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Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes.

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Title: Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes.
Authors: They-They, T. P., Nadifi, S., Rafai, M. A., Battas, O., Slassi, I.
Source: Acta Neurologica Scandinavica. Feb2011, Vol. 123 Issue 2, p105-110. 6p.
Subjects: Genetic polymorphisms, Arterial diseases, Cerebrovascular disease risk factors, Case-control method, Gene frequency
Geographic Terms: Casablanca (Morocco), Morocco
Abstract: They-They TP, Nadifi S, Rafai MA, Battas O, Slassi I. Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes. Acta Neurol Scand: 2011: 123: 105-110. © 2010 John Wiley & Sons A/S. The role for the methylenetetrahydrofolate reductase C677T gene variants in the risk of ischemic stroke is controversial. This first case-control study including 91 cases affected by ischemic stroke and 182 controls matched for age, sex, and same area was conducted in Casablanca, Morocco. Allele and genotype frequency were characterized by using PCR followed by HinfI enzymatic digestion. We found no statistic association of T allele carriers genetic factors with stroke; odds ratio, 1.1; 95% confidence interval (CI), 0.59-2.04, P = 0.303. The results shown significant association of T allele carriers genetic factors with atherothrombotic subtype stroke ( n = 42); odds ratio, 2.1; 95% CI: 1.17-3.8; P = 0.012, and adjusted odds ratio of 6.5; 95% CI: 1.86-23.1, P = 0.003, for TT genotype variant compared with CC wild genotype. We suggested that MTHFR C677T variant may be a determinant of atherothrombotic event of ischemic stroke in Morocco. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: They-They TP, Nadifi S, Rafai MA, Battas O, Slassi I. Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes. Acta Neurol Scand: 2011: 123: 105-110. © 2010 John Wiley & Sons A/S. The role for the methylenetetrahydrofolate reductase C677T gene variants in the risk of ischemic stroke is controversial. This first case-control study including 91 cases affected by ischemic stroke and 182 controls matched for age, sex, and same area was conducted in Casablanca, Morocco. Allele and genotype frequency were characterized by using PCR followed by HinfI enzymatic digestion. We found no statistic association of T allele carriers genetic factors with stroke; odds ratio, 1.1; 95% confidence interval (CI), 0.59-2.04, P = 0.303. The results shown significant association of T allele carriers genetic factors with atherothrombotic subtype stroke ( n = 42); odds ratio, 2.1; 95% CI: 1.17-3.8; P = 0.012, and adjusted odds ratio of 6.5; 95% CI: 1.86-23.1, P = 0.003, for TT genotype variant compared with CC wild genotype. We suggested that MTHFR C677T variant may be a determinant of atherothrombotic event of ischemic stroke in Morocco. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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