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Botulinum toxin improves dysphagia associated with multiple sclerosis.

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Title: Botulinum toxin improves dysphagia associated with multiple sclerosis.
Authors: Restivo, D. A., Marchese-Ragona, R., Patti, F., Solaro, C., Maimone, D., Zappalá, G., Pavone, A.
Source: European Journal of Neurology. Mar2011, Vol. 18 Issue 3, p486-490. 5p. 1 Chart, 3 Graphs.
Subjects: Neurophysiology, Botulinum toxin, Deglutition disorders, Multiple sclerosis, Videofluoroscopy, Pharyngoesophageal sphincter, Deglutition
Abstract: To evaluate the efficacy of botulinum neurotoxin type A (BoNT/A) for severe oro-pharyngeal dysphagia associated with multiple sclerosis (MS). BoNT/A was injected percutaneously into the hyperactive cricopharyngeal muscle of 14 dysphagic MS patients under electromyographic control. Patients were evaluated by videofluoroscopic and electromyographic examinations and by the Penetration/Aspiration Scale (PAS), at week 1, 4, 12, 16, 18, and 24 after BoNT/A injection. All patients showed a significant improvement in all the swallowing outcome measures. No specific treatment for oro-pharyngeal dysphagia related to MS has been described to date. Our preliminary findings suggest a potential benefit from BoNT/A treatment in MS patients with dysphagia associated with upper esophageal sphincter hyperactivity. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Botulinum toxin improves dysphagia associated with multiple sclerosis.
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  Data: <searchLink fieldCode="AR" term="%22Restivo%2C+D%2E+A%2E%22">Restivo, D. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Marchese-Ragona%2C+R%2E%22">Marchese-Ragona, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Patti%2C+F%2E%22">Patti, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Solaro%2C+C%2E%22">Solaro, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Maimone%2C+D%2E%22">Maimone, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Zappalá%2C+G%2E%22">Zappalá, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Pavone%2C+A%2E%22">Pavone, A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Mar2011, Vol. 18 Issue 3, p486-490. 5p. 1 Chart, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Neurophysiology%22">Neurophysiology</searchLink><br /><searchLink fieldCode="DE" term="%22Botulinum+toxin%22">Botulinum toxin</searchLink><br /><searchLink fieldCode="DE" term="%22Deglutition+disorders%22">Deglutition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Videofluoroscopy%22">Videofluoroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Pharyngoesophageal+sphincter%22">Pharyngoesophageal sphincter</searchLink><br /><searchLink fieldCode="DE" term="%22Deglutition%22">Deglutition</searchLink>
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  Data: To evaluate the efficacy of botulinum neurotoxin type A (BoNT/A) for severe oro-pharyngeal dysphagia associated with multiple sclerosis (MS). BoNT/A was injected percutaneously into the hyperactive cricopharyngeal muscle of 14 dysphagic MS patients under electromyographic control. Patients were evaluated by videofluoroscopic and electromyographic examinations and by the Penetration/Aspiration Scale (PAS), at week 1, 4, 12, 16, 18, and 24 after BoNT/A injection. All patients showed a significant improvement in all the swallowing outcome measures. No specific treatment for oro-pharyngeal dysphagia related to MS has been described to date. Our preliminary findings suggest a potential benefit from BoNT/A treatment in MS patients with dysphagia associated with upper esophageal sphincter hyperactivity. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1468-1331.2010.03189.x
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        Text: English
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      – SubjectFull: Botulinum toxin
        Type: general
      – SubjectFull: Deglutition disorders
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      – SubjectFull: Multiple sclerosis
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      – SubjectFull: Videofluoroscopy
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      – SubjectFull: Pharyngoesophageal sphincter
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      – TitleFull: Botulinum toxin improves dysphagia associated with multiple sclerosis.
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              Text: Mar2011
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