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Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial.

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Title: Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial.
Authors: Cornelissen, VA, Defoor, JGM, Stevens, A., Schepers, D., Hespel, P., Decramer, M., Mortelmans, L., Dobbels, F., Vanhaecke, J., Fagard, RH, Vanhees, L.
Source: Clinical Rehabilitation. Nov2010, Vol. 24 Issue 11, p988-999. 12p. 1 Diagram, 4 Charts.
Subjects: Creatine, Analysis of variance, Cardiac output, Chi-squared test, Clinical trials, Computer software, Congestive heart failure, Coronary disease, Cycling, Dietary supplements, Electrocardiography, Exercise, Fisher exact test, Health surveys, Cardiac rehabilitation, Heart beat, Isokinetic exercise, Muscle contraction, Muscle strength, Physical fitness, Quality of life, Questionnaires, Statistical sampling, T-test (Statistics), Work measurement, Data analysis, Aerobic capacity, Cooldown, Oxygen consumption, Medical rehabilitation, Therapeutics
Geographic Terms: Netherlands
Abstract: Objective: To investigate the effect of oral creatine supplementation in conjunction with an exercise programme on physical fitness in patients with coronary artery disease or chronic heart failure.Design: Single centre double-blind randomized placebo controlled trial.Setting: Cardiac rehabilitation centre.Subjects and intervention: 70 (4 women) cardiac patients (age 57.5 (8.4) years) were randomized to a placebo (n = 37) or creatine (n = 33) treatment for three months. Combined aerobic endurance and resistance training (three sessions/ week) was performed during supplementation.Main Measures: Aerobic power was determined during graded bicycle testing, knee extensor peak isometric and isokinetic strength, endurance and recovery were assessed by an isokinetic dynamometer, and health related quality of life was evaluated with the SF-36 and MacNew Heart Disease questionnaires. In addition, blood samples were taken after an overnight fast and 24 hour urinary collection was performed.Results: At baseline there were no significant differences between both groups. We observed main time effects for aerobic power, muscle performance, health related quality of life, high density lipoprotein cholesterol and triglycerides (pre vs post; P<0.05 for all). However, changes after training were similar between placebo group and creatine group (P>0.05). Further, no detrimental effect on renal or liver function was observed nor were there any reports of side effects.Conclusion: Oral creatine supplementation in combination with exercise training does not exert any additional effect on the improvement in physical performance, health related quality of life, lipid profile in patients with coronary artery disease or chronic heart failure than exercise training alone. [ABSTRACT FROM PUBLISHER]
Copyright of Clinical Rehabilitation is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Clinical+Rehabilitation%22&quot;&gt;Clinical Rehabilitation&lt;/searchLink&gt;. Nov2010, Vol. 24 Issue 11, p988-999. 12p. 1 Diagram, 4 Charts.
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  Data: Objective: To investigate the effect of oral creatine supplementation in conjunction with an exercise programme on physical fitness in patients with coronary artery disease or chronic heart failure.Design: Single centre double-blind randomized placebo controlled trial.Setting: Cardiac rehabilitation centre.Subjects and intervention: 70 (4 women) cardiac patients (age 57.5 (8.4) years) were randomized to a placebo (n = 37) or creatine (n = 33) treatment for three months. Combined aerobic endurance and resistance training (three sessions/ week) was performed during supplementation.Main Measures: Aerobic power was determined during graded bicycle testing, knee extensor peak isometric and isokinetic strength, endurance and recovery were assessed by an isokinetic dynamometer, and health related quality of life was evaluated with the SF-36 and MacNew Heart Disease questionnaires. In addition, blood samples were taken after an overnight fast and 24 hour urinary collection was performed.Results: At baseline there were no significant differences between both groups. We observed main time effects for aerobic power, muscle performance, health related quality of life, high density lipoprotein cholesterol and triglycerides (pre vs post; P&lt;0.05 for all). However, changes after training were similar between placebo group and creatine group (P&gt;0.05). Further, no detrimental effect on renal or liver function was observed nor were there any reports of side effects.Conclusion: Oral creatine supplementation in combination with exercise training does not exert any additional effect on the improvement in physical performance, health related quality of life, lipid profile in patients with coronary artery disease or chronic heart failure than exercise training alone. [ABSTRACT FROM PUBLISHER]
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  Data: &lt;i&gt;Copyright of Clinical Rehabilitation is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1177/0269215510367995
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        Text: English
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      – SubjectFull: Creatine
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Cardiac output
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      – SubjectFull: Chi-squared test
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      – SubjectFull: Clinical trials
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      – SubjectFull: Congestive heart failure
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      – SubjectFull: Coronary disease
        Type: general
      – SubjectFull: Cycling
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      – SubjectFull: Dietary supplements
        Type: general
      – SubjectFull: Electrocardiography
        Type: general
      – SubjectFull: Exercise
        Type: general
      – SubjectFull: Fisher exact test
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      – SubjectFull: Health surveys
        Type: general
      – SubjectFull: Cardiac rehabilitation
        Type: general
      – SubjectFull: Heart beat
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      – SubjectFull: Isokinetic exercise
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      – SubjectFull: Physical fitness
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      – SubjectFull: Oxygen consumption
        Type: general
      – SubjectFull: Medical rehabilitation
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Netherlands
        Type: general
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      – TitleFull: Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial.
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              Text: Nov2010
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