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Intrathecal IgG synthesis: marker of progression in multiple sclerosis patients.

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Title: Intrathecal IgG synthesis: marker of progression in multiple sclerosis patients.
Authors: Izquierdo, G, Angulo, S, Garcia-Moreno, J. M, Gamero, M. A, Navarro, G, Gata, J. M, Ruiz-Peña, J. L, Páramo, M. D
Source: Acta Neurologica Scandinavica. Mar2002, Vol. 105 Issue 3, p158-163. 6p.
Subjects: Multiple sclerosis, Immunoglobulin G
Abstract: Objectives – We study the power of IgG synthesis value as a marker of disease activity in multiple sclerosis (MS). Material and methods – Link index was calculated in 202 MS patients. Time between first, second and third attack and progression index (PI) were compared in patient with normal (NLI) high (HL) or very high Link index (VHLI). Results – Secondary progressive (SP) patients had a higher LI than relapsing–remitting (RR) and primary progressive (PP) courses (1.10 ± 0.5 for SP vs 0.86 ± 0.5 for RR and 0.81 ± 0.5 for PP, P =0.01 and 0.03, respectively). Having a HLI in MS RR and SP patients has no time effect in the development of the second and third attack. PI was higher in patients with VHIL (0.67 ± 0.7) vs patients with NLI (0.42 ± 0.4, P =0.008) and with HLI (0.39 ± 0.3, P =0.001). Conclusions – This study confirmed that LI is a good marker of subsequent progression of MS. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Intrathecal IgG synthesis: marker of progression in multiple sclerosis patients.
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  Data: <searchLink fieldCode="AR" term="%22Izquierdo%2C+G%22">Izquierdo, G</searchLink><br /><searchLink fieldCode="AR" term="%22Angulo%2C+S%22">Angulo, S</searchLink><br /><searchLink fieldCode="AR" term="%22Garcia-Moreno%2C+J%2E+M%22">Garcia-Moreno, J. M</searchLink><br /><searchLink fieldCode="AR" term="%22Gamero%2C+M%2E+A%22">Gamero, M. A</searchLink><br /><searchLink fieldCode="AR" term="%22Navarro%2C+G%22">Navarro, G</searchLink><br /><searchLink fieldCode="AR" term="%22Gata%2C+J%2E+M%22">Gata, J. M</searchLink><br /><searchLink fieldCode="AR" term="%22Ruiz-Peña%2C+J%2E+L%22">Ruiz-Peña, J. L</searchLink><br /><searchLink fieldCode="AR" term="%22Páramo%2C+M%2E+D%22">Páramo, M. D</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Mar2002, Vol. 105 Issue 3, p158-163. 6p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulin+G%22">Immunoglobulin G</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives – We study the power of IgG synthesis value as a marker of disease activity in multiple sclerosis (MS). Material and methods – Link index was calculated in 202 MS patients. Time between first, second and third attack and progression index (PI) were compared in patient with normal (NLI) high (HL) or very high Link index (VHLI). Results – Secondary progressive (SP) patients had a higher LI than relapsing–remitting (RR) and primary progressive (PP) courses (1.10 ± 0.5 for SP vs 0.86 ± 0.5 for RR and 0.81 ± 0.5 for PP, P =0.01 and 0.03, respectively). Having a HLI in MS RR and SP patients has no time effect in the development of the second and third attack. PI was higher in patients with VHIL (0.67 ± 0.7) vs patients with NLI (0.42 ± 0.4, P =0.008) and with HLI (0.39 ± 0.3, P =0.001). Conclusions – This study confirmed that LI is a good marker of subsequent progression of MS. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1034/j.1600-0404.2002.1o009.x
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