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5-HT1A receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups.

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Title: 5-HT1A receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups.
Authors: Bailer, Ursula F. (AUTHOR), Bloss, Cinnamon S. (AUTHOR), Frank, Guido K. (AUTHOR), Price, Julie C. (AUTHOR), Meltzer, Carolyn C. (AUTHOR), Mathis, Chester A. (AUTHOR), Geyer, Mark A. (AUTHOR), Wagner, Angela (AUTHOR), Becker, Carl R. (AUTHOR), Schork, Nicholas J. (AUTHOR), Kaye, Walter H. (AUTHOR)
Source: International Journal of Eating Disorders. Sep2011, Vol. 44 Issue 6, p477-487. 11p. 3 Charts, 2 Graphs.
Subjects: Blood testing, Analysis of variance, Anxiety testing, Bulimia, Comparative studies, Convalescence, Interviewing, Magnetic resonance imaging, Regression analysis, Self-report inventories, Statistics, Positron emission tomography, Serotonin agonists, Sample size (Statistics), Data analysis, Repeated measures design, Data analysis software
Abstract: Objective Because altered serotonin (5-HT) function appears to persist after recovery from bulimia nervosa (RBN), we investigated the 5-HT1A receptor, which could contribute to regulation of appetite, mood, impulse control, or the response to antidepressants. Method Thirteen RBN individuals were compared to 21 healthy control women (CW) using positron emission tomography and [carbonyl-11C]WAY100635 ([11C]WAY). Results RBN had a 23-34% elevation of [11C]WAY binding potential (BP)P in subgenual cingulate, mesial temporal, and parietal regions after adjustments for multiple comparisons. For CW, [11C]WAY BPP was related negatively to novelty seeking, whereas for RBN, [11C]WAY BPP was related positively to harm avoidance and negatively related to sensation seeking. Discussion Alterations of 5-HT1A receptor function may provide new insight into efficacy of 5-HT medication in BN, as well as symptoms such as the ability to inhibit or self-control the expression of behaviors related to stimulus seeking, aggression, and impulsivity. © 2010 by Wiley Periodicals, Inc. Int J Eat Disord 2011 [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: 5-HT<subscript>1A</subscript> receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups.
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Eating+Disorders%22">International Journal of Eating Disorders</searchLink>. Sep2011, Vol. 44 Issue 6, p477-487. 11p. 3 Charts, 2 Graphs.
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  Label: Abstract
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  Data: Objective Because altered serotonin (5-HT) function appears to persist after recovery from bulimia nervosa (RBN), we investigated the 5-HT1A receptor, which could contribute to regulation of appetite, mood, impulse control, or the response to antidepressants. Method Thirteen RBN individuals were compared to 21 healthy control women (CW) using positron emission tomography and [carbonyl-11C]WAY100635 ([11C]WAY). Results RBN had a 23-34% elevation of [11C]WAY binding potential (BP)P in subgenual cingulate, mesial temporal, and parietal regions after adjustments for multiple comparisons. For CW, [11C]WAY BPP was related negatively to novelty seeking, whereas for RBN, [11C]WAY BPP was related positively to harm avoidance and negatively related to sensation seeking. Discussion Alterations of 5-HT1A receptor function may provide new insight into efficacy of 5-HT medication in BN, as well as symptoms such as the ability to inhibit or self-control the expression of behaviors related to stimulus seeking, aggression, and impulsivity. © 2010 by Wiley Periodicals, Inc. Int J Eat Disord 2011 [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/eat.20843
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        Text: English
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      – SubjectFull: Blood testing
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      – SubjectFull: Analysis of variance
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      – SubjectFull: Anxiety testing
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