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PI3K? is required for NMDA receptor-dependent long-term depression and behavioral flexibility.

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Title: PI3K? is required for NMDA receptor-dependent long-term depression and behavioral flexibility.
Authors: Kim, Jae-Ick, Lee, Hye-Ryeon, Sim, Su-eon, Baek, Jinhee, Yu, Nam-Kyung, Choi, Jun-Hyeok, Ko, Hyoung-Gon, Lee, Yong-Seok, Park, Soo-Won, Kwak, Chuljung, Ahn, Sung-Ji, Choi, So Yoen, Kim, Hyun, Kim, Kyoung-Han, Backx, Peter H, Bradley, Clarrisa A, Kim, Eunjoon, Jang, Deok-Jin, Lee, Kyungmin, Kim, Sang Jeong
Source: Nature Neuroscience. Nov2011, Vol. 14 Issue 11, p1447-1454. 8p. 7 Graphs.
Subjects: Phosphoinositides, Neuroplasticity, Synapses, Methyl aspartate, Cognitive ability, Brain
Abstract: Phosphatidylinositol 3-kinase (PI3K) has been implicated in synaptic plasticity and other neural functions in the brain. However, the role of individual PI3K isoforms in the brain is unclear. We investigated the role of PI3K? in hippocampal-dependent synaptic plasticity and cognitive functions. We found that PI3K? has a crucial and specific role in NMDA receptor (NMDAR)-mediated synaptic plasticity at mouse Schaffer collateral-commissural synapses. Both genetic deletion and pharmacological inhibition of PI3K? disrupted NMDAR long-term depression (LTD) while leaving other forms of synaptic plasticity intact. Accompanying this physiological deficit, the impairment of NMDAR LTD by PI3K? blockade was specifically correlated with deficits in behavioral flexibility. These findings suggest that a specific PI3K isoform, PI3K?, is critical for NMDAR LTD and some forms of cognitive function. Thus, individual isoforms of PI3Ks may have distinct roles in different types of synaptic plasticity and may therefore influence various kinds of behavior. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: PI3K? is required for NMDA receptor-dependent long-term depression and behavioral flexibility.
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  Data: <searchLink fieldCode="AR" term="%22Kim%2C+Jae-Ick%22">Kim, Jae-Ick</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Hye-Ryeon%22">Lee, Hye-Ryeon</searchLink><br /><searchLink fieldCode="AR" term="%22Sim%2C+Su-eon%22">Sim, Su-eon</searchLink><br /><searchLink fieldCode="AR" term="%22Baek%2C+Jinhee%22">Baek, Jinhee</searchLink><br /><searchLink fieldCode="AR" term="%22Yu%2C+Nam-Kyung%22">Yu, Nam-Kyung</searchLink><br /><searchLink fieldCode="AR" term="%22Choi%2C+Jun-Hyeok%22">Choi, Jun-Hyeok</searchLink><br /><searchLink fieldCode="AR" term="%22Ko%2C+Hyoung-Gon%22">Ko, Hyoung-Gon</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Yong-Seok%22">Lee, Yong-Seok</searchLink><br /><searchLink fieldCode="AR" term="%22Park%2C+Soo-Won%22">Park, Soo-Won</searchLink><br /><searchLink fieldCode="AR" term="%22Kwak%2C+Chuljung%22">Kwak, Chuljung</searchLink><br /><searchLink fieldCode="AR" term="%22Ahn%2C+Sung-Ji%22">Ahn, Sung-Ji</searchLink><br /><searchLink fieldCode="AR" term="%22Choi%2C+So+Yoen%22">Choi, So Yoen</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Hyun%22">Kim, Hyun</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Kyoung-Han%22">Kim, Kyoung-Han</searchLink><br /><searchLink fieldCode="AR" term="%22Backx%2C+Peter+H%22">Backx, Peter H</searchLink><br /><searchLink fieldCode="AR" term="%22Bradley%2C+Clarrisa+A%22">Bradley, Clarrisa A</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Eunjoon%22">Kim, Eunjoon</searchLink><br /><searchLink fieldCode="AR" term="%22Jang%2C+Deok-Jin%22">Jang, Deok-Jin</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Kyungmin%22">Lee, Kyungmin</searchLink><br /><searchLink fieldCode="AR" term="%22Kim%2C+Sang+Jeong%22">Kim, Sang Jeong</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Nov2011, Vol. 14 Issue 11, p1447-1454. 8p. 7 Graphs.
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  Data: Phosphatidylinositol 3-kinase (PI3K) has been implicated in synaptic plasticity and other neural functions in the brain. However, the role of individual PI3K isoforms in the brain is unclear. We investigated the role of PI3K? in hippocampal-dependent synaptic plasticity and cognitive functions. We found that PI3K? has a crucial and specific role in NMDA receptor (NMDAR)-mediated synaptic plasticity at mouse Schaffer collateral-commissural synapses. Both genetic deletion and pharmacological inhibition of PI3K? disrupted NMDAR long-term depression (LTD) while leaving other forms of synaptic plasticity intact. Accompanying this physiological deficit, the impairment of NMDAR LTD by PI3K? blockade was specifically correlated with deficits in behavioral flexibility. These findings suggest that a specific PI3K isoform, PI3K?, is critical for NMDAR LTD and some forms of cognitive function. Thus, individual isoforms of PI3Ks may have distinct roles in different types of synaptic plasticity and may therefore influence various kinds of behavior. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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