Bibliographic Details
| Title: |
Botulinum toxin improves dysphagia associated with multiple sclerosis. |
| Authors: |
Restivo, D. A., Marchese-Ragona, R., Patti, F., Solaro, C., Maimone, D., Zappalá, G., Pavone, A. |
| Source: |
European Journal of Neurology. Mar2011, Vol. 18 Issue 3, p486-490. 5p. 1 Chart, 3 Graphs. |
| Subjects: |
Neurophysiology, Botulinum toxin, Deglutition disorders, Multiple sclerosis, Videofluoroscopy, Pharyngoesophageal sphincter, Deglutition |
| Abstract: |
To evaluate the efficacy of botulinum neurotoxin type A (BoNT/A) for severe oro-pharyngeal dysphagia associated with multiple sclerosis (MS). BoNT/A was injected percutaneously into the hyperactive cricopharyngeal muscle of 14 dysphagic MS patients under electromyographic control. Patients were evaluated by videofluoroscopic and electromyographic examinations and by the Penetration/Aspiration Scale (PAS), at week 1, 4, 12, 16, 18, and 24 after BoNT/A injection. All patients showed a significant improvement in all the swallowing outcome measures. No specific treatment for oro-pharyngeal dysphagia related to MS has been described to date. Our preliminary findings suggest a potential benefit from BoNT/A treatment in MS patients with dysphagia associated with upper esophageal sphincter hyperactivity. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
