Natural anticoagulants (antithrombin III, protein C, and protein S) in patients with mild to moderate ischemic stroke.
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| Title: | Natural anticoagulants (antithrombin III, protein C, and protein S) in patients with mild to moderate ischemic stroke. |
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| Authors: | Haapaniemi, E, Tatlisumak, T, Soinne, L, Syrjälä, M, Kaste, M |
| Source: | Acta Neurologica Scandinavica. Feb2002, Vol. 105 Issue 2, p107-114. 8p. |
| Subjects: | Anticoagulants, Coronary disease, Antithrombin III |
| Abstract: | Background and purpose – The role of the natural anticoagulants, antithrombin III (AT III), protein C (PC), and protein S (PS), in patients with mild to moderate ischemic stroke remains uncertain. We aimed to find out whether their levels in peripheral blood correlated with the severity of neurological deficit or can predict clinical outcome and recurrence. Methods – We studied AT III, PC, and free PS levels in 55 consecutive patients likely to survive the study period on admission, 1 week, 1 month and 3 months after a first-ever ischemic stroke. Sex- and age-matched controls were studied once. All patients underwent a full neurological examination and blood sampling at each study time point; comprehensive stroke risk factors were recorded, and the etiology of the ischemic stroke was determined. All patients were contacted 3 years later for possible recurrent ischemic events. Results – AT III level was found to be significantly lower at all time points after stroke; PC level was significantly increased on admission and normal at subsequent measurements, and PS level was normal on admission but significantly decreased later. The levels of the natural anticoagulants did not correlate with the etiology of stroke, any stroke risk factor, or neurological scores, except that the AT III level on admission showed significant correlation with stroke severity and disability at 3 months. Natural anticoagulant levels did not predict recurrence of ischemic stroke. Conclusions – The measurements of the level of AT III, PC, or PS did not deliver useful information for management of patients with mild or moderate ischemic stroke, expect that AT III level on admission might predict outcome. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 6114312 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Natural anticoagulants (antithrombin III, protein C, and protein S) in patients with mild to moderate ischemic stroke. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Haapaniemi%2C+E%22">Haapaniemi, E</searchLink><br /><searchLink fieldCode="AR" term="%22Tatlisumak%2C+T%22">Tatlisumak, T</searchLink><br /><searchLink fieldCode="AR" term="%22Soinne%2C+L%22">Soinne, L</searchLink><br /><searchLink fieldCode="AR" term="%22Syrjälä%2C+M%22">Syrjälä, M</searchLink><br /><searchLink fieldCode="AR" term="%22Kaste%2C+M%22">Kaste, M</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Feb2002, Vol. 105 Issue 2, p107-114. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Anticoagulants%22">Anticoagulants</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+disease%22">Coronary disease</searchLink><br /><searchLink fieldCode="DE" term="%22Antithrombin+III%22">Antithrombin III</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose – The role of the natural anticoagulants, antithrombin III (AT III), protein C (PC), and protein S (PS), in patients with mild to moderate ischemic stroke remains uncertain. We aimed to find out whether their levels in peripheral blood correlated with the severity of neurological deficit or can predict clinical outcome and recurrence. Methods – We studied AT III, PC, and free PS levels in 55 consecutive patients likely to survive the study period on admission, 1 week, 1 month and 3 months after a first-ever ischemic stroke. Sex- and age-matched controls were studied once. All patients underwent a full neurological examination and blood sampling at each study time point; comprehensive stroke risk factors were recorded, and the etiology of the ischemic stroke was determined. All patients were contacted 3 years later for possible recurrent ischemic events. Results – AT III level was found to be significantly lower at all time points after stroke; PC level was significantly increased on admission and normal at subsequent measurements, and PS level was normal on admission but significantly decreased later. The levels of the natural anticoagulants did not correlate with the etiology of stroke, any stroke risk factor, or neurological scores, except that the AT III level on admission showed significant correlation with stroke severity and disability at 3 months. Natural anticoagulant levels did not predict recurrence of ischemic stroke. Conclusions – The measurements of the level of AT III, PC, or PS did not deliver useful information for management of patients with mild or moderate ischemic stroke, expect that AT III level on admission might predict outcome. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=6114312 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1034/j.1600-0404.2002.1o112.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 107 Subjects: – SubjectFull: Anticoagulants Type: general – SubjectFull: Coronary disease Type: general – SubjectFull: Antithrombin III Type: general Titles: – TitleFull: Natural anticoagulants (antithrombin III, protein C, and protein S) in patients with mild to moderate ischemic stroke. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Haapaniemi, E – PersonEntity: Name: NameFull: Tatlisumak, T – PersonEntity: Name: NameFull: Soinne, L – PersonEntity: Name: NameFull: Syrjälä, M – PersonEntity: Name: NameFull: Kaste, M IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2002 Type: published Y: 2002 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 105 – Type: issue Value: 2 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
| ResultId | 1 |
