Functional magnetic resonance imaging of a parametric working memory task in schizophrenia: relationship with performance and effects of antipsychotic treatment.
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| Title: | Functional magnetic resonance imaging of a parametric working memory task in schizophrenia: relationship with performance and effects of antipsychotic treatment. |
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| Authors: | Ettinger, Ulrich, Williams, Steven, Fannon, Dominic, Premkumar, Preethi, Kuipers, Elizabeth, Möller, Hans-Jürgen, Kumari, Veena |
| Source: | Psychopharmacology. Jul2011, Vol. 216 Issue 1, p17-27. 11p. 1 Color Photograph, 3 Charts, 3 Graphs. |
| Subjects: | Magnetic resonance imaging of the brain, Short-term memory, Schizophrenia, Antipsychotic agents, Brain imaging, Oxygen in the body, Prefrontal cortex, Pathological psychology |
| Abstract: | Rationale: Working memory dysfunction is frequently observed in schizophrenia. The neural mechanisms underlying this dysfunction remain unclear, with functional neuroimaging studies reporting increased, decreased or unchanged activation compared to controls. Objectives: We investigated the neural correlates of spatial working memory in schizophrenia with particular consideration of effects of antipsychotic treatment and relation to performance levels in the patient group. Method: We used functional magnetic resonance imaging and studied the blood-oxygen-level-dependent (BOLD) response of 45 schizophrenia outpatients and 19 healthy controls during a parametric spatial n-back task. Results: Performance in both groups deteriorated with increasing memory load (0-back, 1-back, 2-back), but the two groups did not significantly differ in performance overall or as a function of load. Patients produced stronger BOLD signal in occipital and lateral prefrontal cortex during task performance than controls. This difference increased with increasing working memory load in the prefrontal areas. We also found that in patients with good task performance, the BOLD response in left prefrontal cortex showed a stronger parametric increase with working memory load than in patients with poor performance. Second-generation antipsychotics were independently associated with left prefrontal BOLD increase in response to working memory load, whereas first-generation antipsychotics were associated with BOLD decrease with increasing load in this area. Conclusions: Together, these findings suggest that in schizophrenia patients, normal working memory task performance may be achieved through compensatory neural activity, especially in well-performing patients and in those treated with second-generation antipsychotics. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 61142067 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Functional magnetic resonance imaging of a parametric working memory task in schizophrenia: relationship with performance and effects of antipsychotic treatment. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ettinger%2C+Ulrich%22">Ettinger, Ulrich</searchLink><br /><searchLink fieldCode="AR" term="%22Williams%2C+Steven%22">Williams, Steven</searchLink><br /><searchLink fieldCode="AR" term="%22Fannon%2C+Dominic%22">Fannon, Dominic</searchLink><br /><searchLink fieldCode="AR" term="%22Premkumar%2C+Preethi%22">Premkumar, Preethi</searchLink><br /><searchLink fieldCode="AR" term="%22Kuipers%2C+Elizabeth%22">Kuipers, Elizabeth</searchLink><br /><searchLink fieldCode="AR" term="%22Möller%2C+Hans-Jürgen%22">Möller, Hans-Jürgen</searchLink><br /><searchLink fieldCode="AR" term="%22Kumari%2C+Veena%22">Kumari, Veena</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jul2011, Vol. 216 Issue 1, p17-27. 11p. 1 Color Photograph, 3 Charts, 3 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging+of+the+brain%22">Magnetic resonance imaging of the brain</searchLink><br /><searchLink fieldCode="DE" term="%22Short-term+memory%22">Short-term memory</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Oxygen+in+the+body%22">Oxygen in the body</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Working memory dysfunction is frequently observed in schizophrenia. The neural mechanisms underlying this dysfunction remain unclear, with functional neuroimaging studies reporting increased, decreased or unchanged activation compared to controls. Objectives: We investigated the neural correlates of spatial working memory in schizophrenia with particular consideration of effects of antipsychotic treatment and relation to performance levels in the patient group. Method: We used functional magnetic resonance imaging and studied the blood-oxygen-level-dependent (BOLD) response of 45 schizophrenia outpatients and 19 healthy controls during a parametric spatial n-back task. Results: Performance in both groups deteriorated with increasing memory load (0-back, 1-back, 2-back), but the two groups did not significantly differ in performance overall or as a function of load. Patients produced stronger BOLD signal in occipital and lateral prefrontal cortex during task performance than controls. This difference increased with increasing working memory load in the prefrontal areas. We also found that in patients with good task performance, the BOLD response in left prefrontal cortex showed a stronger parametric increase with working memory load than in patients with poor performance. Second-generation antipsychotics were independently associated with left prefrontal BOLD increase in response to working memory load, whereas first-generation antipsychotics were associated with BOLD decrease with increasing load in this area. Conclusions: Together, these findings suggest that in schizophrenia patients, normal working memory task performance may be achieved through compensatory neural activity, especially in well-performing patients and in those treated with second-generation antipsychotics. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-011-2214-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 17 Subjects: – SubjectFull: Magnetic resonance imaging of the brain Type: general – SubjectFull: Short-term memory Type: general – SubjectFull: Schizophrenia Type: general – SubjectFull: Antipsychotic agents Type: general – SubjectFull: Brain imaging Type: general – SubjectFull: Oxygen in the body Type: general – SubjectFull: Prefrontal cortex Type: general – SubjectFull: Pathological psychology Type: general Titles: – TitleFull: Functional magnetic resonance imaging of a parametric working memory task in schizophrenia: relationship with performance and effects of antipsychotic treatment. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ettinger, Ulrich – PersonEntity: Name: NameFull: Williams, Steven – PersonEntity: Name: NameFull: Fannon, Dominic – PersonEntity: Name: NameFull: Premkumar, Preethi – PersonEntity: Name: NameFull: Kuipers, Elizabeth – PersonEntity: Name: NameFull: Möller, Hans-Jürgen – PersonEntity: Name: NameFull: Kumari, Veena IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 216 – Type: issue Value: 1 Titles: – TitleFull: Psychopharmacology Type: main |
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