Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission.
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| Title: | Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission. |
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| Authors: | Ago, Yukio, Araki, Ryota, Yano, Koji, Hiramatsu, Naoki, Kawasaki, Toshiyuki, Chaki, Shigeyuki, Nakazato, Atsuro, Onoe, Hirotaka, Hashimoto, Hitoshi, Baba, Akemichi, Takuma, Kazuhiro, Matsuda, Toshio |
| Source: | Psychopharmacology. Oct2011, Vol. 217 Issue 3, p443-452. 10p. 1 Chart, 7 Graphs. |
| Subjects: | Glutamic acid, Methamphetamine, Prefrontal cortex, Serotoninergic mechanisms, Neural transmission, Side effects of antipsychotic drugs, Nucleus accumbens, Serotonin |
| Abstract: | Rationale: Metabotropic glutamate (mGlu) 2/3 receptor agonists inhibit amphetamine- and phencyclidine-induced hyperlocomotion. The mechanism for the antipsychotic effect of mGlu2/3 receptor agonists was studied in a hypoglutamatergic model, but not a hyperdopaminergic model. Objectives: To study the mechanism for the antipsychotic effect of the agonist in the hyperdopaminergic model, this study examined the effects of the selective mGlu2/3 receptor agonist MGS0028 on methamphetamine-induced hyperlocomotion and the increases in extracellular levels of serotonin, dopamine, noradrenaline, and glutamate in the prefrontal cortex and nucleus accumbens of mice. Results: Systemic administration of MGS0028 attenuated methamphetamine-induced hyperlocomotion in a dose-dependent manner. Microdialysis studies showed that MGS0028 significantly inhibited methamphetamine-induced increases in the extracellular serotonin, but not dopamine and noradrenaline, levels in the prefrontal cortex, and it did not affect methamphetamine-induced increases in the extracellular amine levels in the nucleus accumbens. Methamphetamine did not affect the glutamate release in the prefrontal cortex and nucleus accumbens. Local application of MGS0028 into the prefrontal cortex also attenuated methamphetamine-induced hyperlocomotion and increases in the extracellular serotonin levels in the prefrontal cortex. Moreover, MGS0028 did not affect methamphetamine-induced hyperlocomotion in the mice pretreated with p-chlorophenylalanine, a serotonin synthesis inhibitor. Conclusions: Activation of prefrontal mGlu2/3 receptors inhibits the psychomotor stimulant effect of methamphetamine in mice, and the prefrontal serotonergic system may be involved in this effect. The finding provides evidence that prefrontal mGlu2/3 receptors are functionally coupled with the serotonergic system. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 65243586 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ago%2C+Yukio%22">Ago, Yukio</searchLink><br /><searchLink fieldCode="AR" term="%22Araki%2C+Ryota%22">Araki, Ryota</searchLink><br /><searchLink fieldCode="AR" term="%22Yano%2C+Koji%22">Yano, Koji</searchLink><br /><searchLink fieldCode="AR" term="%22Hiramatsu%2C+Naoki%22">Hiramatsu, Naoki</searchLink><br /><searchLink fieldCode="AR" term="%22Kawasaki%2C+Toshiyuki%22">Kawasaki, Toshiyuki</searchLink><br /><searchLink fieldCode="AR" term="%22Chaki%2C+Shigeyuki%22">Chaki, Shigeyuki</searchLink><br /><searchLink fieldCode="AR" term="%22Nakazato%2C+Atsuro%22">Nakazato, Atsuro</searchLink><br /><searchLink fieldCode="AR" term="%22Onoe%2C+Hirotaka%22">Onoe, Hirotaka</searchLink><br /><searchLink fieldCode="AR" term="%22Hashimoto%2C+Hitoshi%22">Hashimoto, Hitoshi</searchLink><br /><searchLink fieldCode="AR" term="%22Baba%2C+Akemichi%22">Baba, Akemichi</searchLink><br /><searchLink fieldCode="AR" term="%22Takuma%2C+Kazuhiro%22">Takuma, Kazuhiro</searchLink><br /><searchLink fieldCode="AR" term="%22Matsuda%2C+Toshio%22">Matsuda, Toshio</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Oct2011, Vol. 217 Issue 3, p443-452. 