Dietary preferences of Brattleboro rats correlated with an overexpression of galanin in the hypothalamus.
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| Title: | Dietary preferences of Brattleboro rats correlated with an overexpression of galanin in the hypothalamus. |
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| Authors: | Odorizzi, Myriam (AUTHOR), Max, Jean‐Pierre (AUTHOR), Tankosic, Pierre (AUTHOR), Burlet, Claude (AUTHOR), Burlet, Arlette (AUTHOR) |
| Source: | European Journal of Neuroscience. Sep99, Vol. 11 Issue 9, p3005-3014. 10p. 1 Chart. |
| Subjects: | Galanin, Diet, Rats, Animal feeding |
| Abstract: | Abstract Galanin (GAL) is a neuropeptide cosynthesized with vasopressin (AVP) in neurons of the hypothalamo-neurohypophysial system. It increases food intake when injected into the brain and elicits an overconsumption of fat. The Brattleboro rat (DI) is genetically unable to produce AVP; the AVP-deficient-producing neurons of the hypothalamo-neurohypophysial system of DI rats are chronically stimulated and DI rats suffer from diabetes insipidus. We studied the central expression of GAL and the dietary preferences in the DI rat. GAL was overexpressed in the hypothalamus of the DI rat. GAL mRNA was higher by 1.8-fold in the supraoptic (P < 0.05) and by four-fold in the paraventricular nuclei (P < 0.001) of male and female DI rats compared with those of control Long Evans (LE) rats. However, GAL mRNA was lower in the arcuate nuclei of DI rats and equal to that of LE rats in the dorsomedian nuclei. We also measured a high preference for a lipid diet (45% of the daily consumption) when DI rats ate from a choice of the three macronutrients. Chronic infusion with deamino-8D-AVP (agonist of AVP V2 receptors) prevented the diabetes insipidus and the chronic stimulation of the hypothalamo-neurohypophysial system of the DI rats. However, the treatment did not suppress the overexpression of GAL, nor did it affect the rats’ preference for a lipid diet. We conclude that the DI rat provides a novel animal model in which a spontaneous dietary preference correlates with the overexpression of one of the hypothalamic peptides, GAL. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 5642939 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dietary preferences of Brattleboro rats correlated with an overexpression of galanin in the hypothalamus. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Odorizzi%2C+Myriam%22">Odorizzi, Myriam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Max%2C+Jean‐Pierre%22">Max, Jean‐Pierre</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tankosic%2C+Pierre%22">Tankosic, Pierre</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burlet%2C+Claude%22">Burlet, Claude</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burlet%2C+Arlette%22">Burlet, Arlette</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep99, Vol. 11 Issue 9, p3005-3014. 10p. 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Galanin%22">Galanin</searchLink><br /><searchLink fieldCode="DE" term="%22Diet%22">Diet</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+feeding%22">Animal feeding</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract Galanin (GAL) is a neuropeptide cosynthesized with vasopressin (AVP) in neurons of the hypothalamo-neurohypophysial system. It increases food intake when injected into the brain and elicits an overconsumption of fat. The Brattleboro rat (DI) is genetically unable to produce AVP; the AVP-deficient-producing neurons of the hypothalamo-neurohypophysial system of DI rats are chronically stimulated and DI rats suffer from diabetes insipidus. We studied the central expression of GAL and the dietary preferences in the DI rat. GAL was overexpressed in the hypothalamus of the DI rat. GAL mRNA was higher by 1.8-fold in the supraoptic (P < 0.05) and by four-fold in the paraventricular nuclei (P < 0.001) of male and female DI rats compared with those of control Long Evans (LE) rats. However, GAL mRNA was lower in the arcuate nuclei of DI rats and equal to that of LE rats in the dorsomedian nuclei. We also measured a high preference for a lipid diet (45% of the daily consumption) when DI rats ate from a choice of the three macronutrients. Chronic infusion with deamino-8D-AVP (agonist of AVP V2 receptors) prevented the diabetes insipidus and the chronic stimulation of the hypothalamo-neurohypophysial system of the DI rats. However, the treatment did not suppress the overexpression of GAL, nor did it affect the rats’ preference for a lipid diet. We conclude that the DI rat provides a novel animal model in which a spontaneous dietary preference correlates with the overexpression of one of the hypothalamic peptides, GAL. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=5642939 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1046/j.1460-9568.1999.00722.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 3005 Subjects: – SubjectFull: Galanin Type: general – SubjectFull: Diet Type: general – SubjectFull: Rats Type: general – SubjectFull: Animal feeding Type: general Titles: – TitleFull: Dietary preferences of Brattleboro rats correlated with an overexpression of galanin in the hypothalamus. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Odorizzi, Myriam – PersonEntity: Name: NameFull: Max, Jean‐Pierre – PersonEntity: Name: NameFull: Tankosic, Pierre – PersonEntity: Name: NameFull: Burlet, Claude – PersonEntity: Name: NameFull: Burlet, Arlette IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep99 Type: published Y: 1999 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 11 – Type: issue Value: 9 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
