Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.
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| Title: | Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. |
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| Authors: | Lafourcade, Mathieu, Larrieu, Thomas, Mato, Susana, Duffaud, Anais, Sepers, Marja, Matias, Isabelle, De Smedt-Peyrusse, Veronique, Labrousse, Virginie F., Bretillon, Lionel, Matute, Carlos, Rodríguez-Puertas, Rafael, Layé, Sophie, Manzoni, Olivier J. |
| Source: | Nature Neuroscience. Mar2011, Vol. 14 Issue 3, p345-350. 6p. 5 Graphs. |
| Subjects: | Omega-3 fatty acids, Obesity, Malnutrition, Neurobehavioral disorders, Prefrontal cortex, Linoleic acid |
| Abstract: | The corollaries of the obesity epidemic that plagues developed societies are malnutrition and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to neuropsychiatric diseases, but the underlying synaptic alterations are mostly unknown. We found that lifelong n-3 PUFAs dietary insufficiency specifically ablates long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. In n-3-deficient mice, presynaptic cannabinoid CB1 receptors (CB1Rs) normally responding to endocannabinoids were uncoupled from their effector Gi/o proteins. Finally, the dietary-induced reduction of CB1R functions in mood-controlling structures was associated with impaired emotional behavior. These findings identify a plausible synaptic substrate for the behavioral alterations caused by the n-3 PUFAs deficiency that is often observed in western diets. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 58638128 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nn.2736 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 345 Subjects: – SubjectFull: Omega-3 fatty acids Type: general – SubjectFull: Obesity Type: general – SubjectFull: Malnutrition Type: general – SubjectFull: Neurobehavioral disorders Type: general – SubjectFull: Prefrontal cortex Type: general – SubjectFull: Linoleic acid Type: general Titles: – TitleFull: Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lafourcade, Mathieu – PersonEntity: Name: NameFull: Larrieu, Thomas – PersonEntity: Name: NameFull: Mato, Susana – PersonEntity: Name: NameFull: Duffaud, Anais – PersonEntity: Name: NameFull: Sepers, Marja – PersonEntity: Name: NameFull: Matias, Isabelle – PersonEntity: Name: NameFull: De Smedt-Peyrusse, Veronique – PersonEntity: Name: NameFull: Labrousse, Virginie F. – PersonEntity: Name: NameFull: Bretillon, Lionel – PersonEntity: Name: NameFull: Matute, Carlos – PersonEntity: Name: NameFull: Rodríguez-Puertas, Rafael – PersonEntity: Name: NameFull: Layé, Sophie – PersonEntity: Name: NameFull: Manzoni, Olivier J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 10976256 Numbering: – Type: volume Value: 14 – Type: issue Value: 3 Titles: – TitleFull: Nature Neuroscience Type: main |
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