View in EDS PDF Full Text

Striatal microRNA controls cocaine intake through CREB signalling.

Saved in:
Bibliographic Details
Title: Striatal microRNA controls cocaine intake through CREB signalling.
Authors: Hollander, Jonathan A., Im, Heh-In, Amelio, Antonio L., Kocerha, Jannet, Bali, Purva, Qun Lu, Willoughby, David, Wahlestedt, Claes, Conkright, Michael D., Kenny, Paul J.
Source: Nature. 7/8/2010, Vol. 466 Issue 7303, p197-202. 6p. 6 Graphs.
Subjects: Cocaine abuse, Drug abuse, Cocaine, Laboratory rats, Treatment of drug addiction, Carrier proteins, Adenylate cyclase, Non-coding RNA, Therapeutics
Abstract: Cocaine addiction is characterized by a gradual loss of control over drug use, but the molecular mechanisms regulating vulnerability to this process remain unclear. Here we report that microRNA-212 (miR-212) is upregulated in the dorsal striatum of rats with a history of extended access to cocaine. Striatal miR-212 decreases responsiveness to the motivational properties of cocaine by markedly amplifying the stimulatory effects of the drug on cAMP response element binding protein (CREB) signalling. This action occurs through miR-212-enhanced Raf1 activity, resulting in adenylyl cyclase sensitization and increased expression of the essential CREB co-activator TORC (transducer of regulated CREB; also known as CRTC). Our findings indicate that striatal miR-212 signalling has a key role in determining vulnerability to cocaine addiction, reveal new molecular regulators that control the complex actions of cocaine in brain reward circuitries and provide an entirely new direction for the development of anti-addiction therapeutics based on the modulation of noncoding RNAs. [ABSTRACT FROM AUTHOR]
Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 51990260
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Striatal microRNA controls cocaine intake through CREB signalling.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Hollander%2C+Jonathan+A%2E%22">Hollander, Jonathan A.</searchLink><br /><searchLink fieldCode="AR" term="%22Im%2C+Heh-In%22">Im, Heh-In</searchLink><br /><searchLink fieldCode="AR" term="%22Amelio%2C+Antonio+L%2E%22">Amelio, Antonio L.</searchLink><br /><searchLink fieldCode="AR" term="%22Kocerha%2C+Jannet%22">Kocerha, Jannet</searchLink><br /><searchLink fieldCode="AR" term="%22Bali%2C+Purva%22">Bali, Purva</searchLink><br /><searchLink fieldCode="AR" term="%22Qun+Lu%22">Qun Lu</searchLink><br /><searchLink fieldCode="AR" term="%22Willoughby%2C+David%22">Willoughby, David</searchLink><br /><searchLink fieldCode="AR" term="%22Wahlestedt%2C+Claes%22">Wahlestedt, Claes</searchLink><br /><searchLink fieldCode="AR" term="%22Conkright%2C+Michael+D%2E%22">Conkright, Michael D.</searchLink><br /><searchLink fieldCode="AR" term="%22Kenny%2C+Paul+J%2E%22">Kenny, Paul J.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 7/8/2010, Vol. 466 Issue 7303, p197-202. 6p. 6 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cocaine+abuse%22">Cocaine abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+abuse%22">Drug abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Cocaine%22">Cocaine</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+drug+addiction%22">Treatment of drug addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Carrier+proteins%22">Carrier proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Adenylate+cyclase%22">Adenylate cyclase</searchLink><br /><searchLink fieldCode="DE" term="%22Non-coding+RNA%22">Non-coding RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cocaine addiction is characterized by a gradual loss of control over drug use, but the molecular mechanisms regulating vulnerability to this process remain unclear. Here we report that microRNA-212 (miR-212) is upregulated in the dorsal striatum of rats with a history of extended access to cocaine. Striatal miR-212 decreases responsiveness to the motivational properties of cocaine by markedly amplifying the stimulatory effects of the drug on cAMP response element binding protein (CREB) signalling. This action occurs through miR-212-enhanced Raf1 activity, resulting in adenylyl cyclase sensitization and increased expression of the essential CREB co-activator TORC (transducer of regulated CREB; also known as CRTC). Our findings indicate that striatal miR-212 signalling has a key role in determining vulnerability to cocaine addiction, reveal new molecular regulators that control the complex actions of cocaine in brain reward circuitries and provide an entirely new direction for the development of anti-addiction therapeutics based on the modulation of noncoding RNAs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=51990260
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/nature09202
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 197
    Subjects:
      – SubjectFull: Cocaine abuse
        Type: general
      – SubjectFull: Drug abuse
        Type: general
      – SubjectFull: Cocaine
        Type: general
      – SubjectFull: Laboratory rats
        Type: general
      – SubjectFull: Treatment of drug addiction
        Type: general
      – SubjectFull: Carrier proteins
        Type: general
      – SubjectFull: Adenylate cyclase
        Type: general
      – SubjectFull: Non-coding RNA
        Type: general
      – SubjectFull: Therapeutics
        Type: general
    Titles:
      – TitleFull: Striatal microRNA controls cocaine intake through CREB signalling.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hollander, Jonathan A.
      – PersonEntity:
          Name:
            NameFull: Im, Heh-In
      – PersonEntity:
          Name:
            NameFull: Amelio, Antonio L.
      – PersonEntity:
          Name:
            NameFull: Kocerha, Jannet
      – PersonEntity:
          Name:
            NameFull: Bali, Purva
      – PersonEntity:
          Name:
            NameFull: Qun Lu
      – PersonEntity:
          Name:
            NameFull: Willoughby, David
      – PersonEntity:
          Name:
            NameFull: Wahlestedt, Claes
      – PersonEntity:
          Name:
            NameFull: Conkright, Michael D.
      – PersonEntity:
          Name:
            NameFull: Kenny, Paul J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 08
              M: 07
              Text: 7/8/2010
              Type: published
              Y: 2010
          Identifiers:
            – Type: issn-print
              Value: 00280836
          Numbering:
            – Type: volume
              Value: 466
            – Type: issue
              Value: 7303
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1