with migraine with aura (MA) compared with peers affected by other idiopathic headaches. Materials and methods – We recruited 20 MA patients (10 men and 10 women; age range 8–17 years) and 20 sex- and age-matched subjects with other idiopathic headaches. Both groups underwent colour Doppler transthoracic echocardiography to detect MVP and the following laboratory work-up: plasma prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, protein C, protein S, homocysteine, lupus anticoagulant, von Willebrand factor (vWF) ristocetin cofactor activity, immunoglobulins (Ig) G and M anticardiolipin antibodies (aCL). Factor V Leiden, factor II and methylenetetrahydrofolate reductase were investigated (we did not test the entire genes, but screened for specific point mutations). Results – The prevalence of MVP was significantly higher in the MA subjects than in the patients affected by other idiopathic headaches (40% vs 10%; P < 0.05). Moreover, the MA patients showed a higher rate of above-normal IgM aCL titres (45% vs 10%; P < 0.05). Finally, in the group of patients with MVP we found a higher prevalence of aCL in those with MA compared with those affected by other idiopathic headaches. Conclusions – A proportion, at least, of the MA patients showed a more complex phenotype characterized by MVP and/or positive aCL titres. The pathogenetic role of these associations is obscure and larger studies are needed to confirm the usefulness of echocardiographic and laboratory investigations in this area and to identify possible new treatment approaches that might be explored in this group of MA patients. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 51985856 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Termine%2C+C%2E%22">Termine, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Trotti%2C+R%2E%22">Trotti, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Ondei%2C+P%2E%22">Ondei, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Gamba%2C+G%2E%22">Gamba, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Montani%2C+N%2E%22">Montani, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Gamba%2C+A%2E%22">Gamba, A.</searchLink><br /><searchLink fieldCode="AR" term="%22De+Simone%2C+M%2E%22">De Simone, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Marni%2C+E%2E%22">Marni, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Balottin%2C+U%2E%22">Balottin, U.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Aug2010, Vol. 122 Issue 2, p91-96. 6p. 2 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mitral+valve%22">Mitral valve</searchLink><br /><searchLink fieldCode="DE" term="%22Hemostatics%22">Hemostatics</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine+in+children%22">Migraine in children</searchLink><br /><searchLink fieldCode="DE" term="%22Cluster+headache%22">Cluster headache</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+coagulation+factors%22">Blood coagulation factors</searchLink><br /><searchLink fieldCode="DE" term="%22Glycoproteins%22">Glycoproteins</searchLink><br /><searchLink fieldCode="DE" term="%22Echocardiography%22">Echocardiography</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Termine C, Trotti R, Ondei P, Gamba G, Montani N, Gamba A, De Simone M, Marni E, Balottin U. Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot study. Acta Neurol Scand: 2010: 122: 91–96. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objective – To investigate the prevalence of mitral valve prolapse (MVP) and abnormalities of haemostasis in children and adolescents with migraine with aura (MA) compared with peers affected by other idiopathic headaches. Materials and methods – We recruited 20 MA patients (10 men and 10 women; age range 8–17 years) and 20 sex- and age-matched subjects with other idiopathic headaches. Both groups underwent colour Doppler transthoracic echocardiography to detect MVP and the following laboratory work-up: plasma prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen, protein C, protein S, homocysteine, lupus anticoagulant, von Willebrand factor (vWF) ristocetin cofactor activity, immunoglobulins (Ig) G and M anticardiolipin antibodies (aCL). Factor V Leiden, factor II and methylenetetrahydrofolate reductase were investigated (we did not test the entire genes, but screened for specific point mutations). Results – The prevalence of MVP was significantly higher in the MA subjects than in the patients affected by other idiopathic headaches (40% vs 10%; P < 0.05). Moreover, the MA patients showed a higher rate of above-normal IgM aCL titres (45% vs 10%; P < 0.05). Finally, in the group of patients with MVP we found a higher prevalence of aCL in those with MA compared with those affected by other idiopathic headaches. Conclusions – A proportion, at least, of the MA patients showed a more complex phenotype characterized by MVP and/or positive aCL titres. The pathogenetic role of these associations is obscure and larger studies are needed to confirm the usefulness of echocardiographic and laboratory investigations in this area and to identify possible new treatment approaches that might be explored in this group of MA patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1600-0404.2009.01268.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 91 Subjects: – SubjectFull: Mitral valve Type: general – SubjectFull: Hemostatics Type: general – SubjectFull: Migraine in children Type: general – SubjectFull: Cluster headache Type: general – SubjectFull: Blood coagulation factors Type: general – SubjectFull: Glycoproteins Type: general – SubjectFull: Echocardiography Type: general Titles: – TitleFull: Mitral valve prolapse and abnormalities of haemostasis in children and adolescents with migraine with aura and other idiopathic headaches: a pilot study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Termine, C. – PersonEntity: Name: NameFull: Trotti, R. – PersonEntity: Name: NameFull: Ondei, P. – PersonEntity: Name: NameFull: Gamba, G. – PersonEntity: Name: NameFull: Montani, N. – PersonEntity: Name: NameFull: Gamba, A. – PersonEntity: Name: NameFull: De Simone, M. – PersonEntity: Name: NameFull: Marni, E. – PersonEntity: Name: NameFull: Balottin, U. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 122 – Type: issue Value: 2 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
| ResultId | 1 |
