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Combined kidney and liver transplantation for familial haemolytic uraemic syndrome.

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Title: Combined kidney and liver transplantation for familial haemolytic uraemic syndrome.
Authors: Remuzzi, Giuseppe, Ruggenenti, Piero, Codazzi, Daniela, Noris, Marina, Caprioli, Jessica, Locatelli, Giuseppe, Gridelli, Bruno
Source: Lancet. 5/11/2002, Vol. 359 Issue 9318, p1671. 2p. 1 Diagram.
Subjects: Hemolytic-uremic syndrome, Acute kidney failure, Kidney transplantation, Liver transplantation
Abstract: Recurrent haemolytic uraemic syndrome (HUS) is a genetic form of thrombotic microangiopathy that is mostly associated with low activity of complement factor H. The disorder usually develops in families, leads to end stage renal disease, and invariably recurs after kidney transplantation. We did a simultaneous kidney and liver transplantation in a 2-year-old child with HUS and a mutation in complement factor H to restore the defective factor H, with no recurrence of the disease. The operation was successful, and at discharge, the child had healthy kidney and liver function, with no sign of haemolysis. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Combined kidney and liver transplantation for familial haemolytic uraemic syndrome.
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  Data: <searchLink fieldCode="AR" term="%22Remuzzi%2C+Giuseppe%22">Remuzzi, Giuseppe</searchLink><br /><searchLink fieldCode="AR" term="%22Ruggenenti%2C+Piero%22">Ruggenenti, Piero</searchLink><br /><searchLink fieldCode="AR" term="%22Codazzi%2C+Daniela%22">Codazzi, Daniela</searchLink><br /><searchLink fieldCode="AR" term="%22Noris%2C+Marina%22">Noris, Marina</searchLink><br /><searchLink fieldCode="AR" term="%22Caprioli%2C+Jessica%22">Caprioli, Jessica</searchLink><br /><searchLink fieldCode="AR" term="%22Locatelli%2C+Giuseppe%22">Locatelli, Giuseppe</searchLink><br /><searchLink fieldCode="AR" term="%22Gridelli%2C+Bruno%22">Gridelli, Bruno</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 5/11/2002, Vol. 359 Issue 9318, p1671. 2p. 1 Diagram.
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  Data: <searchLink fieldCode="DE" term="%22Hemolytic-uremic+syndrome%22">Hemolytic-uremic syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Acute+kidney+failure%22">Acute kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+transplantation%22">Kidney transplantation</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+transplantation%22">Liver transplantation</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Recurrent haemolytic uraemic syndrome (HUS) is a genetic form of thrombotic microangiopathy that is mostly associated with low activity of complement factor H. The disorder usually develops in families, leads to end stage renal disease, and invariably recurs after kidney transplantation. We did a simultaneous kidney and liver transplantation in a 2-year-old child with HUS and a mutation in complement factor H to restore the defective factor H, with no recurrence of the disease. The operation was successful, and at discharge, the child had healthy kidney and liver function, with no sign of haemolysis. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/S0140-6736(02)08560-4
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        Type: general
      – SubjectFull: Acute kidney failure
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              Text: 5/11/2002
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              Y: 2002
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