CTP (Cochlin-tomoprotein) detection in the profuse fluid leakage (gusher) from cochleostomy.
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| Title: | CTP (Cochlin-tomoprotein) detection in the profuse fluid leakage (gusher) from cochleostomy. |
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| Authors: | Ikezono, Tetsuo (AUTHOR), Sugizaki, Kazuki (AUTHOR), Shindo, Susumu (AUTHOR), Sekiguchi, Satomi (AUTHOR), Pawankar, Ruby (AUTHOR), Baba, Shunkichi (AUTHOR), Yagi, Toshiaki (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Aug2010, Vol. 130 Issue 8, p881-887. 7p. 4 Black and White Photographs, 3 Charts. |
| Subjects: | Perilymph, Cerebrospinal fluid, Cochlear implants, Body fluid analysis, Body fluid pressure |
| Abstract: | Conclusions: By testing 125 samples, we confirmed that Cochlin-tomoprotein (CTP) is present in the perilymph, not in cerebrospinal fluid (CSF). Perilymph and CSF exist in two distinct compartments, even in the case of a malformed inner ear with a bony defect in the lamina cribrosa, as described here. Cochleostomy might have suddenly decreased the perilymph pressure, allowing the influx of CSF into the inner ear resulting in profuse fluid leakage, first perilymph then CSF. Objectives: The first purpose of this study was to further confirm the specificity of the perilymph-specific protein CTP that we reported recently. Secondly, we assessed the nature of the fluid leakage from the cochleostomy using the CTP detection test. Methods: A standardized CTP detection test was performed on 65 perilymph and 60 CSF samples. Samples of profuse fluid leakage collected from cochleostomy during cochlear implantation surgery of one patient with branchio-oto-renal (BOR) syndrome were also tested by the CTP detection test. Results: CTP was detected in 60 of 65 perilymph samples but not in any of the CSF samples. The leaked fluid was shown to contain CTP, i.e. perilymph, at the outset, and then the CTP detection signals gradually disappeared as time elapsed. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 52175125 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: CTP (Cochlin-tomoprotein) detection in the profuse fluid leakage (gusher) from cochleostomy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ikezono%2C+Tetsuo%22">Ikezono, Tetsuo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sugizaki%2C+Kazuki%22">Sugizaki, Kazuki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shindo%2C+Susumu%22">Shindo, Susumu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sekiguchi%2C+Satomi%22">Sekiguchi, Satomi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pawankar%2C+Ruby%22">Pawankar, Ruby</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baba%2C+Shunkichi%22">Baba, Shunkichi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yagi%2C+Toshiaki%22">Yagi, Toshiaki</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Aug2010, Vol. 130 Issue 8, p881-887. 7p. 4 Black and White Photographs, 3 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Perilymph%22">Perilymph</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebrospinal+fluid%22">Cerebrospinal fluid</searchLink><br /><searchLink fieldCode="DE" term="%22Cochlear+implants%22">Cochlear implants</searchLink><br /><searchLink fieldCode="DE" term="%22Body+fluid+analysis%22">Body fluid analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Body+fluid+pressure%22">Body fluid pressure</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Conclusions: By testing 125 samples, we confirmed that Cochlin-tomoprotein (CTP) is present in the perilymph, not in cerebrospinal fluid (CSF). Perilymph and CSF exist in two distinct compartments, even in the case of a malformed inner ear with a bony defect in the lamina cribrosa, as described here. Cochleostomy might have suddenly decreased the perilymph pressure, allowing the influx of CSF into the inner ear resulting in profuse fluid leakage, first perilymph then CSF. Objectives: The first purpose of this study was to further confirm the specificity of the perilymph-specific protein CTP that we reported recently. Secondly, we assessed the nature of the fluid leakage from the cochleostomy using the CTP detection test. Methods: A standardized CTP detection test was performed on 65 perilymph and 60 CSF samples. Samples of profuse fluid leakage collected from cochleostomy during cochlear implantation surgery of one patient with branchio-oto-renal (BOR) syndrome were also tested by the CTP detection test. Results: CTP was detected in 60 of 65 perilymph samples but not in any of the CSF samples. The leaked fluid was shown to contain CTP, i.e. perilymph, at the outset, and then the CTP detection signals gradually disappeared as time elapsed. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3109/00016480903508910 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 881 Subjects: – SubjectFull: Perilymph Type: general – SubjectFull: Cerebrospinal fluid Type: general – SubjectFull: Cochlear implants Type: general – SubjectFull: Body fluid analysis Type: general – SubjectFull: Body fluid pressure Type: general Titles: – TitleFull: CTP (Cochlin-tomoprotein) detection in the profuse fluid leakage (gusher) from cochleostomy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ikezono, Tetsuo – PersonEntity: Name: NameFull: Sugizaki, Kazuki – PersonEntity: Name: NameFull: Shindo, Susumu – PersonEntity: Name: NameFull: Sekiguchi, Satomi – PersonEntity: Name: NameFull: Pawankar, Ruby – PersonEntity: Name: NameFull: Baba, Shunkichi – PersonEntity: Name: NameFull: Yagi, Toshiaki IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 00016489 Numbering: – Type: volume Value: 130 – Type: issue Value: 8 Titles: – TitleFull: Acta Oto-Laryngologica Type: main |
| ResultId | 1 |
