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Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood.

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Title: Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood.
Authors: Gatt, Justine M. (AUTHOR), Williams, Leanne M. (AUTHOR), Schofield, Peter R. (AUTHOR), Dobson‐Stone, Carol (AUTHOR), Paul, Robert H. (AUTHOR), Grieve, Stuart M. (AUTHOR), Clark, C. Richard (AUTHOR), Gordon, Evian (AUTHOR), Nemeroff, Charles B. (AUTHOR)
Source: Depression & Anxiety (1091-4269). Aug2010, Vol. 27 Issue 8, p752-759. 8p. 2 Color Photographs, 2 Charts, 1 Graph.
Subjects: Mental illness, Genetic research, Psychological stress, Diagnostic imaging, Magnetic resonance imaging, Mental depression
Abstract: Background: The risk for mental illnesses such as depression is increasingly conceptualized as the product of gene–environment interactions and their impact on brain structure and function. The role of serotonin 3A receptor gene (HTR3A -42C>T polymorphism) and its interaction with early life stress (ELS) was investigated in view of the receptor's localization to brain regions central to emotion processing. Methods: Fronto-limbic grey matter (GM) loss was measured using magnetic resonance imaging and assessed using voxel-based morphometry analysis in 397 nonclinical individuals from the Brain Resource International Database. Negative mood symptoms were also assessed. Results: The HTR3A CC genotype group, compared to the T carriers, demonstrated comparative loss to GM in hippocampal structures, which extended to the frontal cortices for those CC genotype individuals also exposed to ELS. Elevations in depressed mood were also evident. Conclusions: These findings suggest that the HTR3A CC genotype may be associated with alterations in brain structures central to emotion processing, particularly when exposed to stress, and further highlight the potential role of the serotonin system in the pathophysiology of affective disorders. In contrast, those individuals with the T allele, in particular the TT genotype, may be more protected from such alterations combined with minimal exposure to ELS events. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Impact of the HTR3A gene with early life trauma on emotional brain networks and depressed mood.
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  Data: <searchLink fieldCode="AR" term="%22Gatt%2C+Justine+M%2E%22">Gatt, Justine M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Williams%2C+Leanne+M%2E%22">Williams, Leanne M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schofield%2C+Peter+R%2E%22">Schofield, Peter R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dobson‐Stone%2C+Carol%22">Dobson‐Stone, Carol</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paul%2C+Robert+H%2E%22">Paul, Robert H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grieve%2C+Stuart+M%2E%22">Grieve, Stuart M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Clark%2C+C%2E+Richard%22">Clark, C. Richard</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gordon%2C+Evian%22">Gordon, Evian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nemeroff%2C+Charles+B%2E%22">Nemeroff, Charles B.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. Aug2010, Vol. 27 Issue 8, p752-759. 8p. 2 Color Photographs, 2 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+research%22">Genetic research</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: The risk for mental illnesses such as depression is increasingly conceptualized as the product of gene–environment interactions and their impact on brain structure and function. The role of serotonin 3A receptor gene (HTR3A -42C>T polymorphism) and its interaction with early life stress (ELS) was investigated in view of the receptor's localization to brain regions central to emotion processing. Methods: Fronto-limbic grey matter (GM) loss was measured using magnetic resonance imaging and assessed using voxel-based morphometry analysis in 397 nonclinical individuals from the Brain Resource International Database. Negative mood symptoms were also assessed. Results: The HTR3A CC genotype group, compared to the T carriers, demonstrated comparative loss to GM in hippocampal structures, which extended to the frontal cortices for those CC genotype individuals also exposed to ELS. Elevations in depressed mood were also evident. Conclusions: These findings suggest that the HTR3A CC genotype may be associated with alterations in brain structures central to emotion processing, particularly when exposed to stress, and further highlight the potential role of the serotonin system in the pathophysiology of affective disorders. In contrast, those individuals with the T allele, in particular the TT genotype, may be more protected from such alterations combined with minimal exposure to ELS events. Depression and Anxiety, 2010. © 2010 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
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  Label:
  Group: Ab
  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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