View in EDS

Common limbic and frontal-striatal disturbances in patients with obsessive compulsive disorder, panic disorder and hypochondriasis.

Saved in:
Bibliographic Details
Title: Common limbic and frontal-striatal disturbances in patients with obsessive compulsive disorder, panic disorder and hypochondriasis.
Authors: van den Heuvel, O. A., Mataix-Cols, D., Zwitser, G., Cath, D. C., van der Werf, Y. D., Groenewegen, H. J., van Balkom, A. J. L. M., Veltman, D. J.
Source: Psychological Medicine. Nov2011, Vol. 41 Issue 11, p2399-2410. 12p.
Subjects: Limbic system physiology, Analysis of covariance, Analysis of variance, Comparative studies, Statistical correlation, Frontal lobe, Hypochondria, Interviewing, Magnetic resonance imaging, Obsessive-compulsive disorder, Panic disorders, Research funding, Statistics, T-test (Statistics), Data analysis, Multiple regression analysis, Task performance, Data analysis software, Physiology
Geographic Terms: Netherlands
Abstract: BackgroundDirect comparisons of brain function between obsessive compulsive disorder (OCD) and other anxiety or OCD spectrum disorders are rare. This study aimed to investigate the specificity of altered frontal-striatal and limbic activations during planning in OCD, a prototypical anxiety disorder (panic disorder) and a putative OCD spectrum disorder (hypochondriasis).MethodThe Tower of London task, a ‘frontal-striatal’ task, was used during functional magnetic resonance imaging measurements in 50 unmedicated patients, diagnosed with OCD (n=22), panic disorder (n=14) or hypochondriasis (n=14), and in 22 healthy subjects. Blood oxygen level-dependent (BOLD) signal changes were calculated for contrasts of interest (planning versus baseline and task load effects). Moreover, correlations between BOLD responses and both task performance and state anxiety were analysed.ResultsOverall, patients showed a decreased recruitment of the precuneus, caudate nucleus, globus pallidus and thalamus, compared with healthy controls. There were no statistically significant differences in brain activation between the three patient groups. State anxiety was negatively correlated with dorsal frontal-striatal activation. Task performance was positively correlated with dorsal frontal-striatal recruitment and negatively correlated with limbic and ventral frontal-striatal recruitment. Multiple regression models showed that adequate task performance was best explained by independent contributions from dorsolateral prefrontal cortex (positive correlation) and amygdala (negative correlation), even after controlling for state anxiety.ConclusionsPatients with OCD, panic disorder and hypochondriasis share similar alterations in frontal-striatal brain regions during a planning task, presumably partly related to increased limbic activation. [ABSTRACT FROM PUBLISHER]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 65931311
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Common limbic and frontal-striatal disturbances in patients with obsessive compulsive disorder, panic disorder and hypochondriasis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22van+den+Heuvel%2C+O%2E+A%2E%22">van den Heuvel, O. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Mataix-Cols%2C+D%2E%22">Mataix-Cols, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Zwitser%2C+G%2E%22">Zwitser, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Cath%2C+D%2E+C%2E%22">Cath, D. C.</searchLink><br /><searchLink fieldCode="AR" term="%22van+der+Werf%2C+Y%2E+D%2E%22">van der Werf, Y. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Groenewegen%2C+H%2E+J%2E%22">Groenewegen, H. J.</searchLink><br /><searchLink fieldCode="AR" term="%22van+Balkom%2C+A%2E+J%2E+L%2E+M%2E%22">van Balkom, A. J. L. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Veltman%2C+D%2E+J%2E%22">Veltman, D. J.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Nov2011, Vol. 41 Issue 11, p2399-2410. 12p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Limbic+system+physiology%22">Limbic system physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+covariance%22">Analysis of covariance</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink><br /><searchLink fieldCode="DE" term="%22Frontal+lobe%22">Frontal lobe</searchLink><br /><searchLink fieldCode="DE" term="%22Hypochondria%22">Hypochondria</searchLink><br /><searchLink fieldCode="DE" term="%22Interviewing%22">Interviewing</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Panic+disorders%22">Panic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Task+performance%22">Task performance</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Netherlands%22">Netherlands</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BackgroundDirect comparisons of brain function between obsessive compulsive disorder (OCD) and other anxiety or OCD spectrum disorders are rare. This study aimed to investigate the specificity of altered frontal-striatal and limbic activations during planning in OCD, a prototypical anxiety disorder (panic disorder) and a putative OCD spectrum disorder (hypochondriasis).MethodThe Tower of London task, a ‘frontal-striatal’ task, was used during functional magnetic resonance imaging measurements in 50 unmedicated patients, diagnosed with OCD (n=22), panic disorder (n=14) or hypochondriasis (n=14), and in 22 healthy subjects. Blood oxygen level-dependent (BOLD) signal changes were calculated for contrasts of interest (planning versus baseline and task load effects). Moreover, correlations between BOLD responses and both task performance and state anxiety were analysed.ResultsOverall, patients showed a decreased recruitment of the precuneus, caudate nucleus, globus pallidus and thalamus, compared with healthy controls. There were no statistically significant differences in brain activation between the three patient groups. State anxiety was negatively correlated with dorsal frontal-striatal activation. Task performance was positively correlated with dorsal frontal-striatal recruitment and negatively correlated with limbic and ventral frontal-striatal recruitment. Multiple regression models showed that adequate task performance was best explained by independent contributions from dorsolateral prefrontal cortex (positive correlation) and amygdala (negative correlation), even after controlling for state anxiety.ConclusionsPatients with OCD, panic disorder and hypochondriasis share similar alterations in frontal-striatal brain regions during a planning task, presumably partly related to increased limbic activation. [ABSTRACT FROM PUBLISHER]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=65931311
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1017/S0033291711000535
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 2399
    Subjects:
      – SubjectFull: Limbic system physiology
        Type: general
      – SubjectFull: Analysis of covariance
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Statistical correlation
        Type: general
      – SubjectFull: Frontal lobe
        Type: general
      – SubjectFull: Hypochondria
        Type: general
      – SubjectFull: Interviewing
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Obsessive-compulsive disorder
        Type: general
      – SubjectFull: Panic disorders
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Task performance
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Physiology
        Type: general
      – SubjectFull: Netherlands
        Type: general
    Titles:
      – TitleFull: Common limbic and frontal-striatal disturbances in patients with obsessive compulsive disorder, panic disorder and hypochondriasis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: van den Heuvel, O. A.
      – PersonEntity:
          Name:
            NameFull: Mataix-Cols, D.
      – PersonEntity:
          Name:
            NameFull: Zwitser, G.
      – PersonEntity:
          Name:
            NameFull: Cath, D. C.
      – PersonEntity:
          Name:
            NameFull: van der Werf, Y. D.
      – PersonEntity:
          Name:
            NameFull: Groenewegen, H. J.
      – PersonEntity:
          Name:
            NameFull: van Balkom, A. J. L. M.
      – PersonEntity:
          Name:
            NameFull: Veltman, D. J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2011
              Type: published
              Y: 2011
          Identifiers:
            – Type: issn-print
              Value: 00332917
          Numbering:
            – Type: volume
              Value: 41
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Psychological Medicine
              Type: main
ResultId 1