Intermittent ethanol exposure increases long-lasting behavioral and neurochemical effects of MDMA in adolescent mice.
Saved in:
| Title: | Intermittent ethanol exposure increases long-lasting behavioral and neurochemical effects of MDMA in adolescent mice. |
|---|---|
| Authors: | Rodríguez-Arias, Marta, Maldonado, Concepción, Vidal-Infer, Antonio, Guerri, Consuelo, Aguilar, María, Miñarro, José |
| Source: | Psychopharmacology. Nov2011, Vol. 218 Issue 2, p429-442. 14p. 3 Charts, 4 Graphs. |
| Subjects: | Ecstasy (Drug), Ethanol, Neurochemistry, Laboratory mice, Binge drinking, Amines, Social interaction |
| Abstract: | Rationale: Heavy binge drinking is increasingly frequent among adolescents, while ethanol (EtOH) is often used in combination with 3,4-methylenedioxymethamphetamine (MDMA). Objectives: The long-lasting effects of intermittent exposure to EtOH and MDMA during adolescence on motor activity, anxiety, and social behavior were evaluated in adult mice. The concentration of brain monoamines in the striatum, cortex, and hippocampus was measured following the behavioral test. Methods: Adolescent OF1 mice were exposed to ethanol (1.25 g/kg) on two consecutive days at 48-h intervals over a 14-day period (from PND 29 to 42). A total of eight injections of MDMA (10 or 20 mg/kg) were administered twice daily at 4-h intervals over two consecutive days, and this schedule was repeated 6 days later (PND 33, 34, 41, and 42). Behavioral tests and analysis of brain monoamines took place on PND 64 to 67. Results: Exposure to MDMA during adolescence increased the anxiogenic response in the elevated plus maze, with adult mice spending less time in the open arms of the maze and exhibiting lower concentrations of DA in the striatum. A pattern of ethanol administration modeling binge drinking during adolescence enhanced these effects and undermined the hyperthermic response induced by MDMA. Passive avoidance was affected only when EtOH was administered alone. Conclusions: Juvenile administration of MDMA and alcohol was found to cause a decrease in monoamine levels in adulthood, as well as changes in social interaction behaviors, locomotor activity, increase measures of anxiety in the elevated plus maze (EPM), and decrease step-through latencies in passive avoidance test. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 66714271 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Intermittent ethanol exposure increases long-lasting behavioral and neurochemical effects of MDMA in adolescent mice. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rodríguez-Arias%2C+Marta%22">Rodríguez-Arias, Marta</searchLink><br /><searchLink fieldCode="AR" term="%22Maldonado%2C+Concepción%22">Maldonado, Concepción</searchLink><br /><searchLink fieldCode="AR" term="%22Vidal-Infer%2C+Antonio%22">Vidal-Infer, Antonio</searchLink><br /><searchLink fieldCode="AR" term="%22Guerri%2C+Consuelo%22">Guerri, Consuelo</searchLink><br /><searchLink fieldCode="AR" term="%22Aguilar%2C+María%22">Aguilar, María</searchLink><br /><searchLink fieldCode="AR" term="%22Miñarro%2C+José%22">Miñarro, José</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Nov2011, Vol. 218 Issue 2, p429-442. 14p. 3 Charts, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Ecstasy+%28Drug%29%22">Ecstasy (Drug)</searchLink><br /><searchLink fieldCode="DE" term="%22Ethanol%22">Ethanol</searchLink><br /><searchLink fieldCode="DE" term="%22Neurochemistry%22">Neurochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Binge+drinking%22">Binge drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Amines%22">Amines</searchLink><br /><searchLink fieldCode="DE" term="%22Social+interaction%22">Social interaction</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Heavy binge drinking is increasingly frequent among adolescents, while ethanol (EtOH) is often used in combination with 3,4-methylenedioxymethamphetamine (MDMA). Objectives: The long-lasting effects of intermittent exposure to EtOH and MDMA during adolescence on motor activity, anxiety, and social behavior were evaluated in adult mice. The concentration of brain monoamines in the striatum, cortex, and hippocampus was measured following the behavioral test. Methods: Adolescent OF1 mice were exposed to ethanol (1.25 g/kg) on two consecutive days at 48-h intervals over a 14-day period (from PND 29 to 42). A total of eight injections of MDMA (10 or 20 mg/kg) were administered twice daily at 4-h intervals over two consecutive days, and this schedule was repeated 6 days later (PND 33, 34, 41, and 42). Behavioral tests and analysis of brain monoamines took place on PND 64 to 67. Results: Exposure to MDMA during adolescence increased the anxiogenic response in the elevated plus maze, with adult mice spending less time in the open arms of the maze and exhibiting lower concentrations of DA in the striatum. A pattern of ethanol administration modeling binge drinking during adolescence enhanced these effects and undermined the hyperthermic response induced by MDMA. Passive avoidance was affected only when EtOH was administered alone. Conclusions: Juvenile administration of MDMA and alcohol was found to cause a decrease in monoamine levels in adulthood, as well as changes in social interaction behaviors, locomotor activity, increase measures of anxiety in the elevated plus maze (EPM), and decrease step-through latencies in passive avoidance test. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=66714271 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-011-2329-x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 429 Subjects: – SubjectFull: Ecstasy (Drug) Type: general – SubjectFull: Ethanol Type: general – SubjectFull: Neurochemistry Type: general – SubjectFull: Laboratory mice Type: general – SubjectFull: Binge drinking Type: general – SubjectFull: Amines Type: general – SubjectFull: Social interaction Type: general Titles: – TitleFull: Intermittent ethanol exposure increases long-lasting behavioral and neurochemical effects of MDMA in adolescent mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rodríguez-Arias, Marta – PersonEntity: Name: NameFull: Maldonado, Concepción – PersonEntity: Name: NameFull: Vidal-Infer, Antonio – PersonEntity: Name: NameFull: Guerri, Consuelo – PersonEntity: Name: NameFull: Aguilar, María – PersonEntity: Name: NameFull: Miñarro, José IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 11 Text: Nov2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 218 – Type: issue Value: 2 Titles: – TitleFull: Psychopharmacology Type: main |
| ResultId | 1 |
