View in EDS HTML Full Text PDF Full Text

Genetics of the association between intelligence and nicotine dependence: a study of male Swedish twins.

Saved in:
Bibliographic Details
Title: Genetics of the association between intelligence and nicotine dependence: a study of male Swedish twins.
Authors: Modig, Karin (AUTHOR), Silventoinen, Karri (AUTHOR), Tynelius, Per (AUTHOR), Kaprio, Jaakko (AUTHOR), Rasmussen, Finn (AUTHOR)
Source: Addiction. May2011, Vol. 106 Issue 5, p995-1002. 8p. 5 Charts.
Subjects: Intellect & genetics, Smoking, Computer software, Confidence intervals, Drug addiction, Classification of mental disorders, Regression analysis, Research funding, Smokeless tobacco, Twins, Phenotypes, Data analysis, Socioeconomic factors, Educational attainment, Structural equation modeling, Genetics
Geographic Terms: Sweden
Abstract: Previous studies have found inverse associations between intelligence quotient (IQ) and cigarette smoking, but the causal pathways linking IQ with smoking status and nicotine dependence (ND) are not well understood. The aim of this study was to explore the associations between IQ and ND using a genetically informative twin design to detect whether any association is because of shared genetic or environmental factors. A population-based twin cohort with IQ measured in adolescence and ND later in life, analysed by classical twin modeling based on linear structural equations. Swedish national registry data. A total of 5040 male twins born 1951-84. IQ was measured at military conscription at a mean age of 18 years. ND was self-reported at the ages of 22-57 years using the Fagerström Test for ND scale (FTND). Both cigarette smoking and Swedish snus use were analysed. Both IQ and ND showed moderate heritability (0.58 and 0.39, respectively). The heritability of ND was similar for cigarette smoking and snus use. The phenotypic correlation between IQ and ND was weak: −0.11 (−0.16, −0.06) for total ND. Bivariate analysis revealed that this correlation was mainly because of genetic factors, but still the genetic correlation between IQ and ND from cigarette smoking was only −0.24. Nicotine dependence, as measured by the Fagerström Test for Nicotine Dependence, shows moderate heritability in both smokers and snus users but is only weakly associated with intelligence quotient; common genetic factors underlying nicotine dependence and intelligence quotient probably account for little of the observed association between smoking and intelligence quotient. [ABSTRACT FROM AUTHOR]
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 59883845
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Genetics of the association between intelligence and nicotine dependence: a study of male Swedish twins.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Modig%2C+Karin%22">Modig, Karin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Silventoinen%2C+Karri%22">Silventoinen, Karri</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tynelius%2C+Per%22">Tynelius, Per</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kaprio%2C+Jaakko%22">Kaprio, Jaakko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rasmussen%2C+Finn%22">Rasmussen, Finn</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Addiction%22">Addiction</searchLink>. May2011, Vol. 106 Issue 5, p995-1002. 8p. 5 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Intellect+%26+genetics%22">Intellect & genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Smoking%22">Smoking</searchLink><br /><searchLink fieldCode="DE" term="%22Computer+software%22">Computer software</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+addiction%22">Drug addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Classification+of+mental+disorders%22">Classification of mental disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Smokeless+tobacco%22">Smokeless tobacco</searchLink><br /><searchLink fieldCode="DE" term="%22Twins%22">Twins</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Socioeconomic+factors%22">Socioeconomic factors</searchLink><br /><searchLink fieldCode="DE" term="%22Educational+attainment%22">Educational attainment</searchLink><br /><searchLink fieldCode="DE" term="%22Structural+equation+modeling%22">Structural equation modeling</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Sweden%22">Sweden</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Previous studies have found inverse associations between intelligence quotient (IQ) and cigarette smoking, but the causal pathways linking IQ with smoking status and nicotine dependence (ND) are not well understood. The aim of this study was to explore the associations between IQ and ND using a genetically informative twin design to detect whether any association is because of shared genetic or environmental factors. A population-based twin cohort with IQ measured in adolescence and ND later in life, analysed by classical twin modeling based on linear structural equations. Swedish national registry data. A total of 5040 male twins born 1951-84. IQ was measured at military conscription at a mean age of 18 years. ND was self-reported at the ages of 22-57 years using the Fagerström Test for ND scale (FTND). Both cigarette smoking and Swedish snus use were analysed. Both IQ and ND showed moderate heritability (0.58 and 0.39, respectively). The heritability of ND was similar for cigarette smoking and snus use. The phenotypic correlation between IQ and ND was weak: −0.11 (−0.16, −0.06) for total ND. Bivariate analysis revealed that this correlation was mainly because of genetic factors, but still the genetic correlation between IQ and ND from cigarette smoking was only −0.24. Nicotine dependence, as measured by the Fagerström Test for Nicotine Dependence, shows moderate heritability in both smokers and snus users but is only weakly associated with intelligence quotient; common genetic factors underlying nicotine dependence and intelligence quotient probably account for little of the observed association between smoking and intelligence quotient. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=59883845
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1360-0443.2011.03384.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 995
    Subjects:
      – SubjectFull: Intellect & genetics
        Type: general
      – SubjectFull: Smoking
        Type: general
      – SubjectFull: Computer software
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Drug addiction
        Type: general
      – SubjectFull: Classification of mental disorders
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Smokeless tobacco
        Type: general
      – SubjectFull: Twins
        Type: general
      – SubjectFull: Phenotypes
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Socioeconomic factors
        Type: general
      – SubjectFull: Educational attainment
        Type: general
      – SubjectFull: Structural equation modeling
        Type: general
      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Sweden
        Type: general
    Titles:
      – TitleFull: Genetics of the association between intelligence and nicotine dependence: a study of male Swedish twins.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Modig, Karin
      – PersonEntity:
          Name:
            NameFull: Silventoinen, Karri
      – PersonEntity:
          Name:
            NameFull: Tynelius, Per
      – PersonEntity:
          Name:
            NameFull: Kaprio, Jaakko
      – PersonEntity:
          Name:
            NameFull: Rasmussen, Finn
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2011
              Type: published
              Y: 2011
          Identifiers:
            – Type: issn-print
              Value: 09652140
          Numbering:
            – Type: volume
              Value: 106
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: Addiction
              Type: main
ResultId 1