SNP Variations in the 7q33 Region Containing DGKI are Associated with Dyslexia in the Finnish and German Populations.
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| Title: | SNP Variations in the 7q33 Region Containing DGKI are Associated with Dyslexia in the Finnish and German Populations. |
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| Authors: | Matsson, Hans, Tammimies, Kristiina, Zucchelli, Marco, Anthoni, Heidi, Onkamo, Päivi, Nopola-Hemmi, Jaana, Lyytinen, Heikki, Leppanen, Paavo H. T., Neuhoff, Nina, Warnke, Andreas, Schulte-Körne, Gert, Schumacher, Johannes, Nöthen, Markus M., Kere, Juha, Peyrard-Janvid, Myriam |
| Source: | Behavior Genetics. Jan2011, Vol. 41 Issue 1, p134-140. 7p. 1 Diagram, 1 Chart, 1 Graph. |
| Subjects: | Dyslexia, Genes, Learning disability genetics, Linkage (Genetics), Reading disability, Developmental disabilities |
| Abstract: | Four genes, DYX1C1, ROBO1, DCDC2 and KIAA0319 have been studied both genetically and functionally as candidate genes for developmental dyslexia, a common learning disability in children. The identification of novel genes is crucial to better understand the molecular pathways affected in dyslectic individuals. Here, we report results from a fine-mapping approach involving linkage and association analysis in Finnish and German dyslexic cohorts. We restrict a candidate region to 0.3 Mb on chromosome 7q33. This region harbours the gene diacylglycerol kinase, iota ( DGKI) which contains overlapping haplotypes associated with dyslexia in both Finnish and German sample sets. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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