A comprehensive review and model of putative prodromal features of bipolar affective disorder.
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| Title: | A comprehensive review and model of putative prodromal features of bipolar affective disorder. |
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| Authors: | Howes, O. D., Lim, S., Theologos, G., Yung, A. R., Goodwin, G. M., McGuire, P. |
| Source: | Psychological Medicine. Aug2011, Vol. 41 Issue 8, p1567-1577. 11p. |
| Subjects: | Age factors in disease, Analysis of variance, Medical information storage & retrieval systems, Psychology information storage & retrieval systems, Bipolar disorder, MEDLINE, Online information services, Systematic reviews, Early medical intervention, Symptoms, Prevention |
| Abstract: | BackgroundIdentifying prodromal features that predate the onset of bipolar disorder (BD) may enable the prevention of BD and aid early intervention. This review addresses two key questions: Is there a bipolar prodrome? And, if there is, what are its characteristic features?MethodA comprehensive search of databases (PubMed, Medline, EMBASE and PsycINFO) supplemented by hand searches was used to identify studies of symptoms preceding the onset of BD.ResultsFifty-nine studies were identified, of which 14 met inclusion criteria. Symptoms can predate the onset of BD by months to years and can be categorized as attenuated forms of BD symptoms, general symptoms common to a range of mental disorders, and personality traits, particularly cyclothymia. Two studies provided sufficient data to enable sensitivity and specificity to be calculated. Specificity of several of the features was high (>90%) but sensitivity was generally low (all <60%). We propose a model based on the findings in the studies reviewed to illustrate the potential trajectory to BD and the points at which it may be possible to intervene.ConclusionsClinical features preceding the onset of BD can be identified. However, conclusions about whether there is a distinct prodrome to BD are restricted by the limitations of current evidence. The high specificity of some features suggests they may be useful in clinical practice. Large-scale longitudinal studies are needed to validate these features and characterize their specificity and sensitivity in independent samples. [ABSTRACT FROM PUBLISHER] |
| Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 66813398 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A comprehensive review and model of putative prodromal features of bipolar affective disorder. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Howes%2C+O%2E+D%2E%22">Howes, O. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Lim%2C+S%2E%22">Lim, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Theologos%2C+G%2E%22">Theologos, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Yung%2C+A%2E+R%2E%22">Yung, A. R.</searchLink><br /><searchLink fieldCode="AR" term="%22Goodwin%2C+G%2E+M%2E%22">Goodwin, G. M.</searchLink><br /><searchLink fieldCode="AR" term="%22McGuire%2C+P%2E%22">McGuire, P.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Aug2011, Vol. 41 Issue 8, p1567-1577. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Age+factors+in+disease%22">Age factors in disease</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+information+storage+%26+retrieval+systems%22">Medical information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+information+storage+%26+retrieval+systems%22">Psychology information storage & retrieval systems</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22Early+medical+intervention%22">Early medical intervention</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Prevention%22">Prevention</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: BackgroundIdentifying prodromal features that predate the onset of bipolar disorder (BD) may enable the prevention of BD and aid early intervention. This review addresses two key questions: Is there a bipolar prodrome? And, if there is, what are its characteristic features?MethodA comprehensive search of databases (PubMed, Medline, EMBASE and PsycINFO) supplemented by hand searches was used to identify studies of symptoms preceding the onset of BD.ResultsFifty-nine studies were identified, of which 14 met inclusion criteria. Symptoms can predate the onset of BD by months to years and can be categorized as attenuated forms of BD symptoms, general symptoms common to a range of mental disorders, and personality traits, particularly cyclothymia. Two studies provided sufficient data to enable sensitivity and specificity to be calculated. Specificity of several of the features was high (>90%) but sensitivity was generally low (all <60%). We propose a model based on the findings in the studies reviewed to illustrate the potential trajectory to BD and the points at which it may be possible to intervene.ConclusionsClinical features preceding the onset of BD can be identified. However, conclusions about whether there is a distinct prodrome to BD are restricted by the limitations of current evidence. The high specificity of some features suggests they may be useful in clinical practice. Large-scale longitudinal studies are needed to validate these features and characterize their specificity and sensitivity in independent samples. [ABSTRACT FROM PUBLISHER] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=66813398 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1017/S0033291710001790 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1567 Subjects: – SubjectFull: Age factors in disease Type: general – SubjectFull: Analysis of variance Type: general – SubjectFull: Medical information storage & retrieval systems Type: general – SubjectFull: Psychology information storage & retrieval systems Type: general – SubjectFull: Bipolar disorder Type: general – SubjectFull: MEDLINE Type: general – SubjectFull: Online information services Type: general – SubjectFull: Systematic reviews Type: general – SubjectFull: Early medical intervention Type: general – SubjectFull: Symptoms Type: general – SubjectFull: Prevention Type: general Titles: – TitleFull: A comprehensive review and model of putative prodromal features of bipolar affective disorder. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Howes, O. D. – PersonEntity: Name: NameFull: Lim, S. – PersonEntity: Name: NameFull: Theologos, G. – PersonEntity: Name: NameFull: Yung, A. R. – PersonEntity: Name: NameFull: Goodwin, G. M. – PersonEntity: Name: NameFull: McGuire, P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2011 Type: published Y: 2011 Identifiers: – Type: issn-print Value: 00332917 Numbering: – Type: volume Value: 41 – Type: issue Value: 8 Titles: – TitleFull: Psychological Medicine Type: main |
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