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Neurochemical organization and experience-dependent activation of estrogen-associated circuits in the songbird auditory forebrain.

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Title: Neurochemical organization and experience-dependent activation of estrogen-associated circuits in the songbird auditory forebrain.
Authors: Jeong, Jin Kwon (AUTHOR), Burrows, Kaiping (AUTHOR), Tremere, Liisa A. (AUTHOR), Pinaud, Raphael (AUTHOR)
Source: European Journal of Neuroscience. Jul2011, Vol. 34 Issue 2, p283-291. 9p. 2 Color Photographs, 2 Graphs.
Subjects: Neurochemistry, Activation (Chemistry), Estrogen, Songbirds, Prosencephalon, Estradiol, Glutamic acid
Abstract: The classic steroid hormone estradiol is rapidly produced by central auditory neurons in the songbird brain and instantaneously modulates auditory coding to enhance the neural and behavioral discrimination of acoustic signals. Although recent advances highlight novel roles for estradiol in the regulation of central auditory processing, current knowledge on the functional and neurochemical organization of estrogen‐associated circuits, as well as the impact of sensory experience in these auditory forebrain networks, remains very limited. Here we show that both estrogen‐producing and ‐sensitive neurons are highly expressed in the caudomedial nidopallium (NCM), the zebra finch analog of the mammalian auditory association cortex, but not other auditory forebrain areas. We further demonstrate that auditory experience primarily engages estrogen‐producing, and to a lesser extent, estrogen‐responsive neurons in NCM, that these neuronal populations moderately overlap and that acute episodes of sensory experience do not quantitatively affect these circuits. Finally, we show that whereas estrogen‐producing cells are neurochemically heterogeneous, estrogen‐sensitive neurons are primarily glutamatergic. These findings reveal the neurochemical and functional organization of estrogen‐associated circuits in the auditory forebrain, demonstrate their activation and stability in response to sensory experience in behaving animals, and highlight estrogenic circuits as fundamental components of central networks supporting sensory processing. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Neurochemical organization and experience-dependent activation of estrogen-associated circuits in the songbird auditory forebrain.
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  Data: <searchLink fieldCode="AR" term="%22Jeong%2C+Jin+Kwon%22">Jeong, Jin Kwon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burrows%2C+Kaiping%22">Burrows, Kaiping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tremere%2C+Liisa+A%2E%22">Tremere, Liisa A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pinaud%2C+Raphael%22">Pinaud, Raphael</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jul2011, Vol. 34 Issue 2, p283-291. 9p. 2 Color Photographs, 2 Graphs.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Neurochemistry%22">Neurochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Activation+%28Chemistry%29%22">Activation (Chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Estrogen%22">Estrogen</searchLink><br /><searchLink fieldCode="DE" term="%22Songbirds%22">Songbirds</searchLink><br /><searchLink fieldCode="DE" term="%22Prosencephalon%22">Prosencephalon</searchLink><br /><searchLink fieldCode="DE" term="%22Estradiol%22">Estradiol</searchLink><br /><searchLink fieldCode="DE" term="%22Glutamic+acid%22">Glutamic acid</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The classic steroid hormone estradiol is rapidly produced by central auditory neurons in the songbird brain and instantaneously modulates auditory coding to enhance the neural and behavioral discrimination of acoustic signals. Although recent advances highlight novel roles for estradiol in the regulation of central auditory processing, current knowledge on the functional and neurochemical organization of estrogen‐associated circuits, as well as the impact of sensory experience in these auditory forebrain networks, remains very limited. Here we show that both estrogen‐producing and ‐sensitive neurons are highly expressed in the caudomedial nidopallium (NCM), the zebra finch analog of the mammalian auditory association cortex, but not other auditory forebrain areas. We further demonstrate that auditory experience primarily engages estrogen‐producing, and to a lesser extent, estrogen‐responsive neurons in NCM, that these neuronal populations moderately overlap and that acute episodes of sensory experience do not quantitatively affect these circuits. Finally, we show that whereas estrogen‐producing cells are neurochemically heterogeneous, estrogen‐sensitive neurons are primarily glutamatergic. These findings reveal the neurochemical and functional organization of estrogen‐associated circuits in the auditory forebrain, demonstrate their activation and stability in response to sensory experience in behaving animals, and highlight estrogenic circuits as fundamental components of central networks supporting sensory processing. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=62960730
RecordInfo BibRecord:
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        Value: 10.1111/j.1460-9568.2011.07743.x
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      – Code: eng
        Text: English
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      – SubjectFull: Estrogen
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      – SubjectFull: Songbirds
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      – SubjectFull: Prosencephalon
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      – SubjectFull: Estradiol
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            NameFull: Jeong, Jin Kwon
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            NameFull: Tremere, Liisa A.
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              Text: Jul2011
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              Y: 2011
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