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Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory.

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Title: Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory.
Authors: Zanto, Theodore P., Rubens, Michael T., Thangavel, Arul, Gazzaley, Adam
Source: Nature Neuroscience. May2011, Vol. 14 Issue 5, p656-661. 6p. 2 Color Photographs, 4 Graphs.
Subjects: Prefrontal cortex, Selectivity (Psychology), Frontal lobe, Short-term memory, Recollection (Psychology)
Abstract: Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magnetic resonance imaging to guide repetitive transcranial magnetic stimulation with electroencephalographic recordings in humans, we perturbed PFC function at the inferior frontal junction in participants before they performed a selective-attention, delayed-recognition task. This resulted in diminished top-down modulation of activity in posterior cortex during early encoding stages, which predicted a subsequent decrement in working memory accuracy. Participants with stronger fronto-posterior functional connectivity displayed greater disruptive effects. Our data further suggests that broad alpha-band (7-14 Hz) phase coherence subserved this long-distance top-down modulation. These results suggest that top-down modulation mediated by the prefrontal cortex is a causal link between early attentional processes and subsequent memory performance. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Causal role of the prefrontal cortex in top-down modulation of visual processing and working memory.
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  Data: <searchLink fieldCode="AR" term="%22Zanto%2C+Theodore+P%2E%22">Zanto, Theodore P.</searchLink><br /><searchLink fieldCode="AR" term="%22Rubens%2C+Michael+T%2E%22">Rubens, Michael T.</searchLink><br /><searchLink fieldCode="AR" term="%22Thangavel%2C+Arul%22">Thangavel, Arul</searchLink><br /><searchLink fieldCode="AR" term="%22Gazzaley%2C+Adam%22">Gazzaley, Adam</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. May2011, Vol. 14 Issue 5, p656-661. 6p. 2 Color Photographs, 4 Graphs.
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  Data: Selective attention filters information to limit what is encoded and maintained in working memory. Although the prefrontal cortex (PFC) is central to both selective attention and working memory, the underlying neural processes that link these cognitive abilities remain elusive. Using functional magnetic resonance imaging to guide repetitive transcranial magnetic stimulation with electroencephalographic recordings in humans, we perturbed PFC function at the inferior frontal junction in participants before they performed a selective-attention, delayed-recognition task. This resulted in diminished top-down modulation of activity in posterior cortex during early encoding stages, which predicted a subsequent decrement in working memory accuracy. Participants with stronger fronto-posterior functional connectivity displayed greater disruptive effects. Our data further suggests that broad alpha-band (7-14 Hz) phase coherence subserved this long-distance top-down modulation. These results suggest that top-down modulation mediated by the prefrontal cortex is a causal link between early attentional processes and subsequent memory performance. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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