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Impact of acute hypobaric hypoxia on blood flow distribution in brain.

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Title: Impact of acute hypobaric hypoxia on blood flow distribution in brain.
Authors: Pagani, M., Salmaso, D., Sidiras, G. Gr., Jonsson, C., Jacobsson, H., Larsson, S. A., Lind, F.
Source: Acta Physiologica. Jun2011, Vol. 202 Issue 2, p203-209. 7p. 3 Color Photographs, 1 Graph.
Subjects: Hypoxemia, Cerebral circulation, Single-photon emission computed tomography, Limbic system, Frontal lobe
Abstract: Acute hypobaric hypoxia is well known to alter brain circulation and to cause neuropsychological impairment. However, very few studies have examined the regional changes occurring in the brain during acute exposure to extreme hypoxic conditions. Regional cerebral blood flow (rCBF) response to hypoxia was investigated in six healthy subjects exposed to either normobaric normoxia or hypobaric hypoxia with ambient pressure/inspired oxygen pressure of 101/21 kPa and 50/11 kPa respectively. After 40 min at the desired pressure they were injected Tc-HMPAO and subsequently underwent single photon emission computed tomography. Regional cerebral blood flow distribution changes in the whole brain were assessed by Statistical Parametric Mapping, a well established voxel-based analysis method. Hypobaric hypoxia increased rCBF distribution in sensorymotor and prefrontal cortices and in central structures. PCO correlated positively and SatO negatively with rCBF in several temporal, parahippocampal, parietal and central structures. These findings underscore the specific sensitivity of the frontal lobe to acute hypobaric hypoxia and of limbic and central structures to blood gas changes emphasizing the involvement of these brain areas in acute hypoxia. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Impact of acute hypobaric hypoxia on blood flow distribution in brain.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Jun2011, Vol. 202 Issue 2, p203-209. 7p. 3 Color Photographs, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Hypoxemia%22">Hypoxemia</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+circulation%22">Cerebral circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Single-photon+emission+computed+tomography%22">Single-photon emission computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Limbic+system%22">Limbic system</searchLink><br /><searchLink fieldCode="DE" term="%22Frontal+lobe%22">Frontal lobe</searchLink>
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  Data: Acute hypobaric hypoxia is well known to alter brain circulation and to cause neuropsychological impairment. However, very few studies have examined the regional changes occurring in the brain during acute exposure to extreme hypoxic conditions. Regional cerebral blood flow (rCBF) response to hypoxia was investigated in six healthy subjects exposed to either normobaric normoxia or hypobaric hypoxia with ambient pressure/inspired oxygen pressure of 101/21 kPa and 50/11 kPa respectively. After 40 min at the desired pressure they were injected Tc-HMPAO and subsequently underwent single photon emission computed tomography. Regional cerebral blood flow distribution changes in the whole brain were assessed by Statistical Parametric Mapping, a well established voxel-based analysis method. Hypobaric hypoxia increased rCBF distribution in sensorymotor and prefrontal cortices and in central structures. PCO correlated positively and SatO negatively with rCBF in several temporal, parahippocampal, parietal and central structures. These findings underscore the specific sensitivity of the frontal lobe to acute hypobaric hypoxia and of limbic and central structures to blood gas changes emphasizing the involvement of these brain areas in acute hypoxia. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1748-1716.2011.02264.x
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              Text: Jun2011
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