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Anorexia nervosa trios: behavioral profiles of individuals with anorexia nervosa and their parents.

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Title: Anorexia nervosa trios: behavioral profiles of individuals with anorexia nervosa and their parents.
Authors: Jacobs, M. J., Roesch, S., Wonderlich, S. A., Crosby, R., Thornton, L., Wilfley, D. E., Berrettini, W. H., Brandt, H., Crawford, S., Fichter, M. M., Halmi, K. A., Johnson, C., Kaplan, A. S., LaVia, M., Mitchell, J. E., Rotondo, A., Strober, M., Woodside, D. B., Kaye, W. H., Bulik, C. M.
Source: Psychological Medicine. Mar2009, Vol. 39 Issue 3, p451-461. 11p. 5 Charts.
Subjects: Anorexia nervosa, Eating disorders, Temperament, Anxiety, Genetic research
Abstract: BackgroundAnorexia nervosa (AN) is associated with behavioral traits that predate the onset of AN and persist after recovery. We identified patterns of behavioral traits in AN trios (proband plus two biological parents).MethodA total of 433 complete trios were collected in the Price Foundation Genetic Study of AN using standardized instruments for eating disorder (ED) symptoms, anxiety, perfectionism, and temperament. We used latent profile analysis and ANOVA to identify and validate patterns of behavioral traits.ResultsWe distinguished three classes with medium to large effect sizes by mothers' and probands' drive for thinness, body dissatisfaction, perfectionism, neuroticism, trait anxiety, and harm avoidance. Fathers did not differ significantly across classes. Classes were distinguished by degree of symptomatology rather than qualitative differences. Class 1 (~33%) comprised low symptom probands and mothers with scores in the healthy range. Class 2 (~43%) included probands with marked elevations in drive for thinness, body dissatisfaction, neuroticism, trait anxiety, and harm avoidance and mothers with mild anxious/perfectionistic traits. Class 3 (~24%) included probands and mothers with elevations on ED and anxious/perfectionistic traits. Mother–daughter symptom severity was related in classes 1 and 3 only. Trio profiles did not differ significantly by proband clinical status or subtype.ConclusionsA key finding is the importance of mother and daughter traits in the identification of temperament and personality patterns in families affected by AN. Mother–daughter pairs with severe ED and anxious/perfectionistic traits may represent a more homogeneous and familial variant of AN that could be of value in genetic studies. [ABSTRACT FROM PUBLISHER]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Anorexia nervosa trios: behavioral profiles of individuals with anorexia nervosa and their parents.
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  Data: <searchLink fieldCode="AR" term="%22Jacobs%2C+M%2E+J%2E%22">Jacobs, M. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Roesch%2C+S%2E%22">Roesch, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Wonderlich%2C+S%2E+A%2E%22">Wonderlich, S. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Crosby%2C+R%2E%22">Crosby, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Thornton%2C+L%2E%22">Thornton, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Wilfley%2C+D%2E+E%2E%22">Wilfley, D. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Berrettini%2C+W%2E+H%2E%22">Berrettini, W. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Brandt%2C+H%2E%22">Brandt, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Crawford%2C+S%2E%22">Crawford, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Fichter%2C+M%2E+M%2E%22">Fichter, M. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Halmi%2C+K%2E+A%2E%22">Halmi, K. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Johnson%2C+C%2E%22">Johnson, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Kaplan%2C+A%2E+S%2E%22">Kaplan, A. S.</searchLink><br /><searchLink fieldCode="AR" term="%22LaVia%2C+M%2E%22">LaVia, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Mitchell%2C+J%2E+E%2E%22">Mitchell, J. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Rotondo%2C+A%2E%22">Rotondo, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Strober%2C+M%2E%22">Strober, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Woodside%2C+D%2E+B%2E%22">Woodside, D. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Kaye%2C+W%2E+H%2E%22">Kaye, W. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Bulik%2C+C%2E+M%2E%22">Bulik, C. M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Mar2009, Vol. 39 Issue 3, p451-461. 11p. 5 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Anorexia+nervosa%22">Anorexia nervosa</searchLink><br /><searchLink fieldCode="DE" term="%22Eating+disorders%22">Eating disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Temperament%22">Temperament</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+research%22">Genetic research</searchLink>
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  Data: BackgroundAnorexia nervosa (AN) is associated with behavioral traits that predate the onset of AN and persist after recovery. We identified patterns of behavioral traits in AN trios (proband plus two biological parents).MethodA total of 433 complete trios were collected in the Price Foundation Genetic Study of AN using standardized instruments for eating disorder (ED) symptoms, anxiety, perfectionism, and temperament. We used latent profile analysis and ANOVA to identify and validate patterns of behavioral traits.ResultsWe distinguished three classes with medium to large effect sizes by mothers' and probands' drive for thinness, body dissatisfaction, perfectionism, neuroticism, trait anxiety, and harm avoidance. Fathers did not differ significantly across classes. Classes were distinguished by degree of symptomatology rather than qualitative differences. Class 1 (~33%) comprised low symptom probands and mothers with scores in the healthy range. Class 2 (~43%) included probands with marked elevations in drive for thinness, body dissatisfaction, neuroticism, trait anxiety, and harm avoidance and mothers with mild anxious/perfectionistic traits. Class 3 (~24%) included probands and mothers with elevations on ED and anxious/perfectionistic traits. Mother–daughter symptom severity was related in classes 1 and 3 only. Trio profiles did not differ significantly by proband clinical status or subtype.ConclusionsA key finding is the importance of mother and daughter traits in the identification of temperament and personality patterns in families affected by AN. Mother–daughter pairs with severe ED and anxious/perfectionistic traits may represent a more homogeneous and familial variant of AN that could be of value in genetic studies. [ABSTRACT FROM PUBLISHER]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=56668964
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