Comparison of Purified Plant Polysaccharide (HemoStase) Versus Gelatin-Thrombin Matrix (FloSeal) in Controlling Bleeding During Sinus Surgery: A Randomized Controlled Trial.
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| Title: | Comparison of Purified Plant Polysaccharide (HemoStase) Versus Gelatin-Thrombin Matrix (FloSeal) in Controlling Bleeding During Sinus Surgery: A Randomized Controlled Trial. |
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| Authors: | Beyea, Jason A. (AUTHOR), Rotenberg, Brian W. (AUTHOR) |
| Source: | Annals of Otology, Rhinology & Laryngology. Aug2011, Vol. 120 Issue 8, p495-498. 4p. 2 Black and White Photographs, 1 Chart, 1 Graph. |
| Subjects: | Operative surgery, Intraoperative monitoring, Surgical sponges, Hemorrhage prevention, Therapeutic use of proteins, Sinusitis treatment, Paranasal sinus surgery, Polysaccharides, Thrombin, Comparative studies, Endoscopy, Hemostasis, Health outcome assessment, Surgery, T-test (Statistics), Cutaneous therapeutics, U-statistics, Randomized controlled trials, Treatment effectiveness, Therapeutics |
| Abstract: | Objectives: Purified plant polysaccharide (HemoStase) is a plant-derived hemostatic agent that has not previously been used in sinus surgery. This study was conducted to evaluate the effectiveness of this novel agent in the control of nasal bleeding during endoscopic sinus surgery. The volume of bleeding during endoscopic sinus surgery was hypothesized to not be statistically significantly different between a control group (gelatin-thrombin matrix; FloSeal) and an experimental group (purified plant polysaccharide; HemoStase). Methods: Eighteen patients with a history of chronic rhinosinusitis in whom maximal medical therapy failed who underwent endoscopic sinus surgery were randomized into one of two groups (control FloSeal group or experimental HemoStase group). In the control group, sites in the nose that were actively bleeding during the operation were controlled with FloSeal. In the experimental group, sites in the nose that were actively bleeding during the operation were controlled with HemoStase. The main outcome measure was total operative blood loss. Blood loss was the sum of blood removed by suction during the surgery (recorded in milliliters) and blood on surgical sponges (weighed and converted to milliliters). Statistical analysis was performed with the i-test and the Mann-Whitney U test. Results: The amounts of blood loss (mean ± SEM) were not significantly different between the FloSeal (262 ± 15 mL) and HemoStase (265 ± 33 mL) groups (p = 0.93). Conclusions: The results of this study demonstrate the use of a novel product for the control of intraoperative bleeding during endoscopic sinus surgery. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 65346104 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Comparison of Purified Plant Polysaccharide (HemoStase) Versus Gelatin-Thrombin Matrix (FloSeal) in Controlling Bleeding During Sinus Surgery: A Randomized Controlled Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Beyea%2C+Jason+A%2E%22">Beyea, Jason A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rotenberg%2C+Brian+W%2E%22">Rotenberg, Brian W.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Otology%2C+Rhinology+%26+Laryngology%22">Annals of Otology, Rhinology & Laryngology</searchLink>. Aug2011, Vol. 120 Issue 8, p495-498. 4p. 2 Black and White Photographs, 1 Chart, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Operative+surgery%22">Operative surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Intraoperative+monitoring%22">Intraoperative monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+sponges%22">Surgical sponges</searchLink><br /><searchLink fieldCode="DE" term="%22Hemorrhage+prevention%22">Hemorrhage prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutic+use+of+proteins%22">Therapeutic use of proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Sinusitis+treatment%22">Sinusitis treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Paranasal+sinus+surgery%22">Paranasal sinus surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Polysaccharides%22">Polysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Thrombin%22">Thrombin</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Endoscopy%22">Endoscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Hemostasis%22">Hemostasis</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Surgery%22">Surgery</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Cutaneous+therapeutics%22">Cutaneous therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22U-statistics%22">U-statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objectives: Purified plant polysaccharide (HemoStase) is a plant-derived hemostatic agent that has not previously been used in sinus surgery. This study was conducted to evaluate the effectiveness of this novel agent in the control of nasal bleeding during endoscopic sinus surgery. The volume of bleeding during endoscopic sinus surgery was hypothesized to not be statistically significantly different between a control group (gelatin-thrombin matrix; FloSeal) and an experimental group (purified plant polysaccharide; HemoStase). Methods: Eighteen patients with a history of chronic rhinosinusitis in whom maximal medical therapy failed who underwent endoscopic sinus surgery were randomized into one of two groups (control FloSeal group or experimental HemoStase group). In the control group, sites in the nose that were actively bleeding during the operation were controlled with FloSeal. In the experimental group, sites in the nose that were actively bleeding during the operation were controlled with HemoStase. The main outcome measure was total operative blood loss. Blood loss was the sum of blood removed by suction during the surgery (recorded in milliliters) and blood on surgical sponges (weighed and converted to milliliters). Statistical analysis was performed with the i-test and the Mann-Whitney U test. Results: The amounts of blood loss (mean ± SEM) were not significantly different between the FloSeal (262 ± 15 mL) and HemoStase (265 ± 33 mL) groups (p = 0.93). Conclusions: The results of this study demonstrate the use of a novel product for the control of intraoperative bleeding during endoscopic sinus surgery. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/000348941112000801 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 495 Subjects: – SubjectFull: Operative surgery Type: general – SubjectFull: Intraoperative monitoring Type: general – SubjectFull: Surgical sponges Type: general – SubjectFull: Hemorrhage prevention Type: general – SubjectFull: Therapeutic use of proteins Type: general – SubjectFull: Sinusitis treatment Type: general – SubjectFull: Paranasal sinus surgery Type: general – SubjectFull: Polysaccharides Type: general – SubjectFull: Thrombin Type: general – SubjectFull: Comparative studies Type: general – SubjectFull: Endoscopy Type: general – SubjectFull: Hemostasis Type: general – SubjectFull: Health outcome assessment Type: general – SubjectFull: Surgery Type: general – SubjectFull: T-test (Statistics) Type: general – SubjectFull: Cutaneous therapeutics Type: general – SubjectFull: U-statistics Type: general – SubjectFull: Randomized controlled trials Type: general – SubjectFull: Treatment effectiveness Type: general – SubjectFull: Therapeutics Type: general Titles: – TitleFull: Comparison of Purified Plant Polysaccharide (HemoStase) Versus Gelatin-Thrombin Matrix (FloSeal) in Controlling Bleeding During Sinus Surgery: A Randomized Controlled Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Beyea, Jason A. – PersonEntity: Name: NameFull: Rotenberg, Brian W. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00034894 Numbering: – Type: volume Value: 120 – Type: issue Value: 8 Titles: – TitleFull: Annals of Otology, Rhinology & Laryngology Type: main |
| ResultId | 1 |
