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Agouti-related protein in patients with acute and weight-restored anorexia nervosa.

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Title: Agouti-related protein in patients with acute and weight-restored anorexia nervosa.
Authors: Merle, J. V., Haas, V., Burghardt, R., Döhler, N., Schneider, N., Lehmkuhl, U., Ehrlich, S.
Source: Psychological Medicine. Oct2011, Vol. 41 Issue 10, p2183-2192. 10p.
Subjects: Analysis of variance, Anorexia nervosa, Appetite, Enzyme-linked immunosorbent assay, Growth factors, Interviewing, Research methodology, Classification of mental disorders, Psychological tests, Pathological psychology, Research funding, Statistical hypothesis testing, Statistics, U-statistics, Weight gain, Leptin, Data analysis, Symptoms, Case-control method, Data analysis software
Abstract: BackgroundAn imbalance in appetite-regulating neuropeptides of the central nervous system has been associated with anorexia nervosa (AN), but the mechanisms of action are poorly understood. Agouti-related protein (AGRP), an orexigenic mediator of the hypothalamus, increases food intake and decreases energy expenditure in times of negative energy balance. The aim of the present study was to investigate AGRP in acute and fully weight-restored patients with AN, as well as during weight gain.MethodPlasma AGRP and leptin levels were assessed using an enzyme-linked immunosorbent assay kit in a total of 175 female participants, including 75 patients with acute AN, 37 weight-restored AN patients and 63 healthy controls. Of the patients with acute AN, 33 were reassessed after partial weight gain.ResultsIn weight-restored AN patients plasma AGRP levels were similar to those in healthy controls, whereas in patients with acute AN, AGRP was elevated. AGRP was inversely correlated with indicators of undernutrition such as body mass index and plasma leptin. In addition, AGRP levels normalized during weight gain of longitudinally assessed AN patients.ConclusionsOur results underline the significance of undernutrition and hypoleptinemia for the interpretation of peripheral AGRP concentrations. This provides support for the hypothesis that abnormal AGRP plasma levels in AN patients reflect undernutrition, rather than disease-specific traits. [ABSTRACT FROM PUBLISHER]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Agouti-related protein in patients with acute and weight-restored anorexia nervosa.
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  Data: <searchLink fieldCode="AR" term="%22Merle%2C+J%2E+V%2E%22">Merle, J. V.</searchLink><br /><searchLink fieldCode="AR" term="%22Haas%2C+V%2E%22">Haas, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Burghardt%2C+R%2E%22">Burghardt, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Döhler%2C+N%2E%22">Döhler, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Schneider%2C+N%2E%22">Schneider, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Lehmkuhl%2C+U%2E%22">Lehmkuhl, U.</searchLink><br /><searchLink fieldCode="AR" term="%22Ehrlich%2C+S%2E%22">Ehrlich, S.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Oct2011, Vol. 41 Issue 10, p2183-2192. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Anorexia+nervosa%22">Anorexia nervosa</searchLink><br /><searchLink fieldCode="DE" term="%22Appetite%22">Appetite</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme-linked+immunosorbent+assay%22">Enzyme-linked immunosorbent assay</searchLink><br /><searchLink fieldCode="DE" term="%22Growth+factors%22">Growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Interviewing%22">Interviewing</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Classification+of+mental+disorders%22">Classification of mental disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+tests%22">Psychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+hypothesis+testing%22">Statistical hypothesis testing</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22U-statistics%22">U-statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Weight+gain%22">Weight gain</searchLink><br /><searchLink fieldCode="DE" term="%22Leptin%22">Leptin</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink>
– Name: Abstract
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  Data: BackgroundAn imbalance in appetite-regulating neuropeptides of the central nervous system has been associated with anorexia nervosa (AN), but the mechanisms of action are poorly understood. Agouti-related protein (AGRP), an orexigenic mediator of the hypothalamus, increases food intake and decreases energy expenditure in times of negative energy balance. The aim of the present study was to investigate AGRP in acute and fully weight-restored patients with AN, as well as during weight gain.MethodPlasma AGRP and leptin levels were assessed using an enzyme-linked immunosorbent assay kit in a total of 175 female participants, including 75 patients with acute AN, 37 weight-restored AN patients and 63 healthy controls. Of the patients with acute AN, 33 were reassessed after partial weight gain.ResultsIn weight-restored AN patients plasma AGRP levels were similar to those in healthy controls, whereas in patients with acute AN, AGRP was elevated. AGRP was inversely correlated with indicators of undernutrition such as body mass index and plasma leptin. In addition, AGRP levels normalized during weight gain of longitudinally assessed AN patients.ConclusionsOur results underline the significance of undernutrition and hypoleptinemia for the interpretation of peripheral AGRP concentrations. This provides support for the hypothesis that abnormal AGRP plasma levels in AN patients reflect undernutrition, rather than disease-specific traits. [ABSTRACT FROM PUBLISHER]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1017/S0033291711000365
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      – Code: eng
        Text: English
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        PageCount: 10
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      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Anorexia nervosa
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      – SubjectFull: Appetite
        Type: general
      – SubjectFull: Enzyme-linked immunosorbent assay
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      – SubjectFull: Growth factors
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      – SubjectFull: Research methodology
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      – SubjectFull: Classification of mental disorders
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      – SubjectFull: Weight gain
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      – SubjectFull: Leptin
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      – SubjectFull: Data analysis software
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              Text: Oct2011
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