Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
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| Title: | Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. |
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| Authors: | Reilly, Muredach P., Mingyao Li, Jing He, Ferguson, Jane F., Stylianou, Ioannis M., Mehta, Nehal N., Burnett, Mary Susan, Devaney, Joseph M., Knouff, Christopher W., Thompson, John R., Horne, Benjamin D., Stewart, Alexandre F. R., Assimes, Themistocles L., Wild, Philipp S., Allayee, Hooman, Nitschke, Patrick Linsel, Patel, Riyaz S., Martinelli, Nicola, Girelli, Domenico, Quyyumi, Arshed A. |
| Source: | Lancet. 1/29/2011, Vol. 377 Issue 9763, p383-392. 10p. |
| Subjects: | Coronary disease, Atherosclerosis, Myocardial infarction, Genetics, Angiography |
| Abstract: | The article discusses a study which examined whether genetic factors contribute to the development of coronary atherosclerosis or to myocardial infarction in existing coronary atherosclerosis. Individuals affected with the disorder were compared to those who did not to identify loci that predispose to angiographic coronary artery disease (CAD). Findings showed that a novel locus, ADAMTS7, was found in the comparison of patients with angiographic CAD versus controls. |
| Database: | Psychology and Behavioral Sciences Collection |
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