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TRIM24 links a non-canonical histone signature to breast cancer.

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Title: TRIM24 links a non-canonical histone signature to breast cancer.
Authors: Wen-Wei Tsai, Zhanxin Wang, Yiu, Teresa T., Akdemir, Kadir C., Xia, Weiya, Winter, Stefan, Tsai, Cheng-Yu, Xiaobin Shi, Schwarzer, Dirk, Plunkett, William, Aronow, Bruce, Gozani, Or, Fischle, Wolfgang, Mien-Chie Hung, Patel, Dinshaw J., Barton, Michelle Craig
Source: Nature. 12/16/2010, Vol. 468 Issue 7326, p927-932. 6p. 1 Diagram, 4 Graphs.
Subjects: Histones, Gene expression, Chromatin, Carcinogenesis, Cancer pathophysiology, Cellular pathology, Bromodomain-containing proteins
Abstract: Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes. Here we report that chromatin regulator tripartite motif-containing 24 (TRIM24) functions in humans as a reader of dual histone marks by means of tandem plant homeodomain (PHD) and bromodomain (Bromo) regions. The three-dimensional structure of the PHD-Bromo region of TRIM24 revealed a single functional unit for combinatorial recognition of unmodified H3K4 (that is, histone H3 unmodified at lysine 4, H3K4me0) and acetylated H3K23 (histone H3 acetylated at lysine 23, H3K23ac) within the same histone tail. TRIM24 binds chromatin and oestrogen receptor to activate oestrogen-dependent genes associated with cellular proliferation and tumour development. Aberrant expression of TRIM24 negatively correlates with survival of breast cancer patients. The PHD-Bromo of TRIM24 provides a structural rationale for chromatin activation through a non-canonical histone signature, establishing a new route by which chromatin readers may influence cancer pathogenesis. [ABSTRACT FROM AUTHOR]
Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: TRIM24 links a non-canonical histone signature to breast cancer.
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  Data: <searchLink fieldCode="AR" term="%22Wen-Wei+Tsai%22">Wen-Wei Tsai</searchLink><br /><searchLink fieldCode="AR" term="%22Zhanxin+Wang%22">Zhanxin Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Yiu%2C+Teresa+T%2E%22">Yiu, Teresa T.</searchLink><br /><searchLink fieldCode="AR" term="%22Akdemir%2C+Kadir+C%2E%22">Akdemir, Kadir C.</searchLink><br /><searchLink fieldCode="AR" term="%22Xia%2C+Weiya%22">Xia, Weiya</searchLink><br /><searchLink fieldCode="AR" term="%22Winter%2C+Stefan%22">Winter, Stefan</searchLink><br /><searchLink fieldCode="AR" term="%22Tsai%2C+Cheng-Yu%22">Tsai, Cheng-Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaobin+Shi%22">Xiaobin Shi</searchLink><br /><searchLink fieldCode="AR" term="%22Schwarzer%2C+Dirk%22">Schwarzer, Dirk</searchLink><br /><searchLink fieldCode="AR" term="%22Plunkett%2C+William%22">Plunkett, William</searchLink><br /><searchLink fieldCode="AR" term="%22Aronow%2C+Bruce%22">Aronow, Bruce</searchLink><br /><searchLink fieldCode="AR" term="%22Gozani%2C+Or%22">Gozani, Or</searchLink><br /><searchLink fieldCode="AR" term="%22Fischle%2C+Wolfgang%22">Fischle, Wolfgang</searchLink><br /><searchLink fieldCode="AR" term="%22Mien-Chie+Hung%22">Mien-Chie Hung</searchLink><br /><searchLink fieldCode="AR" term="%22Patel%2C+Dinshaw+J%2E%22">Patel, Dinshaw J.</searchLink><br /><searchLink fieldCode="AR" term="%22Barton%2C+Michelle+Craig%22">Barton, Michelle Craig</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Histones%22">Histones</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Chromatin%22">Chromatin</searchLink><br /><searchLink fieldCode="DE" term="%22Carcinogenesis%22">Carcinogenesis</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+pathophysiology%22">Cancer pathophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+pathology%22">Cellular pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Bromodomain-containing+proteins%22">Bromodomain-containing proteins</searchLink>
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  Data: Recognition of modified histone species by distinct structural domains within 'reader' proteins plays a critical role in the regulation of gene expression. Readers that simultaneously recognize histones with multiple marks allow transduction of complex chromatin modification patterns into specific biological outcomes. Here we report that chromatin regulator tripartite motif-containing 24 (TRIM24) functions in humans as a reader of dual histone marks by means of tandem plant homeodomain (PHD) and bromodomain (Bromo) regions. The three-dimensional structure of the PHD-Bromo region of TRIM24 revealed a single functional unit for combinatorial recognition of unmodified H3K4 (that is, histone H3 unmodified at lysine 4, H3K4me0) and acetylated H3K23 (histone H3 acetylated at lysine 23, H3K23ac) within the same histone tail. TRIM24 binds chromatin and oestrogen receptor to activate oestrogen-dependent genes associated with cellular proliferation and tumour development. Aberrant expression of TRIM24 negatively correlates with survival of breast cancer patients. The PHD-Bromo of TRIM24 provides a structural rationale for chromatin activation through a non-canonical histone signature, establishing a new route by which chromatin readers may influence cancer pathogenesis. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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