Intussusceptive angiogenesis: pillars against the blood flow.
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| Title: | Intussusceptive angiogenesis: pillars against the blood flow. |
|---|---|
| Authors: | Styp-Rekowska, B., Hlushchuk, R., Pries, A. R., Djonov, V. |
| Source: | Acta Physiologica. Jul2011, Vol. 202 Issue 3, p213-223. 11p. 1 Color Photograph, 2 Black and White Photographs, 3 Diagrams. |
| Subjects: | Neovascularization, Blood-vessel development, Biomechanics, Biophysics, Mechanics (Physics) |
| Abstract: | Adaptation of vascular networks to functional demands needs vessel growth, vessel regression and vascular remodelling. Biomechanical forces resulting from blood flow play a key role in these processes. It is well-known that metabolic stimuli, mechanical forces and flow patterns can affect gene expression and remodelling of vascular networks in different ways. For instance, in the sprouting type of angiogenesis related to hypoxia, there is no blood flow in the rising capillary sprout. In contrast, it has been shown that an increase of wall shear stress initiates the splitting type of angiogenesis in skeletal muscle. Otherwise, during development, both sprouting and intussusception act in parallel in building the vascular network, although with differences in spatiotemporal distribution. Thereby, in addition to regulatory molecules, flow dynamics support the patterning and remodelling of the rising vascular tree. Herewith, we present an overview of angiogenic processes with respect to intussusceptive angiogenesis as related to local haemodynamics. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 61195428 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Intussusceptive angiogenesis: pillars against the blood flow. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Styp-Rekowska%2C+B%2E%22">Styp-Rekowska, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Hlushchuk%2C+R%2E%22">Hlushchuk, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Pries%2C+A%2E+R%2E%22">Pries, A. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Djonov%2C+V%2E%22">Djonov, V.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Jul2011, Vol. 202 Issue 3, p213-223. 11p. 1 Color Photograph, 2 Black and White Photographs, 3 Diagrams. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neovascularization%22">Neovascularization</searchLink><br /><searchLink fieldCode="DE" term="%22Blood-vessel+development%22">Blood-vessel development</searchLink><br /><searchLink fieldCode="DE" term="%22Biomechanics%22">Biomechanics</searchLink><br /><searchLink fieldCode="DE" term="%22Biophysics%22">Biophysics</searchLink><br /><searchLink fieldCode="DE" term="%22Mechanics+%28Physics%29%22">Mechanics (Physics)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Adaptation of vascular networks to functional demands needs vessel growth, vessel regression and vascular remodelling. Biomechanical forces resulting from blood flow play a key role in these processes. It is well-known that metabolic stimuli, mechanical forces and flow patterns can affect gene expression and remodelling of vascular networks in different ways. For instance, in the sprouting type of angiogenesis related to hypoxia, there is no blood flow in the rising capillary sprout. In contrast, it has been shown that an increase of wall shear stress initiates the splitting type of angiogenesis in skeletal muscle. Otherwise, during development, both sprouting and intussusception act in parallel in building the vascular network, although with differences in spatiotemporal distribution. Thereby, in addition to regulatory molecules, flow dynamics support the patterning and remodelling of the rising vascular tree. Herewith, we present an overview of angiogenic processes with respect to intussusceptive angiogenesis as related to local haemodynamics. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=61195428 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1748-1716.2011.02321.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 213 Subjects: – SubjectFull: Neovascularization Type: general – SubjectFull: Blood-vessel development Type: general – SubjectFull: Biomechanics Type: general – SubjectFull: Biophysics Type: general – SubjectFull: Mechanics (Physics) Type: general Titles: – TitleFull: Intussusceptive angiogenesis: pillars against the blood flow. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Styp-Rekowska, B. – PersonEntity: Name: NameFull: Hlushchuk, R. – PersonEntity: Name: NameFull: Pries, A. R. – PersonEntity: Name: NameFull: Djonov, V. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 17481708 Numbering: – Type: volume Value: 202 – Type: issue Value: 3 Titles: – TitleFull: Acta Physiologica Type: main |
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