10p. 1 Chart, 7 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Glutamic+acid%22">Glutamic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Methamphetamine%22">Methamphetamine</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Serotoninergic+mechanisms%22">Serotoninergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Side+effects+of+antipsychotic+drugs%22">Side effects of antipsychotic drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleus+accumbens%22">Nucleus accumbens</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Metabotropic glutamate (mGlu) 2/3 receptor agonists inhibit amphetamine- and phencyclidine-induced hyperlocomotion. The mechanism for the antipsychotic effect of mGlu2/3 receptor agonists was studied in a hypoglutamatergic model, but not a hyperdopaminergic model. Objectives: To study the mechanism for the antipsychotic effect of the agonist in the hyperdopaminergic model, this study examined the effects of the selective mGlu2/3 receptor agonist MGS0028 on methamphetamine-induced hyperlocomotion and the increases in extracellular levels of serotonin, dopamine, noradrenaline, and glutamate in the prefrontal cortex and nucleus accumbens of mice. Results: Systemic administration of MGS0028 attenuated methamphetamine-induced hyperlocomotion in a dose-dependent manner. Microdialysis studies showed that MGS0028 significantly inhibited methamphetamine-induced increases in the extracellular serotonin, but not dopamine and noradrenaline, levels in the prefrontal cortex, and it did not affect methamphetamine-induced increases in the extracellular amine levels in the nucleus accumbens. Methamphetamine did not affect the glutamate release in the prefrontal cortex and nucleus accumbens. Local application of MGS0028 into the prefrontal cortex also attenuated methamphetamine-induced hyperlocomotion and increases in the extracellular serotonin levels in the prefrontal cortex. Moreover, MGS0028 did not affect methamphetamine-induced hyperlocomotion in the mice pretreated with p-chlorophenylalanine, a serotonin synthesis inhibitor. Conclusions: Activation of prefrontal mGlu2/3 receptors inhibits the psychomotor stimulant effect of methamphetamine in mice, and the prefrontal serotonergic system may be involved in this effect. The finding provides evidence that prefrontal mGlu2/3 receptors are functionally coupled with the serotonergic system. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-011-2295-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 443 Subjects: – SubjectFull: Glutamic acid Type: general – SubjectFull: Methamphetamine Type: general – SubjectFull: Prefrontal cortex Type: general – SubjectFull: Serotoninergic mechanisms Type: general – SubjectFull: Neural transmission Type: general – SubjectFull: Side effects of antipsychotic drugs Type: general – SubjectFull: Nucleus accumbens Type: general – SubjectFull: Serotonin Type: general Titles: – TitleFull: Activation of metabotropic glutamate 2/3 receptors attenuates methamphetamine-induced hyperlocomotion and increase in prefrontal serotonergic neurotransmission. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ago, Yukio – PersonEntity: Name: NameFull: Araki, Ryota – PersonEntity: Name: NameFull: Yano, Koji – PersonEntity: Name: NameFull: Hiramatsu, Naoki – PersonEntity: Name: NameFull: Kawasaki, Toshiyuki – PersonEntity: Name: NameFull: Chaki, Shigeyuki – PersonEntity: Name: NameFull: Nakazato, Atsuro – PersonEntity: Name: NameFull: Onoe, Hirotaka – PersonEntity: Name: NameFull: Hashimoto, Hitoshi – PersonEntity: Name: NameFull: Baba, Akemichi – PersonEntity: Name: NameFull: Takuma, Kazuhiro – PersonEntity: Name: NameFull: Matsuda, Toshio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 217 – Type: issue Value: 3 Titles: – TitleFull: Psychopharmacology Type: main |
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