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Patients with thrombolysed stroke in Vietnam have an excellent outcome: results from the Vietnam Thrombolysis Registry.

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Title: Patients with thrombolysed stroke in Vietnam have an excellent outcome: results from the Vietnam Thrombolysis Registry.
Authors: Nguyen, T. H., Truong, A. L. T., Ngo, M. B., Bui, C. T. Q., Dinh, Q. V., Doan, T. C., Nguyen, L. T. K., Phan, T. C., Phan, M. V., Nguyen, T. V., Le, T. V.
Source: European Journal of Neurology. Sep2010, Vol. 17 Issue 9, p1188-1192. 5p. 3 Charts.
Subjects: Thrombolytic therapy, Hospitals, National Institute of Neurological Disorders & Stroke (U.S.), Hemorrhagic diseases, Disease complications
Geographic Terms: Ho Chi Minh City (Vietnam), Vietnam, United States
Abstract: Background and purpose: We present the early experience in thrombolysis in three major centers of Ho Chi Minh city, namely 115 People Hospital, Gia Dinh Hospital, and An Binh Hospital. Methods: A prospective study of consecutive patients treated with intravenous tPA with a treatment protocol similar to that of the National Institute of Neurological Disorders and Stroke (NINDS) trial. National Institutes of Health Stroke Scale (NIHSS) scores on admission and Modified Rankin Scale (MRS) scores at 3 months were measured for all patients. Intracranial and systemic hemorrhagic complications were recorded. Result: A total of 121 of 6171 (2%) patients with acute IS received thrombolysis over 3 years. Mean age was 57 years (range 18–78) and initial median NIHSS score was 12 (range 5–23). The mean delay between symptom onset and treatment was 143 min (range 50–210). Seventy-three (60.3%) patients received the standard dose with the remaining 48 patients (36.9%) treated with a lower dose, a mean calculated dose of 0.62 mg/kg (range, 0.6–0.86 mg/kg). Over half (56.3%) of the patients receiving low dose achieved functional independence (mRS score 0–1) at 3 months compared with 34.2% in the standard-dose group ( P = 0.01). The 3-month mortality rate was also higher in the standard-dose group (2.1% vs. 12.5% with standard-dose tPA; P = 0.04). Symptomatic intracranial hemorrhage was noted in four patients of standard-dose group and one patient of low-dose group ( P = 0.36). Conclusion: Intravenous thrombolysis, particularly in a lower dose, is safe and feasible in the treatment of acute IS in our selected Vietnamese population. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Patients with thrombolysed stroke in Vietnam have an excellent outcome: results from the Vietnam Thrombolysis Registry.
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  Data: <searchLink fieldCode="AR" term="%22Nguyen%2C+T%2E+H%2E%22">Nguyen, T. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Truong%2C+A%2E+L%2E+T%2E%22">Truong, A. L. T.</searchLink><br /><searchLink fieldCode="AR" term="%22Ngo%2C+M%2E+B%2E%22">Ngo, M. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Bui%2C+C%2E+T%2E+Q%2E%22">Bui, C. T. Q.</searchLink><br /><searchLink fieldCode="AR" term="%22Dinh%2C+Q%2E+V%2E%22">Dinh, Q. V.</searchLink><br /><searchLink fieldCode="AR" term="%22Doan%2C+T%2E+C%2E%22">Doan, T. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Nguyen%2C+L%2E+T%2E+K%2E%22">Nguyen, L. T. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Phan%2C+T%2E+C%2E%22">Phan, T. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Phan%2C+M%2E+V%2E%22">Phan, M. V.</searchLink><br /><searchLink fieldCode="AR" term="%22Nguyen%2C+T%2E+V%2E%22">Nguyen, T. V.</searchLink><br /><searchLink fieldCode="AR" term="%22Le%2C+T%2E+V%2E%22">Le, T. V.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Sep2010, Vol. 17 Issue 9, p1188-1192. 5p. 3 Charts.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Thrombolytic+therapy%22">Thrombolytic therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Hospitals%22">Hospitals</searchLink><br /><searchLink fieldCode="DE" term="%22National+Institute+of+Neurological+Disorders+%26+Stroke+%28U%2ES%2E%29%22">National Institute of Neurological Disorders & Stroke (U.S.)</searchLink><br /><searchLink fieldCode="DE" term="%22Hemorrhagic+diseases%22">Hemorrhagic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Ho+Chi+Minh+City+%28Vietnam%29%22">Ho Chi Minh City (Vietnam)</searchLink><br /><searchLink fieldCode="DE" term="%22Vietnam%22">Vietnam</searchLink><br /><searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose: We present the early experience in thrombolysis in three major centers of Ho Chi Minh city, namely 115 People Hospital, Gia Dinh Hospital, and An Binh Hospital. Methods: A prospective study of consecutive patients treated with intravenous tPA with a treatment protocol similar to that of the National Institute of Neurological Disorders and Stroke (NINDS) trial. National Institutes of Health Stroke Scale (NIHSS) scores on admission and Modified Rankin Scale (MRS) scores at 3 months were measured for all patients. Intracranial and systemic hemorrhagic complications were recorded. Result: A total of 121 of 6171 (2%) patients with acute IS received thrombolysis over 3 years. Mean age was 57 years (range 18–78) and initial median NIHSS score was 12 (range 5–23). The mean delay between symptom onset and treatment was 143 min (range 50–210). Seventy-three (60.3%) patients received the standard dose with the remaining 48 patients (36.9%) treated with a lower dose, a mean calculated dose of 0.62 mg/kg (range, 0.6–0.86 mg/kg). Over half (56.3%) of the patients receiving low dose achieved functional independence (mRS score 0–1) at 3 months compared with 34.2% in the standard-dose group ( P = 0.01). The 3-month mortality rate was also higher in the standard-dose group (2.1% vs. 12.5% with standard-dose tPA; P = 0.04). Symptomatic intracranial hemorrhage was noted in four patients of standard-dose group and one patient of low-dose group ( P = 0.36). Conclusion: Intravenous thrombolysis, particularly in a lower dose, is safe and feasible in the treatment of acute IS in our selected Vietnamese population. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1468-1331.2010.02995.x
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      – Code: eng
        Text: English
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      – SubjectFull: Thrombolytic therapy
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      – SubjectFull: Hospitals
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