View in EDS HTML Full Text PDF Full Text

Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice.

Saved in:
Bibliographic Details
Title: Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice.
Authors: Viollet, C. (AUTHOR), Vaillend, C. (AUTHOR), Videau, C. (AUTHOR), Bluet‐Pajot, M. T. (AUTHOR), Ungerer, A. (AUTHOR), L'héritier, A. (AUTHOR), Kopp, C. (AUTHOR), Potier, B. (AUTHOR), Billard, J. ‐M. (AUTHOR), Schaeffer, J. (AUTHOR), Smith, R. G. (AUTHOR), Rohrer, S. P. (AUTHOR), Wilkinson, H. (AUTHOR), Zheng, H. (AUTHOR), Epelbaum, J. (AUTHOR)
Source: European Journal of Neuroscience. Oct2000, Vol. 12 Issue 10, p3761-3770. 10p. 2 Charts.
Subjects: Somatostatin, Neurosciences
Abstract: Somatostatin (SRIF) controls many physiological and pathological processes in the central nervous system but the respective roles of the five receptor isotypes (sst1-5) that mediate its effects are yet to be defined. In the present study, we attempted to identify functions of the sst2 receptor using mice with no functional copy of this gene (sst2 KO mice). In contrast with control 129Sv/C57Bl6 mice, sst2 mRNA was no longer detectable in the brain of sst2 KO mice; [sup 125]l-labeled Tyr[sub 0]DTrp[sub 8]-SRIF14 binding was also greatly reduced in almost all brain structures except for the hippocampal CA1 area, demonstrating that sst2 accounts for most SRIF binding in mouse brain. Invalidation of this subtype generated an increased anxiety-related behaviour in a number of behavioural paradigms, while locomotor and exploratory activity was decreased in stress-inducing situations. No major motor defects could be detected, sst2 KO mice also displayed increased release of pituitary ACTH, a main regulator of the stress response. Thus, somatostatin, via sst2 receptor isotype pathways, appears involved in the modulation of locomotor, exploratory and emotional reactivity in mice. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 5470689
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Viollet%2C+C%2E%22">Viollet, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vaillend%2C+C%2E%22">Vaillend, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Videau%2C+C%2E%22">Videau, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bluet‐Pajot%2C+M%2E+T%2E%22">Bluet‐Pajot, M. T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ungerer%2C+A%2E%22">Ungerer, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22L'héritier%2C+A%2E%22">L'héritier, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kopp%2C+C%2E%22">Kopp, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Potier%2C+B%2E%22">Potier, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Billard%2C+J%2E+‐M%2E%22">Billard, J. ‐M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schaeffer%2C+J%2E%22">Schaeffer, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Smith%2C+R%2E+G%2E%22">Smith, R. G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rohrer%2C+S%2E+P%2E%22">Rohrer, S. P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilkinson%2C+H%2E%22">Wilkinson, H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+H%2E%22">Zheng, H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Epelbaum%2C+J%2E%22">Epelbaum, J.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Oct2000, Vol. 12 Issue 10, p3761-3770. 10p. 2 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Somatostatin%22">Somatostatin</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%22">Neurosciences</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Somatostatin (SRIF) controls many physiological and pathological processes in the central nervous system but the respective roles of the five receptor isotypes (sst1-5) that mediate its effects are yet to be defined. In the present study, we attempted to identify functions of the sst2 receptor using mice with no functional copy of this gene (sst2 KO mice). In contrast with control 129Sv/C57Bl6 mice, sst2 mRNA was no longer detectable in the brain of sst2 KO mice; [sup 125]l-labeled Tyr[sub 0]DTrp[sub 8]-SRIF14 binding was also greatly reduced in almost all brain structures except for the hippocampal CA1 area, demonstrating that sst2 accounts for most SRIF binding in mouse brain. Invalidation of this subtype generated an increased anxiety-related behaviour in a number of behavioural paradigms, while locomotor and exploratory activity was decreased in stress-inducing situations. No major motor defects could be detected, sst2 KO mice also displayed increased release of pituitary ACTH, a main regulator of the stress response. Thus, somatostatin, via sst2 receptor isotype pathways, appears involved in the modulation of locomotor, exploratory and emotional reactivity in mice. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=5470689
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1046/j.1460-9568.2000.00249.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 3761
    Subjects:
      – SubjectFull: Somatostatin
        Type: general
      – SubjectFull: Neurosciences
        Type: general
    Titles:
      – TitleFull: Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Viollet, C.
      – PersonEntity:
          Name:
            NameFull: Vaillend, C.
      – PersonEntity:
          Name:
            NameFull: Videau, C.
      – PersonEntity:
          Name:
            NameFull: Bluet‐Pajot, M. T.
      – PersonEntity:
          Name:
            NameFull: Ungerer, A.
      – PersonEntity:
          Name:
            NameFull: L'héritier, A.
      – PersonEntity:
          Name:
            NameFull: Kopp, C.
      – PersonEntity:
          Name:
            NameFull: Potier, B.
      – PersonEntity:
          Name:
            NameFull: Billard, J. ‐M.
      – PersonEntity:
          Name:
            NameFull: Schaeffer, J.
      – PersonEntity:
          Name:
            NameFull: Smith, R. G.
      – PersonEntity:
          Name:
            NameFull: Rohrer, S. P.
      – PersonEntity:
          Name:
            NameFull: Wilkinson, H.
      – PersonEntity:
          Name:
            NameFull: Zheng, H.
      – PersonEntity:
          Name:
            NameFull: Epelbaum, J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: Oct2000
              Type: published
              Y: 2000
          Identifiers:
            – Type: issn-print
              Value: 0953816X
          Numbering:
            – Type: volume
              Value: 12
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: European Journal of Neuroscience
              Type: main
ResultId 1