Sound stimulation modulates high-threshold K currents in mouse auditory brainstem neurons K. E. Leão et al. Sound stimulation regulates potassium currents.
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| Title: | Sound stimulation modulates high-threshold K currents in mouse auditory brainstem neurons K. E. Leão et al. Sound stimulation regulates potassium currents. |
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| Authors: | Leão, Katarina E. (AUTHOR), Leão, Richardson N. (AUTHOR), Deardorff, Adam S. (AUTHOR), Garrett, Andrew (AUTHOR), Fyffe, Robert (AUTHOR), Walmsley, Bruce (AUTHOR) |
| Source: | European Journal of Neuroscience. Nov2010, Vol. 32 Issue 10, p1658-1667. 10p. |
| Subjects: | Neural stimulation, Brain stem, Patch-clamp techniques (Electrophysiology), Action potentials, Auditory perception, Potassium channels, Laboratory mice |
| Abstract: | The auditory system provides a valuable experimental model to investigate the role of sensory activity in regulating neuronal membrane properties. In this study, we have investigated the role of activity directly by measuring changes in medial nucleus of the trapezoid body (MNTB) neurons in normal hearing mice subjected to 1-h sound stimulation. Broadband (4-12 kHz) chirps were used to activate MNTB neurons tonotopically restricted to the lateral MNTB, as confirmed by c-Fos-immunoreactivity. Following 1-h sound stimulation a substantial increase in Kv3.1b-immunoreactivity was measured in the lateral region of the MNTB, which lasted for 2 h before returning to control levels. Electrophysiological patch-clamp recordings in brainstem slices revealed an increase in high-threshold potassium currents in the lateral MNTB of sound-stimulated mice. Current-clamp and dynamic-clamp experiments showed that MNTB cells from the sound-stimulated mice were able to maintain briefer action potentials during high-frequency firing than cells from control mice. These results provide evidence that acoustically driven auditory activity can selectively regulate high-threshold potassium currents in the MNTB of normal hearing mice, likely due to an increased membrane expression of Kv3.1b channels. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 55170902 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sound stimulation modulates high-threshold K currents in mouse auditory brainstem neurons K. E. Leão et al. Sound stimulation regulates potassium currents. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Leão%2C+Katarina+E%2E%22">Leão, Katarina E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leão%2C+Richardson+N%2E%22">Leão, Richardson N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Deardorff%2C+Adam+S%2E%22">Deardorff, Adam S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garrett%2C+Andrew%22">Garrett, Andrew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fyffe%2C+Robert%22">Fyffe, Robert</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Walmsley%2C+Bruce%22">Walmsley, Bruce</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Nov2010, Vol. 32 Issue 10, p1658-1667. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neural+stimulation%22">Neural stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+stem%22">Brain stem</searchLink><br /><searchLink fieldCode="DE" term="%22Patch-clamp+techniques+%28Electrophysiology%29%22">Patch-clamp techniques (Electrophysiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Action+potentials%22">Action potentials</searchLink><br /><searchLink fieldCode="DE" term="%22Auditory+perception%22">Auditory perception</searchLink><br /><searchLink fieldCode="DE" term="%22Potassium+channels%22">Potassium channels</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The auditory system provides a valuable experimental model to investigate the role of sensory activity in regulating neuronal membrane properties. In this study, we have investigated the role of activity directly by measuring changes in medial nucleus of the trapezoid body (MNTB) neurons in normal hearing mice subjected to 1-h sound stimulation. Broadband (4-12 kHz) chirps were used to activate MNTB neurons tonotopically restricted to the lateral MNTB, as confirmed by c-Fos-immunoreactivity. Following 1-h sound stimulation a substantial increase in Kv3.1b-immunoreactivity was measured in the lateral region of the MNTB, which lasted for 2 h before returning to control levels. Electrophysiological patch-clamp recordings in brainstem slices revealed an increase in high-threshold potassium currents in the lateral MNTB of sound-stimulated mice. Current-clamp and dynamic-clamp experiments showed that MNTB cells from the sound-stimulated mice were able to maintain briefer action potentials during high-frequency firing than cells from control mice. These results provide evidence that acoustically driven auditory activity can selectively regulate high-threshold potassium currents in the MNTB of normal hearing mice, likely due to an increased membrane expression of Kv3.1b channels. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1460-9568.2010.07437.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1658 Subjects: – SubjectFull: Neural stimulation Type: general – SubjectFull: Brain stem Type: general – SubjectFull: Patch-clamp techniques (Electrophysiology) Type: general – SubjectFull: Action potentials Type: general – SubjectFull: Auditory perception Type: general – SubjectFull: Potassium channels Type: general – SubjectFull: Laboratory mice Type: general Titles: – TitleFull: Sound stimulation modulates high-threshold K currents in mouse auditory brainstem neurons K. E. Leão et al. Sound stimulation regulates potassium currents. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Leão, Katarina E. – PersonEntity: Name: NameFull: Leão, Richardson N. – PersonEntity: Name: NameFull: Deardorff, Adam S. – PersonEntity: Name: NameFull: Garrett, Andrew – PersonEntity: Name: NameFull: Fyffe, Robert – PersonEntity: Name: NameFull: Walmsley, Bruce IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 11 Text: Nov2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 32 – Type: issue Value: 10 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
