Drug discovery: A question of library design.
Saved in:
| Title: | Drug discovery: A question of library design. |
|---|---|
| Authors: | Hajduk, Philip J., Galloway, Warren R. J. D., Spring, David R. |
| Source: | Nature. 2/3/2011, Vol. 470 Issue 7332, p42-43. 2p. 1 Color Photograph, 1 Diagram. |
| Subjects: | Drug design, Experimental design, Molecular weights, Bioactive compounds, Experiments |
| Abstract: | The article offers the authors' insights on the benefits and defects of fragment-based screening (FBS) and diversity-oriented synthesis (DOS) methods in creating libraries of compounds for drug discovery. It says that FBS design offers varied libraries and improved use of synthetic resources. It tells that DOS libraries develop diverse molecules whose molecular weights are proximate to the masses of drug-like compounds. It adds that unlike DOS, FBS would not offer non-traditional target hints. |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 57775613 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Drug discovery: A question of library design. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hajduk%2C+Philip+J%2E%22">Hajduk, Philip J.</searchLink><br /><searchLink fieldCode="AR" term="%22Galloway%2C+Warren+R%2E+J%2E+D%2E%22">Galloway, Warren R. J. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Spring%2C+David+R%2E%22">Spring, David R.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 2/3/2011, Vol. 470 Issue 7332, p42-43. 2p. 1 Color Photograph, 1 Diagram. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Drug+design%22">Drug design</searchLink><br /><searchLink fieldCode="DE" term="%22Experimental+design%22">Experimental design</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+weights%22">Molecular weights</searchLink><br /><searchLink fieldCode="DE" term="%22Bioactive+compounds%22">Bioactive compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Experiments%22">Experiments</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The article offers the authors' insights on the benefits and defects of fragment-based screening (FBS) and diversity-oriented synthesis (DOS) methods in creating libraries of compounds for drug discovery. It says that FBS design offers varied libraries and improved use of synthetic resources. It tells that DOS libraries develop diverse molecules whose molecular weights are proximate to the masses of drug-like compounds. It adds that unlike DOS, FBS would not offer non-traditional target hints. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=57775613 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/470042a Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 2 StartPage: 42 Subjects: – SubjectFull: Drug design Type: general – SubjectFull: Experimental design Type: general – SubjectFull: Molecular weights Type: general – SubjectFull: Bioactive compounds Type: general – SubjectFull: Experiments Type: general Titles: – TitleFull: Drug discovery: A question of library design. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hajduk, Philip J. – PersonEntity: Name: NameFull: Galloway, Warren R. J. D. – PersonEntity: Name: NameFull: Spring, David R. IsPartOfRelationships: – BibEntity: Dates: – D: 03 M: 02 Text: 2/3/2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 470 – Type: issue Value: 7332 Titles: – TitleFull: Nature Type: main |
| ResultId | 1 |
