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Neuronal Calcium Sensor 1 and Activity-Dependent Facilitation of P/Q-Type Calcium Currents at Presynaptic Nerve Terminals.

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Title: Neuronal Calcium Sensor 1 and Activity-Dependent Facilitation of P/Q-Type Calcium Currents at Presynaptic Nerve Terminals.
Authors: Tsujimoto, Tetsuhiro, Jeromin, Andreas, Saitoh, Naoto, Roder, John C., Takahashi, Tomoyuki
Source: Science (pre-March 2025). 3/22/2002, Vol. 295 Issue 5563, p2276. 4p. 1 Color Photograph, 3 Graphs, 1 Map.
Subjects: Neurotransmitters, Calcium channels
Abstract: P/Q-type presynaptic calcium currents (I[sub pCa]) undergo activity-dependent facilitation during repetitive activation at the calyx of the Held synapse. We investigated whether neuronal calcium sensor 1 (NCS-1) may underlie this phenomenon. Direct loading of NCS-1 into the nerve terminal mimicked activity-dependent I[sub pCa] facilitation by accelerating the activation time of I[sub pCa] in a Ca[sup 2+]-dependent manner. A presynaptically loaded carboxyl-terminal peptide of NCS-1 abolished I[sub pCa] facilitation. These results suggest that residual Ca[sup 2+] activates endogenous NCS-1, thereby facilitating I[sub pCa]. Because both p/Q-type Ca[sup 2+] channels and NCS-1 are widely expressed in mammalian nerve terminals, NCS-1 may contribute to the activity-dependent synaptic facilitation at many synapses. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Neuronal Calcium Sensor 1 and Activity-Dependent Facilitation of P/Q-Type Calcium Currents at Presynaptic Nerve Terminals.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Tsujimoto%2C+Tetsuhiro%22">Tsujimoto, Tetsuhiro</searchLink><br /><searchLink fieldCode="AR" term="%22Jeromin%2C+Andreas%22">Jeromin, Andreas</searchLink><br /><searchLink fieldCode="AR" term="%22Saitoh%2C+Naoto%22">Saitoh, Naoto</searchLink><br /><searchLink fieldCode="AR" term="%22Roder%2C+John+C%2E%22">Roder, John C.</searchLink><br /><searchLink fieldCode="AR" term="%22Takahashi%2C+Tomoyuki%22">Takahashi, Tomoyuki</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 3/22/2002, Vol. 295 Issue 5563, p2276. 4p. 1 Color Photograph, 3 Graphs, 1 Map.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Neurotransmitters%22">Neurotransmitters</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+channels%22">Calcium channels</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: P/Q-type presynaptic calcium currents (I[sub pCa]) undergo activity-dependent facilitation during repetitive activation at the calyx of the Held synapse. We investigated whether neuronal calcium sensor 1 (NCS-1) may underlie this phenomenon. Direct loading of NCS-1 into the nerve terminal mimicked activity-dependent I[sub pCa] facilitation by accelerating the activation time of I[sub pCa] in a Ca[sup 2+]-dependent manner. A presynaptically loaded carboxyl-terminal peptide of NCS-1 abolished I[sub pCa] facilitation. These results suggest that residual Ca[sup 2+] activates endogenous NCS-1, thereby facilitating I[sub pCa]. Because both p/Q-type Ca[sup 2+] channels and NCS-1 are widely expressed in mammalian nerve terminals, NCS-1 may contribute to the activity-dependent synaptic facilitation at many synapses. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1126/science.1068278
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      – Code: eng
        Text: English
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        PageCount: 4
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      – SubjectFull: Neurotransmitters
        Type: general
      – SubjectFull: Calcium channels
        Type: general
    Titles:
      – TitleFull: Neuronal Calcium Sensor 1 and Activity-Dependent Facilitation of P/Q-Type Calcium Currents at Presynaptic Nerve Terminals.
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            NameFull: Jeromin, Andreas
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            – D: 22
              M: 03
              Text: 3/22/2002
              Type: published
              Y: 2002
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