View in EDS HTML Full Text PDF Full Text

Melatonin: Pharmacological Aspects and Clinical Trends.

Saved in:
Bibliographic Details
Title: Melatonin: Pharmacological Aspects and Clinical Trends.
Authors: Rios, Emiliano Ricardo Vasconcelos (AUTHOR), Venâncio, Edith Teles (AUTHOR), Rocha, Nayrton Flávio Moura (AUTHOR), Woods, David John (AUTHOR), Vasconcelos, Silvania (AUTHOR), Macedo, Danielle (AUTHOR), Sousa, Francisca Cléa Florenço de (AUTHOR), Fonteles, Marta Maria de França (AUTHOR)
Source: International Journal of Neuroscience. Sep2010, Vol. 120 Issue 9, p583-590. 8p. 2 Diagrams.
Subjects: Melatonin, Pineal gland, Jet lag treatment, Sleep disorders treatment, Circadian rhythms, Sleep-wake cycle, Therapeutics
Abstract: Melatonin, N-acetyl-5-methoxytryptamine, the major hormone produced by the pineal gland under the influence of the dark/light cycle, has been shown to have a large number of therapeutic possibilities. It has been utilized in several countries for circadian rhythm disorders, sleep disturbances, jet lag, and sleep–wake cycle disturbances in blind people, and shift workers. In our mechanism of act, the Gi protein-coupled metabotropic melatonin receptors MT1 and MT2 are the primary mediators of the physiological actions of melatonin. This hormone plays an important role in the regulation of physiological and neuroendocrine functions, such as synchronization of seasonal reproductive rhythms and entrainment of circadian cycles. In addition to its chronobiological role, several pharmacological effects of melatonin have been reported in mammals including sedative, antioxidant, anxiolytic, antidepressant, anticonvulsant, and analgesic activities. There is some evidence from clinical trials that melatonin can be helpful in that event. Current trends of pharmacological functions of melatonin pointed out its use in the treatment of neurodegenerative and neoplastic diseases. These effects and uses of melatonin are mentioned but further confirmatory studies are needed in most of them. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 52902497
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Melatonin: Pharmacological Aspects and Clinical Trends.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Rios%2C+Emiliano+Ricardo+Vasconcelos%22">Rios, Emiliano Ricardo Vasconcelos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Venâncio%2C+Edith+Teles%22">Venâncio, Edith Teles</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rocha%2C+Nayrton+Flávio+Moura%22">Rocha, Nayrton Flávio Moura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Woods%2C+David+John%22">Woods, David John</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vasconcelos%2C+Silvania%22">Vasconcelos, Silvania</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Macedo%2C+Danielle%22">Macedo, Danielle</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sousa%2C+Francisca+Cléa+Florenço+de%22">Sousa, Francisca Cléa Florenço de</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fonteles%2C+Marta+Maria+de+França%22">Fonteles, Marta Maria de França</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Sep2010, Vol. 120 Issue 9, p583-590. 8p. 2 Diagrams.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Melatonin%22">Melatonin</searchLink><br /><searchLink fieldCode="DE" term="%22Pineal+gland%22">Pineal gland</searchLink><br /><searchLink fieldCode="DE" term="%22Jet+lag+treatment%22">Jet lag treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorders+treatment%22">Sleep disorders treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Circadian+rhythms%22">Circadian rhythms</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep-wake+cycle%22">Sleep-wake cycle</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Melatonin, N-acetyl-5-methoxytryptamine, the major hormone produced by the pineal gland under the influence of the dark/light cycle, has been shown to have a large number of therapeutic possibilities. It has been utilized in several countries for circadian rhythm disorders, sleep disturbances, jet lag, and sleep–wake cycle disturbances in blind people, and shift workers. In our mechanism of act, the Gi protein-coupled metabotropic melatonin receptors MT1 and MT2 are the primary mediators of the physiological actions of melatonin. This hormone plays an important role in the regulation of physiological and neuroendocrine functions, such as synchronization of seasonal reproductive rhythms and entrainment of circadian cycles. In addition to its chronobiological role, several pharmacological effects of melatonin have been reported in mammals including sedative, antioxidant, anxiolytic, antidepressant, anticonvulsant, and analgesic activities. There is some evidence from clinical trials that melatonin can be helpful in that event. Current trends of pharmacological functions of melatonin pointed out its use in the treatment of neurodegenerative and neoplastic diseases. These effects and uses of melatonin are mentioned but further confirmatory studies are needed in most of them. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=52902497
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3109/00207454.2010.492921
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 583
    Subjects:
      – SubjectFull: Melatonin
        Type: general
      – SubjectFull: Pineal gland
        Type: general
      – SubjectFull: Jet lag treatment
        Type: general
      – SubjectFull: Sleep disorders treatment
        Type: general
      – SubjectFull: Circadian rhythms
        Type: general
      – SubjectFull: Sleep-wake cycle
        Type: general
      – SubjectFull: Therapeutics
        Type: general
    Titles:
      – TitleFull: Melatonin: Pharmacological Aspects and Clinical Trends.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Rios, Emiliano Ricardo Vasconcelos
      – PersonEntity:
          Name:
            NameFull: Venâncio, Edith Teles
      – PersonEntity:
          Name:
            NameFull: Rocha, Nayrton Flávio Moura
      – PersonEntity:
          Name:
            NameFull: Woods, David John
      – PersonEntity:
          Name:
            NameFull: Vasconcelos, Silvania
      – PersonEntity:
          Name:
            NameFull: Macedo, Danielle
      – PersonEntity:
          Name:
            NameFull: Sousa, Francisca Cléa Florenço de
      – PersonEntity:
          Name:
            NameFull: Fonteles, Marta Maria de França
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: Sep2010
              Type: published
              Y: 2010
          Identifiers:
            – Type: issn-print
              Value: 00207454
          Numbering:
            – Type: volume
              Value: 120
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: International Journal of Neuroscience
              Type: main
ResultId 1