Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages.
Saved in:
| Title: | Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages. |
|---|---|
| Authors: | Ginhoux, Florent, Greter, Melanie, Leboeuf, Marylene, Nandi, Sayan, See, Peter, Gokhan, Solen, Mehler, Mark F., Conway, Simon J., Lai Guan Ng, Stanley, E. Richard, Samokhvalov, Igor M., Merad, Miriam |
| Source: | Science (pre-March 2025). 11/5/2010, Vol. 330 Issue 6005, p841-845. 5p. |
| Subjects: | Microglia, Central nervous system -- Immunology, Macrophages, Neurodegeneration, Encephalitis, Hematopoietic stem cells, Homeostasis |
| Abstract: | Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, the origin of adult microglia remains controversial. We show that postnatal hematopoietic progenitors do not significantly contribute to microglia homeostasis in the adult brain. In contrast to many macrophage populations, we show that microglia develop in mice that lack colony stimulating factor-1 (CSF-1) but are absent in CSF-1 receptor-deficient mice. In vivo lineage tracing studies established that adult microglia derive from primitive myeloid progenitors that arise before embryonic day 8. These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 55259876 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ginhoux%2C+Florent%22">Ginhoux, Florent</searchLink><br /><searchLink fieldCode="AR" term="%22Greter%2C+Melanie%22">Greter, Melanie</searchLink><br /><searchLink fieldCode="AR" term="%22Leboeuf%2C+Marylene%22">Leboeuf, Marylene</searchLink><br /><searchLink fieldCode="AR" term="%22Nandi%2C+Sayan%22">Nandi, Sayan</searchLink><br /><searchLink fieldCode="AR" term="%22See%2C+Peter%22">See, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Gokhan%2C+Solen%22">Gokhan, Solen</searchLink><br /><searchLink fieldCode="AR" term="%22Mehler%2C+Mark+F%2E%22">Mehler, Mark F.</searchLink><br /><searchLink fieldCode="AR" term="%22Conway%2C+Simon+J%2E%22">Conway, Simon J.</searchLink><br /><searchLink fieldCode="AR" term="%22Lai+Guan+Ng%22">Lai Guan Ng</searchLink><br /><searchLink fieldCode="AR" term="%22Stanley%2C+E%2E+Richard%22">Stanley, E. Richard</searchLink><br /><searchLink fieldCode="AR" term="%22Samokhvalov%2C+Igor+M%2E%22">Samokhvalov, Igor M.</searchLink><br /><searchLink fieldCode="AR" term="%22Merad%2C+Miriam%22">Merad, Miriam</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 11/5/2010, Vol. 330 Issue 6005, p841-845. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Microglia%22">Microglia</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system+--+Immunology%22">Central nervous system -- Immunology</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophages%22">Macrophages</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodegeneration%22">Neurodegeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Encephalitis%22">Encephalitis</searchLink><br /><searchLink fieldCode="DE" term="%22Hematopoietic+stem+cells%22">Hematopoietic stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Homeostasis%22">Homeostasis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, the origin of adult microglia remains controversial. We show that postnatal hematopoietic progenitors do not significantly contribute to microglia homeostasis in the adult brain. In contrast to many macrophage populations, we show that microglia develop in mice that lack colony stimulating factor-1 (CSF-1) but are absent in CSF-1 receptor-deficient mice. In vivo lineage tracing studies established that adult microglia derive from primitive myeloid progenitors that arise before embryonic day 8. These results identify microglia as an ontogenically distinct population in the mononuclear phagocyte system and have implications for the use of embryonically derived microglial progenitors for the treatment of various brain disorders. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=55259876 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.1194637 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 841 Subjects: – SubjectFull: Microglia Type: general – SubjectFull: Central nervous system -- Immunology Type: general – SubjectFull: Macrophages Type: general – SubjectFull: Neurodegeneration Type: general – SubjectFull: Encephalitis Type: general – SubjectFull: Hematopoietic stem cells Type: general – SubjectFull: Homeostasis Type: general Titles: – TitleFull: Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ginhoux, Florent – PersonEntity: Name: NameFull: Greter, Melanie – PersonEntity: Name: NameFull: Leboeuf, Marylene – PersonEntity: Name: NameFull: Nandi, Sayan – PersonEntity: Name: NameFull: See, Peter – PersonEntity: Name: NameFull: Gokhan, Solen – PersonEntity: Name: NameFull: Mehler, Mark F. – PersonEntity: Name: NameFull: Conway, Simon J. – PersonEntity: Name: NameFull: Lai Guan Ng – PersonEntity: Name: NameFull: Stanley, E. Richard – PersonEntity: Name: NameFull: Samokhvalov, Igor M. – PersonEntity: Name: NameFull: Merad, Miriam IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 11 Text: 11/5/2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 330 – Type: issue Value: 6005 Titles: – TitleFull: Science (pre-March 2025) Type: main |
| ResultId | 1 |
