Tolerance to the Beneficial Effects of Prophylactic Migraine Drugs: A Systematic Review of Causes and Mechanisms.
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| Title: | Tolerance to the Beneficial Effects of Prophylactic Migraine Drugs: A Systematic Review of Causes and Mechanisms. |
|---|---|
| Authors: | Rizzoli, Paul, Loder, Elizabeth W. |
| Source: | Headache: The Journal of Head & Face Pain. Sep2011, Vol. 51 Issue 8, p1323-1335. 13p. |
| Subjects: | Migraine prevention, Drug tolerance, Analysis of variance, Migraine, Research funding, Systematic reviews |
| Abstract: | Loss of benefit of a previously effective treatment regimen, also known as tolerance, can be an important barrier to the successful preventive treatment of migraine. We undertook a systematic review of the literature to identify the prevalence and possible mechanisms of drug tolerance in migraine prophylaxis. Results demonstrate that the frequency of tolerance to prophylactic migraine treatment is unknown, but available data support an estimate that it occurs in 1-8% of patients receiving prophylaxis. Four broad types of tolerance were identified that are likely to be relevant to migraine prophylaxis. These are pharmacokinetic, pharmacodynamic, behavioral, and cross tolerance. The mechanisms that underlie these types of tolerance determine whether their effects can be overcome or minimized. For example, certain forms of tolerance may be affected by manipulation of environmental cues associated with drug administration, by the order in which drugs are used, and by the concomitant use of other medications. Many medications used for migraine prophylaxis exert their effects through the endogenous opioid system. The implications of this finding are explored, particularly the parallels between medication overuse headache and tolerance to migraine prophylaxis. Given the many ways in which tolerance to migraine medications may develop, in some ways it is not surprising that migraine-preventive drugs stop working; it is more surprising that in many cases they do not. [ABSTRACT FROM AUTHOR] |
| Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 65152482 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Tolerance to the Beneficial Effects of Prophylactic Migraine Drugs: A Systematic Review of Causes and Mechanisms. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rizzoli%2C+Paul%22">Rizzoli, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Loder%2C+Elizabeth+W%2E%22">Loder, Elizabeth W.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Headache%3A+The+Journal+of+Head+%26+Face+Pain%22">Headache: The Journal of Head & Face Pain</searchLink>. Sep2011, Vol. 51 Issue 8, p1323-1335. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Migraine+prevention%22">Migraine prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+tolerance%22">Drug tolerance</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Loss of benefit of a previously effective treatment regimen, also known as tolerance, can be an important barrier to the successful preventive treatment of migraine. We undertook a systematic review of the literature to identify the prevalence and possible mechanisms of drug tolerance in migraine prophylaxis. Results demonstrate that the frequency of tolerance to prophylactic migraine treatment is unknown, but available data support an estimate that it occurs in 1-8% of patients receiving prophylaxis. Four broad types of tolerance were identified that are likely to be relevant to migraine prophylaxis. These are pharmacokinetic, pharmacodynamic, behavioral, and cross tolerance. The mechanisms that underlie these types of tolerance determine whether their effects can be overcome or minimized. For example, certain forms of tolerance may be affected by manipulation of environmental cues associated with drug administration, by the order in which drugs are used, and by the concomitant use of other medications. Many medications used for migraine prophylaxis exert their effects through the endogenous opioid system. The implications of this finding are explored, particularly the parallels between medication overuse headache and tolerance to migraine prophylaxis. Given the many ways in which tolerance to migraine medications may develop, in some ways it is not surprising that migraine-preventive drugs stop working; it is more surprising that in many cases they do not. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Headache: The Journal of Head & Face Pain is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=65152482 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1526-4610.2011.01985.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1323 Subjects: – SubjectFull: Migraine prevention Type: general – SubjectFull: Drug tolerance Type: general – SubjectFull: Analysis of variance Type: general – SubjectFull: Migraine Type: general – SubjectFull: Research funding Type: general – SubjectFull: Systematic reviews Type: general Titles: – TitleFull: Tolerance to the Beneficial Effects of Prophylactic Migraine Drugs: A Systematic Review of Causes and Mechanisms. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rizzoli, Paul – PersonEntity: Name: NameFull: Loder, Elizabeth W. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00178748 Numbering: – Type: volume Value: 51 – Type: issue Value: 8 Titles: – TitleFull: Headache: The Journal of Head & Face Pain Type: main |
| ResultId | 1 |
