The value of cortical stimulation applied to the surgery of malignant gliomas in language areas.
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| Title: | The value of cortical stimulation applied to the surgery of malignant gliomas in language areas. |
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| Authors: | Signorelli, F., Guyotat, J., Isnard, J., Schneider, F., Mohammedi, R., Bret, P. |
| Source: | Neurological Sciences. Feb2001, Vol. 22 Issue 1, p3-10. 8p. 2 Diagrams, 2 Charts. |
| Subjects: | Gliomas, Neural stimulation |
| Abstract: | This study analyzes the utility of peroperative cortical language mapping applied to the surgery of high-grade gliomas situated within or in close vicinity to speech areas. Fifteen consecutive patients harboring high-grade gliomas located in the dominant hemisphere, causing regressive or minor language troubles, underwent awake craniotomy in our institution between June 1998 and April 2000. The technique of cortical stimulation under local anesthesia for language mapping, initially described by Ojemann and colleagues, was applied with some modifications. All patients tolerated awake craniotomy except one, who was intubated after the mapping procedure. Mapping results confirmed a high variability in location of language sites. It was possible to achieve a gross total tumor removal in all cases. Nine patients (60%) exhibited a transient postoperative aggravation. Two patients (13%) presented permanent phasic aggravation. One patient died 16 days after surgery from pulmonary embolism. Five patients died for tumor progression, with a mean survival time of 16.4 months and a median high-quality survival period of 14.2 months. With a mean follow-up of 9.9 months (range, 18-6 months), the 9 survivors are recurrence-free and reveal no significant change in linguistic abilities. This technique is well tolerated and consents to maximize the extent of surgical removal while minimizing the risks of permanent postoperative deficits. This results in an improvement of survival and quality of life. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 5591375 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The value of cortical stimulation applied to the surgery of malignant gliomas in language areas. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Signorelli%2C+F%2E%22">Signorelli, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Guyotat%2C+J%2E%22">Guyotat, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Isnard%2C+J%2E%22">Isnard, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Schneider%2C+F%2E%22">Schneider, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Mohammedi%2C+R%2E%22">Mohammedi, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Bret%2C+P%2E%22">Bret, P.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Feb2001, Vol. 22 Issue 1, p3-10. 8p. 2 Diagrams, 2 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Gliomas%22">Gliomas</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+stimulation%22">Neural stimulation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This study analyzes the utility of peroperative cortical language mapping applied to the surgery of high-grade gliomas situated within or in close vicinity to speech areas. Fifteen consecutive patients harboring high-grade gliomas located in the dominant hemisphere, causing regressive or minor language troubles, underwent awake craniotomy in our institution between June 1998 and April 2000. The technique of cortical stimulation under local anesthesia for language mapping, initially described by Ojemann and colleagues, was applied with some modifications. All patients tolerated awake craniotomy except one, who was intubated after the mapping procedure. Mapping results confirmed a high variability in location of language sites. It was possible to achieve a gross total tumor removal in all cases. Nine patients (60%) exhibited a transient postoperative aggravation. Two patients (13%) presented permanent phasic aggravation. One patient died 16 days after surgery from pulmonary embolism. Five patients died for tumor progression, with a mean survival time of 16.4 months and a median high-quality survival period of 14.2 months. With a mean follow-up of 9.9 months (range, 18-6 months), the 9 survivors are recurrence-free and reveal no significant change in linguistic abilities. This technique is well tolerated and consents to maximize the extent of surgical removal while minimizing the risks of permanent postoperative deficits. This results in an improvement of survival and quality of life. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s100720170029 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 3 Subjects: – SubjectFull: Gliomas Type: general – SubjectFull: Neural stimulation Type: general Titles: – TitleFull: The value of cortical stimulation applied to the surgery of malignant gliomas in language areas. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Signorelli, F. – PersonEntity: Name: NameFull: Guyotat, J. – PersonEntity: Name: NameFull: Isnard, J. – PersonEntity: Name: NameFull: Schneider, F. – PersonEntity: Name: NameFull: Mohammedi, R. – PersonEntity: Name: NameFull: Bret, P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2001 Type: published Y: 2001 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 22 – Type: issue Value: 1 Titles: – TitleFull: Neurological Sciences Type: main |
| ResultId | 1 |
