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Vitamin A deficiency and genital viral burden in women infected with HIV-1.

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Title: Vitamin A deficiency and genital viral burden in women infected with HIV-1.
Authors: French, Audrey L, Cohen, Mardge H, Gange, Stephen J, Burger, Harold, Gao, Wei, Semba, Richard D, Meyer III, William A, Robison, Esther, Anastos, Kathryn
Source: Lancet. 4/6/2002, Vol. 359 Issue 9313, p1210. 3p. 1 Chart, 1 Graph.
Subjects: HIV infection transmission, Vitamin A, HIV-positive women, Pregnancy complications, Medical care
Abstract: The relation between vitamin A (retinol) deficiency and perinatal transmission of HIV-1, if it exists, might be mediated through an increased viral load in the mother's genital tract. To ascertain whether or not such an association is present, we measured the serum concentration of retinol with high performance liquid chromatography, and correlated the results with concurrent quantified HIV-1 RNA concentrations in cervicovaginal lavage fluid in 301 women infected with the virus. We noted no association between retinol status and genital HIV-1 load. Our findings lend support to those of studies that reported no association between retinol deficiency and perinatal HIV-1 transmission. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Vitamin A deficiency and genital viral burden in women infected with HIV-1.
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  Data: <searchLink fieldCode="AR" term="%22French%2C+Audrey+L%22">French, Audrey L</searchLink><br /><searchLink fieldCode="AR" term="%22Cohen%2C+Mardge+H%22">Cohen, Mardge H</searchLink><br /><searchLink fieldCode="AR" term="%22Gange%2C+Stephen+J%22">Gange, Stephen J</searchLink><br /><searchLink fieldCode="AR" term="%22Burger%2C+Harold%22">Burger, Harold</searchLink><br /><searchLink fieldCode="AR" term="%22Gao%2C+Wei%22">Gao, Wei</searchLink><br /><searchLink fieldCode="AR" term="%22Semba%2C+Richard+D%22">Semba, Richard D</searchLink><br /><searchLink fieldCode="AR" term="%22Meyer+III%2C+William+A%22">Meyer III, William A</searchLink><br /><searchLink fieldCode="AR" term="%22Robison%2C+Esther%22">Robison, Esther</searchLink><br /><searchLink fieldCode="AR" term="%22Anastos%2C+Kathryn%22">Anastos, Kathryn</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 4/6/2002, Vol. 359 Issue 9313, p1210. 3p. 1 Chart, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22HIV+infection+transmission%22">HIV infection transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Vitamin+A%22">Vitamin A</searchLink><br /><searchLink fieldCode="DE" term="%22HIV-positive+women%22">HIV-positive women</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy+complications%22">Pregnancy complications</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+care%22">Medical care</searchLink>
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  Data: The relation between vitamin A (retinol) deficiency and perinatal transmission of HIV-1, if it exists, might be mediated through an increased viral load in the mother's genital tract. To ascertain whether or not such an association is present, we measured the serum concentration of retinol with high performance liquid chromatography, and correlated the results with concurrent quantified HIV-1 RNA concentrations in cervicovaginal lavage fluid in 301 women infected with the virus. We noted no association between retinol status and genital HIV-1 load. Our findings lend support to those of studies that reported no association between retinol deficiency and perinatal HIV-1 transmission. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/S0140-6736(02)08226-0
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        Text: English
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      – SubjectFull: HIV-positive women
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              Text: 4/6/2002
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              Y: 2002
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