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Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury.

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Title: Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury.
Authors: Ikezono, Tetsuo (AUTHOR), Shindo, Susumu (AUTHOR), Sekine, Kuwon (AUTHOR), Shiiba, Kyoko (AUTHOR), Matsuda, Han (AUTHOR), Kusama, Kaoru (AUTHOR), Koizumi, Yasuo (AUTHOR), Sugizaki, Kazuki (AUTHOR), Sekiguchi, Satomi (AUTHOR), Kataoka, Ryohei (AUTHOR), Pawankar, Ruby (AUTHOR), Baba, Shunkichi (AUTHOR), Yagi, Toshiaki (AUTHOR), Okubo, Kimihiro (AUTHOR)
Source: Acta Oto-Laryngologica. Sep2011, Vol. 131 Issue 9, p937-944. 8p. 2 Black and White Photographs, 1 Chart, 1 Graph.
Subjects: Middle ear, Inner ear, Audiometry, Inner ear diseases, Biomarkers, Deafness, Longitudinal method, Penetrating wounds, Research funding, Tomography, Tympanic membrane, Vertigo, Western immunoblotting, Diagnosis, Wounds & injuries
Abstract: Conclusions: The cochlin-tomoprotein (CTP) detection test can be used to make a definite, objective diagnosis of traumatic perilymphatic fistula (PLF), and therefore offers valuable information on patient selection for surgical treatment. Objectives: Penetrating middle ear injury can cause traumatic PLF, which is a surgically treatable otologic emergency. Recently, we have reported on CTP, a novel perilymph-specific protein. The purpose of this study was to determine if the CTP detection test is useful for the diagnosis of traumatic PLF. Methods: This was a prospective study of CTP detection in penetrating middle ear injury cases with tympanic membrane perforation and hearing loss. Results: A total of seven individuals were included in this study. CTP was detected in three of four cases with posterosuperior quadrant perforation of the tympanic membrane. In one of these three cases, even though the high resolution CT scan was not suggestive of PLF and the perilymph leakage could not be visualized intraoperatively, the CTP detection test was able to detect PLF. In two cases, the preoperative positive test results enabled us to make a diagnosis of PLF and a decision for surgical treatment. CTP was not detected in the cases with anterior or inferior tympanic membrane perforation. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Ikezono%2C+Tetsuo%22">Ikezono, Tetsuo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shindo%2C+Susumu%22">Shindo, Susumu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sekine%2C+Kuwon%22">Sekine, Kuwon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shiiba%2C+Kyoko%22">Shiiba, Kyoko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Matsuda%2C+Han%22">Matsuda, Han</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kusama%2C+Kaoru%22">Kusama, Kaoru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koizumi%2C+Yasuo%22">Koizumi, Yasuo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sugizaki%2C+Kazuki%22">Sugizaki, Kazuki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sekiguchi%2C+Satomi%22">Sekiguchi, Satomi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kataoka%2C+Ryohei%22">Kataoka, Ryohei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pawankar%2C+Ruby%22">Pawankar, Ruby</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baba%2C+Shunkichi%22">Baba, Shunkichi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yagi%2C+Toshiaki%22">Yagi, Toshiaki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Okubo%2C+Kimihiro%22">Okubo, Kimihiro</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Sep2011, Vol. 131 Issue 9, p937-944. 8p. 2 Black and White Photographs, 1 Chart, 1 Graph.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Middle+ear%22">Middle ear</searchLink><br /><searchLink fieldCode="DE" term="%22Inner+ear%22">Inner ear</searchLink><br /><searchLink fieldCode="DE" term="%22Audiometry%22">Audiometry</searchLink><br /><searchLink fieldCode="DE" term="%22Inner+ear+diseases%22">Inner ear diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Deafness%22">Deafness</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Penetrating+wounds%22">Penetrating wounds</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Tomography%22">Tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Tympanic+membrane%22">Tympanic membrane</searchLink><br /><searchLink fieldCode="DE" term="%22Vertigo%22">Vertigo</searchLink><br /><searchLink fieldCode="DE" term="%22Western+immunoblotting%22">Western immunoblotting</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Wounds+%26+injuries%22">Wounds & injuries</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Conclusions: The cochlin-tomoprotein (CTP) detection test can be used to make a definite, objective diagnosis of traumatic perilymphatic fistula (PLF), and therefore offers valuable information on patient selection for surgical treatment. Objectives: Penetrating middle ear injury can cause traumatic PLF, which is a surgically treatable otologic emergency. Recently, we have reported on CTP, a novel perilymph-specific protein. The purpose of this study was to determine if the CTP detection test is useful for the diagnosis of traumatic PLF. Methods: This was a prospective study of CTP detection in penetrating middle ear injury cases with tympanic membrane perforation and hearing loss. Results: A total of seven individuals were included in this study. CTP was detected in three of four cases with posterosuperior quadrant perforation of the tympanic membrane. In one of these three cases, even though the high resolution CT scan was not suggestive of PLF and the perilymph leakage could not be visualized intraoperatively, the CTP detection test was able to detect PLF. In two cases, the preoperative positive test results enabled us to make a diagnosis of PLF and a decision for surgical treatment. CTP was not detected in the cases with anterior or inferior tympanic membrane perforation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.3109/00016489.2011.575795
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 937
    Subjects:
      – SubjectFull: Middle ear
        Type: general
      – SubjectFull: Inner ear
        Type: general
      – SubjectFull: Audiometry
        Type: general
      – SubjectFull: Inner ear diseases
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      – SubjectFull: Biomarkers
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      – SubjectFull: Deafness
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      – SubjectFull: Longitudinal method
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      – SubjectFull: Penetrating wounds
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      – SubjectFull: Tomography
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      – SubjectFull: Vertigo
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      – SubjectFull: Western immunoblotting
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      – SubjectFull: Diagnosis
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      – SubjectFull: Wounds & injuries
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      – TitleFull: Cochlin-tomoprotein (CTP) detection test identifies traumatic perilymphatic fistula due to penetrating middle ear injury.
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