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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding.

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Title: Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding.
Authors: Scheid, Johannes F. (AUTHOR), Mouquet, Hugo (AUTHOR), Ueberheide, Beatrix (AUTHOR), Diskin, Ron (AUTHOR), Klein, Florian (AUTHOR), Oliveira, Thiago T. K. (AUTHOR), Pietzsch, John (AUTHOR), Fenyo, David (AUTHOR), Abadir, Alexander (AUTHOR), Velinzon, Klara (AUTHOR), Hurley, Arlene (AUTHOR), Myung, Sunnie (AUTHOR), Boulad, Farid (AUTHOR), Poignard, Pascal (AUTHOR), Burton, Dennis R. (AUTHOR), Pereyra, Florencia (AUTHOR), Ho, David D. (AUTHOR), Walker, Bruce D. (AUTHOR), Seaman, Michael S. (AUTHOR), Bjorkman, Pamela J. (AUTHOR)
Source: Science (pre-March 2025). 9/16/2011, Vol. 333 Issue 6049, p1633-1637. 5p.
Subjects: HIV antibodies, Immunoglobulins, HIV, HIV prevention, Binding sites, Biomolecules
Abstract: Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests that vaccines that elicit such antibodies would be protective. Thus far, however, few broadly neutralizing HIV antibodies that occur naturally have been characterized. To determine whether these antibodies are part of a larger group of related molecules, we cloned 576 new HIV antibodies from four unrelated individuals. All four individuals produced expanded clones of potent broadly neutralizing CD4-binding-site antibodies that mimic binding to CD4. Despite extensive hypermutation, the new antibodies shared a consensus sequence of 68 immunoglobulin H (IgH) chain amino acids and arise independently from two related IgH genes. Comparison of the crystal structure of one of the antibodies to the broadly neutralizing antibody VRCOl revealed conservation of the contacts to the HIV spike. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding.
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  Data: <searchLink fieldCode="AR" term="%22Scheid%2C+Johannes+F%2E%22">Scheid, Johannes F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mouquet%2C+Hugo%22">Mouquet, Hugo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ueberheide%2C+Beatrix%22">Ueberheide, Beatrix</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Diskin%2C+Ron%22">Diskin, Ron</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Klein%2C+Florian%22">Klein, Florian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oliveira%2C+Thiago+T%2E+K%2E%22">Oliveira, Thiago T. K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pietzsch%2C+John%22">Pietzsch, John</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fenyo%2C+David%22">Fenyo, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abadir%2C+Alexander%22">Abadir, Alexander</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Velinzon%2C+Klara%22">Velinzon, Klara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hurley%2C+Arlene%22">Hurley, Arlene</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Myung%2C+Sunnie%22">Myung, Sunnie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Boulad%2C+Farid%22">Boulad, Farid</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poignard%2C+Pascal%22">Poignard, Pascal</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burton%2C+Dennis+R%2E%22">Burton, Dennis R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pereyra%2C+Florencia%22">Pereyra, Florencia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ho%2C+David+D%2E%22">Ho, David D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Walker%2C+Bruce+D%2E%22">Walker, Bruce D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seaman%2C+Michael+S%2E%22">Seaman, Michael S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bjorkman%2C+Pamela+J%2E%22">Bjorkman, Pamela J.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 9/16/2011, Vol. 333 Issue 6049, p1633-1637. 5p.
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  Data: <searchLink fieldCode="DE" term="%22HIV+antibodies%22">HIV antibodies</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulins%22">Immunoglobulins</searchLink><br /><searchLink fieldCode="DE" term="%22HIV%22">HIV</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+prevention%22">HIV prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Binding+sites%22">Binding sites</searchLink><br /><searchLink fieldCode="DE" term="%22Biomolecules%22">Biomolecules</searchLink>
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  Label: Abstract
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  Data: Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests that vaccines that elicit such antibodies would be protective. Thus far, however, few broadly neutralizing HIV antibodies that occur naturally have been characterized. To determine whether these antibodies are part of a larger group of related molecules, we cloned 576 new HIV antibodies from four unrelated individuals. All four individuals produced expanded clones of potent broadly neutralizing CD4-binding-site antibodies that mimic binding to CD4. Despite extensive hypermutation, the new antibodies shared a consensus sequence of 68 immunoglobulin H (IgH) chain amino acids and arise independently from two related IgH genes. Comparison of the crystal structure of one of the antibodies to the broadly neutralizing antibody VRCOl revealed conservation of the contacts to the HIV spike. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=66346954
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