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SPECT in Alzheimer's disease:features associated with bilateral parietotemporal hypoperfusion.

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Title: SPECT in Alzheimer's disease:features associated with bilateral parietotemporal hypoperfusion.
Authors: Nitrini, R., Buchpiguel, C. A., Caramelli, P., Bahia, V. S., Mathias, S. C., Nascimento, C. M. R., Degenszajn, J., Caixeta, L.
Source: Acta Neurologica Scandinavica. Mar2000, Vol. 101 Issue 3, p172-176. 5p. 2 Charts.
Subjects: Cerebral circulation, Alzheimer's disease
Abstract: Abstract Objective – To investigate why bilateral parietotemporal hypoperfusion, the typical SPECT pattern of Alzheimer's disease (AD), occurs in some but not in all patients with probable AD. Methods – We reviewed the SPECT scans of 220 patients presenting with cognitive impairment. Among them, 104 patients fulfilled NINCDS–ADRDA criteria for probable AD, 48 (32 women) with early onset (before age of 65) and 56 (40 women) with late onset of the symptoms. Dementia severity was assessed by the Mini‐Mental State Examination. The SPECT scans were classified by visual inspection blind to clinical diagnoses. Results – Bilateral parietotemporal hypoperfusion was more frequent in patients with severe AD, in those with early onset of the symptoms, and in men. Duration of symptoms, type of gamma‐camera or radiopharmaceutical agent used were not associated with this SPECT pattern. Conclusion – These findings may be useful in the clinical setting and point to heterogeneity of AD according to age at onset. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: SPECT in Alzheimer's disease:features associated with bilateral parietotemporal hypoperfusion.
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  Data: <searchLink fieldCode="AR" term="%22Nitrini%2C+R%2E%22">Nitrini, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Buchpiguel%2C+C%2E+A%2E%22">Buchpiguel, C. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Caramelli%2C+P%2E%22">Caramelli, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Bahia%2C+V%2E+S%2E%22">Bahia, V. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Mathias%2C+S%2E+C%2E%22">Mathias, S. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Nascimento%2C+C%2E+M%2E+R%2E%22">Nascimento, C. M. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Degenszajn%2C+J%2E%22">Degenszajn, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Caixeta%2C+L%2E%22">Caixeta, L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Mar2000, Vol. 101 Issue 3, p172-176. 5p. 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Cerebral+circulation%22">Cerebral circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink>
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  Data: Abstract Objective – To investigate why bilateral parietotemporal hypoperfusion, the typical SPECT pattern of Alzheimer's disease (AD), occurs in some but not in all patients with probable AD. Methods – We reviewed the SPECT scans of 220 patients presenting with cognitive impairment. Among them, 104 patients fulfilled NINCDS–ADRDA criteria for probable AD, 48 (32 women) with early onset (before age of 65) and 56 (40 women) with late onset of the symptoms. Dementia severity was assessed by the Mini‐Mental State Examination. The SPECT scans were classified by visual inspection blind to clinical diagnoses. Results – Bilateral parietotemporal hypoperfusion was more frequent in patients with severe AD, in those with early onset of the symptoms, and in men. Duration of symptoms, type of gamma‐camera or radiopharmaceutical agent used were not associated with this SPECT pattern. Conclusion – These findings may be useful in the clinical setting and point to heterogeneity of AD according to age at onset. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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